Transcriptional coregulator RIP140: an essential regulator of physiology

Journal of Molecular Endocrinology - Tập 58 Số 3 - Trang R147-R158 - 2017
Jaya Nautiyal1
1Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, UK

Tóm tắt

Transcriptional coregulators drive gene regulatory decisions in the transcriptional space. Although transcription factors including all nuclear receptors provide a docking platform for coregulators to bind, these proteins bring enzymatic capabilities to the gene regulatory sites. RIP140 is a transcriptional coregulator essential for several physiological processes, and aberrations in its function may lead to diseased states. Unlike several other coregulators that are known either for their coactivating or corepressing roles, in gene regulation, RIP140 is capable of acting both as a coactivator and a corepressor. The role of RIP140 in female reproductive axis and recent findings of its role in carcinogenesis and adipose biology have been summarised.

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Tài liệu tham khảo

10.1016/j.puhe.2009.07.009

Aziz, 2015, Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo, Oncotarget, 6, 39714, 10.18632/oncotarget.5356

10.1210/mend-5-5-619

10.1002/hep.22383

Brou, 1993, Distinct TFIID complexes mediate the effect of different transcriptional activators, EMBO Journal, 12, 489, 10.1002/j.1460-2075.1993.tb05681.x

10.1038/nature12113

10.1093/nar/gkh524

10.1073/pnas.91.21.10009

Cavailles, 1995, Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor, EMBO Journal, 14, 3741, 10.1002/j.1460-2075.1995.tb00044.x

10.1210/mend-5-1-100

10.1038/nri3071

10.1016/j.mce.2004.07.001

10.1016/j.mce.2012.03.023

10.1074/jbc.M313906200

10.1128/MCB.25.21.9383-9391.2005

10.1016/j.tem.2006.06.008

10.1210/me.11.9.1332

10.1056/NEJMoa0810780

10.1530/JME-14-0080

10.1146/annurev-med-051812-145316

10.1016/j.cell.2012.06.013

10.1210/me.2007-0103

10.1371/journal.pone.0035839

10.1210/me.2012-1351

10.1111/j.1601-183X.2011.00731.x

Feng, 2014, Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death, Nature Communications, 5, 4487, 10.1038/ncomms5487

Feng, 2015, Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation, Brain, Behavior, and Immunity, 46, 270, 10.1016/j.bbi.2015.02.008

10.3945/ajcn.110.001917

Ferreira, 2014, New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers, Human Mutation, 35, 1514, 10.1002/humu.22700

10.1093/cvr/cvp418

Fritah, 2011, Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function, Cardiovascular Research, 86, 443, 10.1093/cvr/cvp418

10.1371/journal.pone.0032520

10.1038/nature08497

10.1038/ni.2419

Gibson, 2016, The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis, Nature Genetics, 48, 848, 10.1038/ng.3602

10.1016/0092-8674(90)90139-6

10.1074/mcp.M500236-MCP200

10.1093/nar/gkl1147

10.1126/science.8197458

10.1128/MCB.00504-08

10.1186/bcr2839

10.1038/42750

10.1038/387043a0

10.1038/leu.2011.125

10.1210/me.2007-0213

10.1016/j.cellsig.2008.07.001

10.1038/ni.2238

10.2337/db14-1117

10.1074/jbc.272.47.29821

10.1016/0092-8674(94)90404-9

10.1038/msb.2010.109

10.1210/me.11.2.193

10.1016/j.tibs.2011.01.001

10.1210/me.2013-1254

Lapierre, 2014, RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis, Journal of Clinical Investigation, 124, 1899, 10.1172/JCI65178

Lapierre, 2015, Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia, Journal of Hematology and Oncology, 8, 20, 10.1186/s13045-015-0116-6

Lapierre, 2015, The emerging role of the transcriptional coregulator RIP140 in solid tumors, Biochimica et Biophysica Acta, 1856, 144

10.2353/ajpath.2007.061010

10.1016/S0378-1119(00)00024-X

10.1210/en.143.2.700

10.1073/pnas.0401013101

10.2337/db14-0619

Liu, 2015, Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance, Adipocyte, 4, 123, 10.4161/21623945.2014.981438

Liu, 2015, M1-M2 balancing act in white adipose tissue browning – a new role for RIP140, Adipocyte, 4, 146, 10.4161/21623945.2014.981428

10.1016/j.molcel.2007.08.012

10.1172/JCI29881

10.1530/JME-13-0227

10.1038/nri2448

10.1016/S0092-8674(00)80218-4

10.1210/en.2010-0081

10.1016/j.tem.2013.05.001

10.1242/dev.085720

10.1016/j.ceb.2008.04.005

10.1210/en.2003-0487

10.1210/en.2002-220435

10.1126/science.1230721

10.1200/JCO.2005.03.2755

10.1126/science.270.5240.1354

10.1126/science.1092463

10.1093/nar/gkp780

10.1210/me.2011-1072

10.1172/JCI26040

10.1016/S0092-8674(00)81410-5

10.1055/s-2007-980217

10.1172/JCI41350

10.1210/me.2015-1005

Rosell, 2011, Role of nuclear receptor corepressor RIP140 in metabolic syndrome, Biochimica et Biophysica Acta, 1812, 919, 10.1016/j.bbadis.2010.12.016

10.1158/0008-5472.CAN-13-3429

10.1016/j.cmet.2007.08.004

10.1210/me.2005-0504

10.1016/j.tem.2014.05.004

Stern, 2016, Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk, Cell Metabolism, 23, 770, 10.1016/j.cmet.2016.04.011

10.1242/dev.01966

10.1038/42652

10.1210/me.12.6.864

10.1042/BJ20090915

10.1210/en.2005-0348

van’t Veer, 2006, The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia, Haematologica, 91, 56

10.1128/MCB.21.18.6181-6188.2001

10.1152/ajpendo.00249.2011

10.1074/jbc.M004821200

10.1038/82183

Wieland, 1991, Interference and synergism of glucocorticoid receptor and octamer factors, EMBO Journal, 10, 2513, 10.1002/j.1460-2075.1991.tb07791.x

Wong, 2014, Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation, American Journal of Clinical and Experimental Urology, 2, 169

10.1038/nature12034

10.1074/jbc.R110.193367

10.1073/pnas.1121113109

10.1182/blood-2007-11-121699