Journal of Internal Medicine

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Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project
Journal of Internal Medicine - Tập 281 Số 3 - Trang 300-310 - 2017
Michail Katsoulis, Vassiliki Benetou, Tina Karapetyan, Diane Feskanich, Francine Grodstein, U Pettersson, Sture Eriksson, Tom Wilsgaard, Lone Jørgensen, Luai A. Ahmed, Ben Schöttker, Hermann Brenner, Andrea Bellavia, Alicja Wolk, Carl Lachat, Bernardine H. Stegeman, Martin Bobák, Paolo Boffetta, Hanno Ulmer
AbstractBackgroundHip fractures are associated with diminished quality of life and survival especially amongst the elderly.ObjectiveAll‐cause mortality after hip fracture was investigated to assess its magnitude.Methods... hiện toàn bộ
Manipulating angiogenesis in medicine
Journal of Internal Medicine - Tập 255 Số 5 - Trang 538-561 - 2004
Peter Carmeliet
Abstract.Blood vessels nourish organs with vital nutrients and oxygen and, thus, new vessels form when the embryo needs to grow or wounds are to heal. However, forming new blood vessels is a complex and delicate process, which, unfortunately, is often derailed. Thus, when insufficient vessels form, the tissue becomes ischaemic and stops to function adequately. Conv...... hiện toàn bộ
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine
Journal of Internal Medicine - Tập 271 Số 2 - Trang 111-121 - 2012
Qi Tian, Nathan D. Price, Leroy Hood
Abstract.  Tian Q, Price ND, Hood L (Institute for Systems Biology, Seattle, WA, USA). Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine (Key Symposium). J Intern Med 2012; 271: 111–121.A grand challenge impeding optimal treatment outc...... hiện toàn bộ
Adrenoceptor genes in human obesity
Journal of Internal Medicine - Tập 245 Số 6 - Trang 667-672 - 1999
Peter Arner, Johan Hoffstedt
Abstract. Arner P, Hoffstedt J (Karolinska Institute, Huddinge Hospital, Stockholm, Sweden). Adrenoceptor genes in human obesity. (Minisymposium: Genes & Obesity). J Intern Med 1999; 245: 667–672.The genes causing obesity in rodent models have been characterized, but do ...... hiện toàn bộ
Diabetes mellitus as a prothrombotic condition
Journal of Internal Medicine - Tập 262 Số 2 - Trang 157-172 - 2007
Peter J. Grant
Abstract.Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The risk of myocardial infarction (MI) is 3‐5 fold higher in Type 2 DM and a DM subject with no history of MI has the same risk as a non‐DM subject with a past history of MI. In tota...... hiện toàn bộ
Immunomodulation by mesenchymal stem cells and clinical experience
Journal of Internal Medicine - Tập 262 Số 5 - Trang 509-525 - 2007
Katarina Le Blanc, O Ringdén
AbstractMesenchymal stem cells (MSCs) from adult marrow can differentiate in vitro and in vivo into various cell types, such as bone, fat and cartilage. MSCs preferentially home to damaged tissue and may have therapeutic potential. In vitro data suggest that MSCs have low inherent immu...... hiện toàn bộ
Nonalcoholic fatty liver disease increases risk of incident advanced chronic kidney disease: a propensity‐matched cohort study
Journal of Internal Medicine - Tập 286 Số 6 - Trang 711-722 - 2019
Haesuk Park, Ghadeer K. Dawwas, Xinyue Liu, Mindie H. Nguyen
AbstractBackgroundAs the prevalence of nonalcoholic fatty liver disease (NAFLD) escalates, understanding its potential impact on the development of chronic kidney disease (CKD) is needed.ObjectiveTo determine the longitudinal association of NAFLD with the development o...... hiện toàn bộ
VEGFA and tumour angiogenesis
Journal of Internal Medicine - Tập 273 Số 2 - Trang 114-127 - 2013
Lena Claesson‐Welsh, Michael Welsh
AbstractIn this review we summarize the current understanding of signal transduction downstream of vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2, and the relationship between these signal transduction pathways and the ha...... hiện toàn bộ
Constitutive RET tyrosine kinase activation in hereditary medullary thyroid cancer: clinical opportunities
Journal of Internal Medicine - Tập 266 Số 1 - Trang 114-125 - 2009
Andreas Machens, Kerstin Lorenz, Henning Dralle
Abstract.The ground‐breaking discovery of genotype–phenotype relationships in hereditary medullary thyroid cancer has greatly facilitated early prophylactic thyroidectomy. Its timing depends not solely on a positive gene test but, more importantly, on the type of the REarranged during Transfection (RET) mutation...... hiện toàn bộ
Idiopathic environmental intolerances (formerly multiple chemical sensitivity) psychiatric perspectives
Journal of Internal Medicine - Tập 250 Số 4 - Trang 309-321 - 2001
S. Bornschein, Hans Förstl, Thomas Zilker
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