Journal of Mammary Gland Biology and Neoplasia

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Methicillin Resistant S. aureus in Human and Bovine Mastitis
Journal of Mammary Gland Biology and Neoplasia - Tập 16 - Trang 373-382 - 2011
Mark A. Holmes, Ruth N. Zadoks
Staphylococcus aureus is a ubiquitous organism that causes a variety of diseases including mastitis in cattle and humans. High-level resistance of S. aureus to β-lactams conferred by a mecA gene encoding a modified penicillin binding protein (PBP2a) was first observed in the early 1960’s. These methicillin resistant S. aureus (MRSA) have been responsible for both hospital ...... hiện toàn bộ
The National Mastitis Council: A Global Organization for Mastitis Control and Milk Quality, 50 Years and Beyond
Journal of Mammary Gland Biology and Neoplasia - - 2014
John R. Middleton, A.I. Saeman, L.K. Fox, Jason E. Lombard, J.S. Hogan, Kenneth L. Smith
Transcellular Calcium Transport in Mammary Epithelial Cells
Journal of Mammary Gland Biology and Neoplasia - Tập 12 - Trang 223-235 - 2007
Joshua N. VanHouten, John J. Wysolmerski
The time-honored paradigm for mammary gland transepithelial calcium transport into milk is centered on the view that most, if not all, calcium enters milk through the secretory pathway, and no ionic calcium directly crosses the apical plasma membrane. Data from several recent studies all strongly suggest that most calcium, in fact, is extruded across the apical plasma membrane directly by the plas...... hiện toàn bộ
Microenvironmental Influences that Drive Progression from Benign Breast Disease to Invasive Breast Cancer
Journal of Mammary Gland Biology and Neoplasia - - 2010
Magdalena A. Cichon, Amy C. Degnim, Daniel W. Visscher, Derek C. Radisky
Growth factor and sex steroid interactions in breast cancer
Journal of Mammary Gland Biology and Neoplasia - Tập 1 - Trang 189-198 - 1996
Nicholas J. Kenney, Robert B. Dickson
Mitogenic and inhibitory growth factors and steroid ovarian hormones play important roles as selective modulators of normal mammary development and in the onset and the progression of human breast cancer. The focus of this article is to review past and current research on the interactions of these two classes of effectors in mammary gland development and neoplasia. Steroid hormones regulate synthe...... hiện toàn bộ
Insulin and IGFs in Obesity-Related Breast Cancer
Journal of Mammary Gland Biology and Neoplasia - Tập 18 - Trang 277-289 - 2013
Valentina Belardi, Emily J. Gallagher, Ruslan Novosyadlyy, Derek LeRoith
Obesity and the Metabolic Syndrome are associated with multiple factors that may cause an increased risk for cancer and cancer-related mortality. Factors involved include hyperinsulinemia, hyperglycemia, hyperlipidemia and IGFs. Insulin resistance is also associated with alterations in the levels of proinflammatory cytokines, chemokines, adipokines (leptin, adiponectin) that may also be contributi...... hiện toàn bộ
Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing
Journal of Mammary Gland Biology and Neoplasia - Tập 24 - Trang 47-59 - 2018
Kyung Hyun Yoo, Lothar Hennighausen, Ha Youn Shin
Recent advances in genome-wide sequencing technologies have provided researchers with unprecedented opportunities to discover the genomic structures of gene regulatory units in living organisms. In particular, the integration of ChIP-seq, RNA-seq, and DNase-seq techniques has facilitated the mapping of a new class of regulatory elements. These elements, called super-enhancers, can regulate cell-ty...... hiện toàn bộ
A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity
Journal of Mammary Gland Biology and Neoplasia - - 2012
Frances L. Shaw, Hannah Harrison, Katherine Spence, Matthew P. Ablett, Bruno M. Simões, Gillian Farnie, Robert B. Clarke
Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is mammary tissue, and the mammosphere assay has been used in both normal tissue and...... hiện toàn bộ
The mammary gland: A unique organ for the study of development and tumorigenesis
Journal of Mammary Gland Biology and Neoplasia - - 1996
Daniel Medina
New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
Journal of Mammary Gland Biology and Neoplasia - Tập 20 - Trang 109-119 - 2015
Honor J. Hugo, C. Saunders, R. G. Ramsay, E. W. Thompson
The medicinal use of aspirin stretches back to ancient times, before it was manufactured in its pure form in the late 19th century. Its accepted mechanistic target, cyclooxygenase (COX), was discovered in the 1970s and since this landmark discovery, the therapeutic application of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has increased dramatically. The most significant benef...... hiện toàn bộ
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