Journal of Nanobiotechnology

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An injectable, activated neutrophil-derived exosome mimetics/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy
Journal of Nanobiotechnology - Tập 21 - Trang 1-16 - 2023
Yanzhen Yu, Hangfei Jin, Linbin Li, Xin Zhang, Chunfang Zheng, Xi Gao, Yunxi Yang, Bingwei Sun
Chronic diabetic wounds are primarily caused by infection, inflammation, and angiogenesis-related disorders. An ideal approach for treating chronic diabetic wounds is by combining anti-infection strategies, immune microenvironment regulation, and angiogenesis promotion. Vascular endothelial growth factor (VEGF) can promote the proliferation and migration of vascular endothelial cells, thereby prom... hiện toàn bộ
Chondroitin sulfate-AuNRs electroactive scaffolds for on-demand release of biofactors
Journal of Nanobiotechnology - Tập 20 - Trang 1-9 - 2022
Maayan Malki, Assaf Shapira, Tal Dvir
Controlled release systems are often integrated into polymeric scaffolds to supply essential biofactors to trigger physiological processes in engineered tissues. Here, we report the modification of chondroitin sulfate (CS) electroactive polymer with gold nanorods (AuNRs) to create hybrid macroporous scaffolds for enhanced on-demand release of growth factors and cytokines. The mechanical properties... hiện toàn bộ
Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury
Journal of Nanobiotechnology -
Yuanpeng Nie, Liying Wang, Shengbo Liu, Chenyang Dai, Tianjiao Cui, Yan Liu, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng
AbstractAcute kidney injury (AKI) is a common kidney disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low kidney targeting and undesired side effects, the existing antioxidant and anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential to develop effective nanodrugs with high renal targeting and biocompatibility for ... hiện toàn bộ
Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis
Journal of Nanobiotechnology - Tập 19 - Trang 1-13 - 2021
Yan Zhang, Yifei Yin, Wei Zhang, Hongyan Li, Taixia Wang, Haohao Yin, Liping Sun, Chunxia Su, Kun Zhang, Huixiong Xu
As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation closely correlate with the evolution of atherosclerotic plaques, and they directly participate in all stages of atherosclerosis. Regarding this, anti-oxidation or anti-inflammation drugs were d... hiện toàn bộ
N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging
Journal of Nanobiotechnology - Tập 6 - Trang 1-9 - 2008
Shanta R Bhattarai, Remant B Kc, Sun Y Kim, Manju Sharma, Myung S Khil, Pyoung H Hwang, Gyung H Chung, Hak Y Kim
This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and satu... hiện toàn bộ
Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement
Journal of Nanobiotechnology - - 2024
Huan Shen, Li Pan, Keke Ning, Yuefei Fang, Bahtiyor Muhitdinov, Ergang Liu, Yongzhuo Huang
Acute lung injury (ALI) is a fatal respiratory disease caused by overreactive immune reactions (e.g., SARS-CoV-2 infection), with a high mortality rate. Its treatment is often compromised by inefficient drug delivery barriers and insufficient potency of the currently used drugs. Therefore, developing a highly effective lung-targeted drug delivery strategy is a pressing clinical need. In this study... hiện toàn bộ
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p
Journal of Nanobiotechnology - Tập 22 - Trang 1-19 - 2024
Dongdong Lu, Yisi Liu, Luyuan Kang, Xiangyu Zhang, Jie Hu, Hao Ye, Bingxu Huang, Yujun Wu, Jinbiao Zhao, Zhaolai Dai, Junjun Wang, Dandan Han
The intestinal development in early life is profoundly influenced by multiple biological components of breast milk, in which milk-derived extracellular vesicles (mEVs) contain a large amount of vertically transmitted signal from the mother. However, little is known about how maternal fiber-rich diet regulates offspring intestinal development by influencing the mEVs. In this study, we found that ma... hiện toàn bộ
Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment
Journal of Nanobiotechnology - Tập 21 - Trang 1-15 - 2023
Yipeng Zhang, Liying Wang, Zi-Dan Wang, Quan Zhou, Xuefei Zhou, Tianhua Zhou, Yi-Xin Guan, Xiangrui Liu
Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation and dysregulation localized within the lining of the large bowel. However, the success of current available approaches used for colon-targeted therapy is limited. Budesonide (BUD) is a corti... hiện toàn bộ
Dancing in local space: rolling hoop orbital amplification combined with local cascade nanozyme catalytic system to achieve ultra-sensitive detection of exosomal miRNA
Journal of Nanobiotechnology - Tập 20 Số 1 - Trang 1-14 - 2022
Gao, Xin, Wu, Haiping, Li, Yujian, Zhang, Lu, Song, Mingxuan, Fu, Xuhuai, Chen, Rui, Ding, Shijia, Zeng, Jiawei, Li, Jia, Liu, Ping
The exosomal miRNA (exo-miRNA) derived from tumor cells contains rich biological information that can effectively aid in the early diagnosis of disease. However, the extremely low abundance imposes stringent requirements for accurate detection techniques. In this study, a novel, protease-free DNA amplification strategy, known as “Rolling Hoop Orbital Amplification” (RHOA), was initially developed ... hiện toàn bộ
Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment
Journal of Nanobiotechnology - - 2022
Ying Liu, Wei Zhao, Yanli Wang, Haiyan Wang, Shanglong Liu
AbstractPancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate an exchange of information both within the TME and to distant organs. EVs have also be... hiện toàn bộ
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