Tissue Distribution of Human Monoamine Oxidase A and B mRNA

Journal of Neurochemistry - Tập 55 Số 4 - Trang 1166-1169 - 1990
Joseph Grimsby1, Nancy C. Lan2, Rachael L. Neve3, Kevin Chen2, Jean C. Shih2
1Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
2Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles
3Department of Psychobiology, University of California, Irvine, California, U.S.A.

Tóm tắt

Abstract: Monoamine oxidase (MAO) A and B play important roles in the metabolism of biogenic amines. Northern analysis using 32P‐labeled subfragments of human liver MAO A and B cDNA clones detected a 5‐ and a 3‐kb transcript, respectively, in most human tissues examined. However, fetal heart and thymus express minute amounts of MAO A transcript, whereas fetal brain, muscle, thymus, spleen, meninges, and placenta express minute amounts of MAO B transcript. Small intestine and placenta express, in addition to the MAO A 5‐kb transcript, a 2‐kb transcript, which may arise from an alternative polyadenylation site. MAO A and B transcripts are expressed in similar regions of adult human brain. The highest concentrations of these transcripts were located in frontal cortex and locus coeruleus. This study demonstrates the tissue‐specific distribution of the MAO genes and will provide insight into the physiological functions of MAO A and B.

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Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Journal of Neurochemistry

Tập 55 Số 4

1166-1169

Thông tin tác giả