Journal of Molecular Endocrinology

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Cytochrome P-450 17α-hydroxylase protein and mRNA in the testis of the testicular feminized (Tfm) mouse
Journal of Molecular Endocrinology - Tập 11 Số 1 - Trang 77-82 - 1993
P. O'Shaughnessy, Lyn I. Murphy
ABSTRACT The testicular feminized (Tfm) mouse lacks functional androgen receptors and develops with a female external phenotype and internal testes. The testes of these animals contain normal, or close to normal, numbers of Leydig cells but secrete very low amounts of androgen due to a lack of 17α-hydroxylase activity. To determine whether this loss of activity is due to a lack of enzyme synthesis... hiện toàn bộ
Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression
Journal of Molecular Endocrinology - Tập 6 Số 2 - Trang 179-188 - 1991
M C Slootweg, Rolf P. de Groot, M. P. M. Herrmann‐Erlee, I. Koornneef, Wiebe Kruijer, Y. M. Kramer
ABSTRACT Although the structure of several members of the GH receptor family has been defined, signal transduction following GH binding to its receptor has not been elucidated. Mouse osteoblasts were used to study the effect of GH on immediate early gene expression and, subsequently, the cellular signal(s) mediating this expression were analysed. GH rapidly and transiently induced the expression o... hiện toàn bộ
Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells
Journal of Molecular Endocrinology - Tập 19 Số 3 - Trang 347-350 - 1997
Kaltoom Al‐Sakkaf, P R Dobson, B. L. Brown
Our previous studies indicated that PI3-kinase is involved in prolactin (PRL) signalling. We have now examined the involvement of the src tyrosine kinase, fyn, in PRL-induced the activation of PI3-kinase in the rat lymphoma cell line, Nb2. Cells were stimulated with increasing doses of PRL, lysed and immunoprecipitated with anti-fyn specific antibody. Then PI3-kinase activity was measured as the i... hiện toàn bộ
Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy
Journal of Molecular Endocrinology - Tập 28 Số 3 - Trang 213-223 - 2002
Masayo Fujita, Sumito Ogawa, Hideoki Fukuoka, Tatsuya Tsukui, N Nemoto, Osamu Tsutsumi, Yasuyoshi Ouchi, Satoshi Inoue
During pregnancy, the uterus shows marked morphological and physiological changes under the regulation of ovarian steroid. To elucidate the molecular cues of these changes, we tried to identify the transcripts differentially expressed in the pregnant rat uterus by using the suppression subtractive hybridization method. Seven independent clones were isolated and one of the up-regulated genes was se... hiện toàn bộ
EXPRESSION OF THE RAT AMYLIN (IAPP / DAP) GENE.
Journal of Molecular Endocrinology - Tập 3 Số 1 - Trang R1-R4 - 1989
G. Ferrier, A.M. Pierson, Philip Jones, S. R. Bloom, Samia I. Girgis, S. Legon
ABSTRACT We have used the polymerase chain reaction with mixed sequence primers to generate a probe for rat amylin and have used this to detect expression in various rat tissues. Amylin mRNA is found in greatest concentrations in the pancreas where a single mRNA species can be detected giving a hybridisation signal intensity approximately 10% that of insulin mRNA. When the beta cell population was... hiện toàn bộ
Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct
Journal of Molecular Endocrinology - Tập 32 Số 3 - Trang 615-625 - 2004
Akinobu Okada, Yoshihiro Ohta, S.L. Brody, Hajime Watanabe, Andrée Krust, Pierre Chambon, Taisen Iguchi
Estrogen regulates proliferation and differentiation of epithelial cells in the mammalian oviduct, but pathways for cell-specific differentiation are not well understood. In the epithelial cells of the developing rat oviduct, we found estrogen receptor (ER) alpha is expressed at birth and persists in all cells through neonatal day (ND) 7 when ciliated cells appear. To determine a specific function... hiện toàn bộ
Changes in expression of neurohypophysial hormone genes during spawning migration in chum salmon, Oncorhynchus keta
Journal of Molecular Endocrinology - Tập 18 Số 1 - Trang 49-55 - 1997
Shûichi Hiraoka, Hideya Ando, Masatoshi Ban, Hiroshi Ueda, Akihisa Urano
ABSTRACT We analyzed changes in the hypothalamic levels of vasotocin (VT) and isotocin (IT) mRNA in chum salmon during spawning migration to the Ishikari river. The fish were caught at Atsuta, a fisherman's village facing the Ishikari bay, and at Chitose, an upstream branch of the Ishikari river. The former are referred to as sea water (SW) fish, and the latter as freshwater (FW) fish. The levels ... hiện toàn bộ
Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin
Journal of Molecular Endocrinology - Tập 18 Số 1 - Trang 77-85 - 1997
SM Luoh, Francesco Di Marco, Nathan W. Levin, Mark Armanini, M-H Xie, Carl P. Nelson, G L Bennett, Mark Mon‐Williams, Steven A. Spencer, Austin Gurney, Frédéric J. de Sauvage
ABSTRACT Leptin, the product of the ob gene, is a hormone secreted by fat cells which is primarily involved in the regulation of body weight. We have generated a leptin immunoadhesin (leptin-IgG) which was more potent than leptin alone at reducing body weight and food intake when injected into ob/ob mice. This molecule was used to identify high affinity binding sites on human embryonic 293 kidney ... hiện toàn bộ
PKC and ERK mediate GH-stimulated lipolysis
Journal of Molecular Endocrinology - Tập 51 Số 2 - Trang 213-224 - 2013
Heather E. Bergan, Jeffrey D. Kittilson, Mark A. Sheridan
GH regulates several physiological processes in vertebrates, including the promotion of growth, an anabolic process, and the mobilization of stored lipids, a catabolic process. In this study, we used hepatocytes isolated from rainbow trout (Oncorhynchus mykiss) as a model to examine the mechanism of GH action on lipolysis. GH stimulated lipolysis as measured by increased glycerol release in both a... hiện toàn bộ
The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream
Journal of Molecular Endocrinology - Tập 36 Số 1 - Trang 23-40 - 2006
Baowei Jiao, Xigui Huang, Chi Bun Chan, Li Zhang, Deshou Wang, Christopher H.K. Cheng
Two genomic contigs of putative growth hormone receptors (GHRs) were identified in fugu and zebrafish genomes by in silico analysis, suggesting the presence of two GHR subtypes in a single teleost species. We have tested this hypothesis by cloning the full-length cDNA sequence of a second GHR subtype from the black seabream in which the first GHR subtype had been previously reported by us. In addi... hiện toàn bộ
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