Journal of Mammary Gland Biology and Neoplasia
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Methicillin Resistant S. aureus in Human and Bovine Mastitis
Journal of Mammary Gland Biology and Neoplasia - Tập 16 - Trang 373-382 - 2011
Staphylococcus aureus is a ubiquitous organism that causes a variety of diseases
including mastitis in cattle and humans. High-level resistance of S. aureus to
β-lactams conferred by a mecA gene encoding a modified penicillin binding
protein (PBP2a) was first observed in the early 1960’s. These methicillin
resistant S. aureus (MRSA) have been responsible for both hospital acquired
infections (HA-M...
The National Mastitis Council: A Global Organization for Mastitis Control and Milk Quality, 50 Years and Beyond
Journal of Mammary Gland Biology and Neoplasia - - 2014
Transcellular Calcium Transport in Mammary Epithelial Cells
Journal of Mammary Gland Biology and Neoplasia - Tập 12 - Trang 223-235 - 2007
The time-honored paradigm for mammary gland transepithelial calcium transport
into milk is centered on the view that most, if not all, calcium enters milk
through the secretory pathway, and no ionic calcium directly crosses the apical
plasma membrane. Data from several recent studies all strongly suggest that most
calcium, in fact, is extruded across the apical plasma membrane directly by the
plas...
Growth factor and sex steroid interactions in breast cancer
Journal of Mammary Gland Biology and Neoplasia - Tập 1 - Trang 189-198 - 1996
Mitogenic and inhibitory growth factors and steroid ovarian hormones play
important roles as selective modulators of normal mammary development and in the
onset and the progression of human breast cancer. The focus of this article is
to review past and current research on the interactions of these two classes of
effectors in mammary gland development and neoplasia. Steroid hormones regulate
synthe...
Insulin and IGFs in Obesity-Related Breast Cancer
Journal of Mammary Gland Biology and Neoplasia - Tập 18 - Trang 277-289 - 2013
Obesity and the Metabolic Syndrome are associated with multiple factors that may
cause an increased risk for cancer and cancer-related mortality. Factors
involved include hyperinsulinemia, hyperglycemia, hyperlipidemia and IGFs.
Insulin resistance is also associated with alterations in the levels of
proinflammatory cytokines, chemokines, adipokines (leptin, adiponectin) that may
also be contributi...
Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing
Journal of Mammary Gland Biology and Neoplasia - Tập 24 - Trang 47-59 - 2018
Recent advances in genome-wide sequencing technologies have provided researchers
with unprecedented opportunities to discover the genomic structures of gene
regulatory units in living organisms. In particular, the integration of
ChIP-seq, RNA-seq, and DNase-seq techniques has facilitated the mapping of a new
class of regulatory elements. These elements, called super-enhancers, can
regulate cell-ty...
A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity
Journal of Mammary Gland Biology and Neoplasia - - 2012
Since the discovery that neural tissue contains a population of stem cells that
form neurospheres in vitro, sphere-forming assays have been adapted for use with
a number of different tissue types for the quantification of stem cell activity
and self-renewal. One tissue type widely used for stem cell investigations is
mammary tissue, and the mammosphere assay has been used in both normal tissue
and...
The mammary gland: A unique organ for the study of development and tumorigenesis
Journal of Mammary Gland Biology and Neoplasia - - 1996
New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
Journal of Mammary Gland Biology and Neoplasia - Tập 20 - Trang 109-119 - 2015
The medicinal use of aspirin stretches back to ancient times, before it was
manufactured in its pure form in the late 19th century. Its accepted mechanistic
target, cyclooxygenase (COX), was discovered in the 1970s and since this
landmark discovery, the therapeutic application of aspirin and other
non-steroidal anti-inflammatory drugs (NSAIDs) has increased dramatically. The
most significant benef...
MTA Family of Transcriptional Metaregulators in Mammary Gland Morphogenesis and Breast Cancer
Journal of Mammary Gland Biology and Neoplasia - - 2007
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