Journal of Nanobiotechnology

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An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy
Journal of Nanobiotechnology - Tập 21 - Trang 1-16 - 2023
Yanzhen Yu, Hangfei Jin, Linbin Li, Xin Zhang, Chunfang Zheng, Xi Gao, Yunxi Yang, Bingwei Sun
Chronic diabetic wounds are primarily caused by infection, inflammation, and angiogenesis-related disorders. An ideal approach for treating chronic diabetic wounds is by combining anti-infection strategies, immune microenvironment regulation, and angiogenesis promotion. Vascular endothelial growth factor (VEGF) can promote the proliferation and migration of vascular endothelial cells, thereby prom...... hiện toàn bộ
Chondroitin sulfate-AuNRs electroactive scaffolds for on-demand release of biofactors
Journal of Nanobiotechnology - Tập 20 - Trang 1-9 - 2022
Maayan Malki, Assaf Shapira, Tal Dvir
Controlled release systems are often integrated into polymeric scaffolds to supply essential biofactors to trigger physiological processes in engineered tissues. Here, we report the modification of chondroitin sulfate (CS) electroactive polymer with gold nanorods (AuNRs) to create hybrid macroporous scaffolds for enhanced on-demand release of growth factors and cytokines. The mechanical properties...... hiện toàn bộ
Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury
Journal of Nanobiotechnology -
Yuanpeng Nie, Liying Wang, Shengbo Liu, Chenyang Dai, Tianjiao Cui, Yan Liu, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng
AbstractAcute kidney injury (AKI) is a common kidney disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low kidney targeting and undesired side effects, the existing antioxidant and anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential to develop effective nanodrugs with high renal ta...... hiện toàn bộ
Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis
Journal of Nanobiotechnology - Tập 19 - Trang 1-13 - 2021
Yan Zhang, Yifei Yin, Wei Zhang, Hongyan Li, Taixia Wang, Haohao Yin, Liping Sun, Chunxia Su, Kun Zhang, Huixiong Xu
As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation closely correlate with the evolution of atherosclerotic plaques, and they directly participate in all stages of atherosclerosis. Regarding this, anti-oxidation or anti-inflammation drugs were d...... hiện toàn bộ
N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging
Journal of Nanobiotechnology - Tập 6 - Trang 1-9 - 2008
Shanta R Bhattarai, Remant B Kc, Sun Y Kim, Manju Sharma, Myung S Khil, Pyoung H Hwang, Gyung H Chung, Hak Y Kim
This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and satu...... hiện toàn bộ
Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment
Journal of Nanobiotechnology - - 2022
Ying Liu, Wei Zhao, Yanli Wang, Haiyan Wang, Shanglong Liu
AbstractPancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate an exchange of information both within the TME and to...... hiện toàn bộ
Antimicrobial effectiveness of silver nanoparticles co-stabilized by the bioactive copolymer pluronic F68
Journal of Nanobiotechnology - Tập 10 - Trang 1-6 - 2012
Carolina Alves dos Santos, Angela Faustino Jozala, Adalberto Pessoa Jr, Marcelo Martins Seckler
Silver nanoparticles (AgNps) have attracted much interest in biomedical engineering, since they have excellent antimicrobial properties. Therefore, AgNps have often been considered for incorporation into medical products for skin pathologies to reduce the risk of contamination. This study aims at evaluating the antimicrobial effectiveness of AgNps stabilized by pluronic™ F68 associated with other ...... hiện toàn bộ
A pump-free and high-throughput microfluidic chip for highly sensitive SERS assay of gastric cancer-related circulating tumor DNA via a cascade signal amplification strategy
Journal of Nanobiotechnology - Tập 20 - Trang 1-13 - 2022
Xiaowei Cao, Shengjie Ge, Weiwei Hua, Xinyu Zhou, Wenbo Lu, Yingyan Gu, Zhiyue Li, Yayun Qian
Circulating tumour DNA (ctDNA) has emerged as an ideal biomarker for the early diagnosis and prognosis of gastric cancer (GC). In this work, a pump-free, high-throughput microfluidic chip coupled with catalytic hairpin assembly (CHA) and hybridization chain reaction (HCR) as the signal cascade amplification strategy (CHA–HCR) was developed for surface-enhanced Raman scattering (SERS) assays of PIK...... hiện toàn bộ
Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions
Journal of Nanobiotechnology - Tập 20 - Trang 1-17 - 2022
Xiaohui Jia, Zhihua Yuan, Yuqin Yang, Xuemei Huang, Nana Han, Xiaojing Liu, Xiaoyu Lin, Tao Ma, Bing Xu, Penglong Wang, Haimin Lei
Oral administration of insulin (INS) could be absorbed into systemic circulation only if the carrier protected it from the hostile gastrointestinal conditions. However, traditional macromolecular carriers have not totally overcome challenges in addressing these biological barriers. In this study, inspired by small molecule natural products (SMNPs), we demonstrate the multi-functional self-assembly...... hiện toàn bộ
Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy
Journal of Nanobiotechnology - Tập 19 - Trang 1-35 - 2021
Wei Cao, Mengyao Jin, Kang Yang, Bo Chen, Maoming Xiong, Xiang Li, Guodong Cao
Chemodynamic therapy (CDT) catalyzed by transition metal and starvation therapy catalyzed by intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of metal ions and insufficient endogenous hydrogen peroxide (H2O2). Also, single starvation therapy shows limited ability on resisting tumors. The “...... hiện toàn bộ
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