Journal of Nanobiotechnology

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An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy
Journal of Nanobiotechnology - Tập 21 - Trang 1-16 - 2023
Yanzhen Yu, Hangfei Jin, Linbin Li, Xin Zhang, Chunfang Zheng, Xi Gao, Yunxi Yang, Bingwei Sun
Chronic diabetic wounds are primarily caused by infection, inflammation, and angiogenesis-related disorders. An ideal approach for treating chronic diabetic wounds is by combining anti-infection strategies, immune microenvironment regulation, and angiogenesis promotion. Vascular endothelial growth factor (VEGF) can promote the proliferation and migration of vascular endothelial cells, thereby prom...... hiện toàn bộ
Chondroitin sulfate-AuNRs electroactive scaffolds for on-demand release of biofactors
Journal of Nanobiotechnology - Tập 20 - Trang 1-9 - 2022
Maayan Malki, Assaf Shapira, Tal Dvir
Controlled release systems are often integrated into polymeric scaffolds to supply essential biofactors to trigger physiological processes in engineered tissues. Here, we report the modification of chondroitin sulfate (CS) electroactive polymer with gold nanorods (AuNRs) to create hybrid macroporous scaffolds for enhanced on-demand release of growth factors and cytokines. The mechanical properties...... hiện toàn bộ
Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury
Journal of Nanobiotechnology -
Yuanpeng Nie, Liying Wang, Shengbo Liu, Chenyang Dai, Tianjiao Cui, Yan Liu, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng
AbstractAcute kidney injury (AKI) is a common kidney disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low kidney targeting and undesired side effects, the existing antioxidant and anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential to develop effective nanodrugs with high renal ta...... hiện toàn bộ
Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis
Journal of Nanobiotechnology - Tập 19 - Trang 1-13 - 2021
Yan Zhang, Yifei Yin, Wei Zhang, Hongyan Li, Taixia Wang, Haohao Yin, Liping Sun, Chunxia Su, Kun Zhang, Huixiong Xu
As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation closely correlate with the evolution of atherosclerotic plaques, and they directly participate in all stages of atherosclerosis. Regarding this, anti-oxidation or anti-inflammation drugs were d...... hiện toàn bộ
Antimicrobial effectiveness of silver nanoparticles co-stabilized by the bioactive copolymer pluronic F68
Journal of Nanobiotechnology - Tập 10 - Trang 1-6 - 2012
Carolina Alves dos Santos, Angela Faustino Jozala, Adalberto Pessoa Jr, Marcelo Martins Seckler
Silver nanoparticles (AgNps) have attracted much interest in biomedical engineering, since they have excellent antimicrobial properties. Therefore, AgNps have often been considered for incorporation into medical products for skin pathologies to reduce the risk of contamination. This study aims at evaluating the antimicrobial effectiveness of AgNps stabilized by pluronic™ F68 associated with other ...... hiện toàn bộ
Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions
Journal of Nanobiotechnology - Tập 20 - Trang 1-17 - 2022
Xiaohui Jia, Zhihua Yuan, Yuqin Yang, Xuemei Huang, Nana Han, Xiaojing Liu, Xiaoyu Lin, Tao Ma, Bing Xu, Penglong Wang, Haimin Lei
Oral administration of insulin (INS) could be absorbed into systemic circulation only if the carrier protected it from the hostile gastrointestinal conditions. However, traditional macromolecular carriers have not totally overcome challenges in addressing these biological barriers. In this study, inspired by small molecule natural products (SMNPs), we demonstrate the multi-functional self-assembly...... hiện toàn bộ
A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer
Journal of Nanobiotechnology - Tập 21 - Trang 1-13 - 2023
Miaomiao Yuan, Tong Chen, Lu Jin, Peng Zhang, Luoyijun Xie, Shuyi Zhou, Lianfeng Fan, Li Wang, Cai Zhang, Ning Tang, LiHao Guo, Chengmei Xie, Yanhong Duo, Ling Li, Leilei Shi
Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate adverse events. Poly-ADP-Ribose Polymerase (PARP) participates in the maintenance of genome stability and the repair of DNA damage, thus playing a critical role in chemotherapy resistance. In t...... hiện toàn bộ
A simple immunoassay for extracellular vesicle liquid biopsy in microliters of non-processed plasma
Journal of Nanobiotechnology - Tập 20 - Trang 1-19 - 2022
Carmen Campos-Silva, Yaiza Cáceres-Martell, Estela Sánchez-Herrero, Amaia Sandúa, Alexandra Beneitez-Martínez, Álvaro González, Mariano Provencio, Atocha Romero, Ricardo Jara-Acevedo, María Yáñez-Mó, Mar Valés‐Gómez
Extracellular vesicles (EVs), released by most cell types, provide an excellent source of biomarkers in biological fluids. However, in order to perform validation studies and screenings of patient samples, it is still necessary to develop general techniques permitting rapid handling of small amounts of biological samples from large numbers of donors. Here we describe a method that, using just a fe...... hiện toàn bộ
Binary-blend fibber-based capture assay of circulating tumor cells for clinical diagnosis of colorectal cancer
Journal of Nanobiotechnology - Tập 16 - Trang 1-16 - 2018
Ai-Wei Lee, Fu-Xiang Lin, Po-Li Wei, Guo Jian-Wei, Jem-Kun Chen
In addition to conventional approaches, detecting and characterizing CTCs in patient blood allows for early diagnosis of cancer metastasis. We blended poly(ethylene oxide) (PEO) into nylon-6 through electrospinning to generate a fibrous matbased circulating tumour cells (CTCs) assay. The contents of nylon-6 and PEO in the electrospun blend fibrous mats (EBFMs) were optimized to facilitate high cel...... hiện toàn bộ
Novel pegylated silver coated carbon nanotubes kill Salmonella but they are non-toxic to eukaryotic cells
Journal of Nanobiotechnology - - 2015
Atul A. Chaudhari, Shanese L. Jasper, Ejovwoke F. Dosunmu, Michael E. Miller, Robert D. Arnold, Shree R. Singh, Shreekumar R. Pillai
Tổng số: 1,776   
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