EXPRESSION OF THE RAT AMYLIN (IAPP / DAP) GENE.Journal of Molecular Endocrinology - Tập 3 Số 1 - Trang R1-R4 - 1989
G. Ferrier, A.M. Pierson, Philip Jones, S. R. Bloom, Samia I. Girgis, S. Legon
ABSTRACT
We have used the polymerase chain reaction with mixed sequence primers to generate a probe for rat amylin and have used this to detect expression in various rat tissues. Amylin mRNA is found in greatest concentrations in the pancreas where a single mRNA species can be detected giving a hybridisation signal intensity approximately 10% that of insulin mRNA. ...... hiện toàn bộ
Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesinJournal of Molecular Endocrinology - Tập 18 Số 1 - Trang 77-85 - 1997
SM Luoh, Francesco Di Marco, Nathan W. Levin, Mark Armanini, M-H Xie, Carl P. Nelson, G L Bennett, Mark Mon‐Williams, Steven A. Spencer, Austin Gurney, Frédéric J. de Sauvage
ABSTRACT
Leptin, the product of the ob gene, is a hormone secreted by fat cells which is primarily involved in the regulation of body weight. We have generated a leptin immunoadhesin (leptin-IgG) which was more potent than leptin alone at reducing body weight and food intake when injected into ob/ob mice. This m...... hiện toàn bộ
Functions of the DRY motif and intracellular loop 2 of human melanocortin 3 receptorJournal of Molecular Endocrinology - Tập 53 Số 3 - Trang 319-330 - 2014
Hui Huang, Ya‐Xiong Tao
The melanocortin 3 receptor (MC3R) regulates several physiological functions, including feed efficiency, nutrient partitioning, fasting response, natriuresis, and immune reactions. Naturally occurring mutations in theMC3Rgene have been shown to be associated with increased adiposity and lung diseases such as tuberculosis and cystic fibrosis. The DRY motif at the ...... hiện toàn bộ
Functions of DPLIY motif and helix 8 of human melanocortin-3 receptorJournal of Molecular Endocrinology - Tập 55 Số 2 - Trang 107-117 - 2015
Jing Wang, Zhili Huang, Ya‐Xiong Tao
The melanocortin-3 receptor (MC3R) is a member of the family A G protein-coupled receptors (GPCRs). The MC3R remains the most enigmatic of the melanocortin receptors with regard to its physiological functions, especially its role in energy homeostasis. The N/DPxxY motif and the eighth helix (helix 8) in the carboxyl terminus of GPCRs have been identified to be important for receptor expres...... hiện toàn bộ
Transcriptional coregulator RIP140: an essential regulator of physiologyJournal of Molecular Endocrinology - Tập 58 Số 3 - Trang R147-R158 - 2017
Jaya Nautiyal
Transcriptional coregulators drive gene regulatory decisions in the transcriptional space. Although transcription factors including all nuclear receptors provide a docking platform for coregulators to bind, these proteins bring enzymatic capabilities to the gene regulatory sites. RIP140 is a transcriptional coregulator essential for several physiological processes, and aberrations in its f...... hiện toàn bộ
Multiple forms of parathyroid hormone-like proteins in a human tumourJournal of Molecular Endocrinology - Tập 2 Số 1 - Trang 11-20 - 1989
Hilary M. Docherty, David A. Heath
ABSTRACT
The extensive chromatographic characterization of four parathyroid hormone (PTH)-like proteins in a human bronchial carcinoid tumour associated with humoral hypercalcaemia and severe osteitis fibrosa is described. PTH-like bioactivity was detected in acetic acid extracts of the tumour using an in-vitro osteosarcoma cell bioassay. The active tumour proteins...... hiện toàn bộ
Defining lipid mediators of insulin resistance: controversies and challengesJournal of Molecular Endocrinology - Tập 62 Số 1 - Trang R65-R82 - 2019
Louise Metcalfe, Greg C. Smith, Nigel Turner
Essential elements of all cells – lipids – play important roles in energy production, signalling and as structural components. Despite these critical functions, excessive availability and intracellular accumulation of lipid is now recognised as a major factor contributing to many human diseases, including obesity and diabetes. In the context of these metabolic disorders, ectopic deposition...... hiện toàn bộ