Journal of Mammary Gland Biology and Neoplasia
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Insulin and IGFs in Obesity-Related Breast Cancer
Journal of Mammary Gland Biology and Neoplasia - Tập 18 - Trang 277-289 - 2013
Obesity and the Metabolic Syndrome are associated with multiple factors that may cause an increased risk for cancer and cancer-related mortality. Factors involved include hyperinsulinemia, hyperglycemia, hyperlipidemia and IGFs. Insulin resistance is also associated with alterations in the levels of proinflammatory cytokines, chemokines, adipokines (leptin, adiponectin) that may also be contributi......
Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing
Journal of Mammary Gland Biology and Neoplasia - Tập 24 - Trang 47-59 - 2018
Recent advances in genome-wide sequencing technologies have provided researchers with unprecedented opportunities to discover the genomic structures of gene regulatory units in living organisms. In particular, the integration of ChIP-seq, RNA-seq, and DNase-seq techniques has facilitated the mapping of a new class of regulatory elements. These elements, called super-enhancers, can regulate cell-ty......
A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity
Journal of Mammary Gland Biology and Neoplasia - - 2012
Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is mammary tissue, and the mammosphere assay has been used in both normal tissue and......
New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
Journal of Mammary Gland Biology and Neoplasia - Tập 20 - Trang 109-119 - 2015
The medicinal use of aspirin stretches back to ancient times, before it was manufactured in its pure form in the late 19th century. Its accepted mechanistic target, cyclooxygenase (COX), was discovered in the 1970s and since this landmark discovery, the therapeutic application of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has increased dramatically. The most significant benef......
Longitudinal analysis of bovine mammary gland development
Journal of Mammary Gland Biology and Neoplasia - Tập 28 - Trang 1-11 - 2023
Many studies on bovine mammary glands focus on one stage of development. Often missing in those studies are repeated measures of development from the same animals. As milk production is directly affected by amount of parenchymal tissue within the udder, understanding mammary gland growth along with visualization of its structures during development is essential. Therefore, analysis of ultrasound a......
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an AuthorAbstract The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the developing mammary glands, where its members play an essential role in translating hormone signals into local effects. While our understanding of these processes stems mostly from mouse models, there is the poten... ...
Journal of Mammary Gland Biology and Neoplasia - - 2023
Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors
Journal of Mammary Gland Biology and Neoplasia - Tập 28 - Trang 1-15 - 2023
The extracellular matrix (ECM) is biochemically and biomechanically important for the structure and function of the mammary gland, which undergoes vast structural changes throughout pubertal and reproductive development. Although hyaluronan (HA) is a ubiquitous glycosaminoglycan (GAG) of the mammary gland ECM, extensive characterization of HA deposition in the mammary gland is lacking. Understandi......
Retraction Note to: Roles of MicroRNAs and Other Non-coding RNAs in Breast Cancer Metastasis
Journal of Mammary Gland Biology and Neoplasia - - 2016
Characterizing the Tumor Immune Microenvironment with Tyramide-Based Multiplex Immunofluorescence
Journal of Mammary Gland Biology and Neoplasia - Tập 25 - Trang 417-432 - 2021
Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection of multiple markers with a nuclear counterstain on a single tissue section. Recent studies have demonstrated that mIF is becoming an important tool for immune profiling the tumor microenvironment, further advancing our understanding of the interplay between cancer and the immune system, and identifying predictive bioma......
The Mammary Gland as a Bioreactor: Expression, Processing, and Production of Recombinant Proteins
Journal of Mammary Gland Biology and Neoplasia - Tập 3 - Trang 337-350 - 1998
A variety of transgenic animal species are beingused to produce recombinant proteins. The generalapproach is to target the expression of the desiredprotein to the mammary gland using regulatory elements derived from a milk protein gene and thencollect and purify the product from milk. Promotersequences from a number of different milk protein geneshave been used to target expression to the mammaryg......
Tổng số: 631
- 1
- 2
- 3
- 4
- 5
- 6
- 10