Journal of General Physiology

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On the Mechanism of Respiratory Control
Journal of General Physiology - Tập 49 Số 1 - Trang 149-162 - 1965
Ronald A. Butow, Efraim Racker
Control of oxidation is the key mechanism in the regulation of energy metabolism. In glycolysis the oxidation of glyceraldehyde-3-phosphate is controlled by DPNH, which inhibits glyceraldehyde-3-phosphate dehydrogenase. In oxidative phosphorylation the inhibition of electron flow from DPNH to oxygen, called "respiratory control," is the subject of this paper. After a discussion of the phys...... hiện toàn bộ
Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons
Journal of General Physiology - Tập 129 Số 1 - Trang 57-77 - 2007
Bertrand Coste, Marcel Crest, Patrick Delmas
Low voltage–activated (LVA) T-type Ca2+ (ICaT) and NaN/Nav1.9 currents regulate DRG neurons by setting the threshold for the action potential. Although alterations in these channels have been implicated in a variety of pathological pain states, their roles in processing sensory information remain poorly understood. Here, we carried out a detailed characterization of LVA currents in DRG neu...... hiện toàn bộ
The Light Peak of the Electroretinogram Is Dependent on Voltage-gated Calcium Channels and Antagonized by Bestrophin (Best-1)
Journal of General Physiology - Tập 127 Số 5 - Trang 577-589 - 2006
Lihua Y. Marmorstein, Jiang Wu, P. J. McLaughlin, John Yocom, Michael Karl, Rudgar Neussert, Soenke Wimmers, J. Brett Stanton, Ronald G. Gregg, Olaf Strauß, Neal S. Peachey, Alan D. Marmorstein
Mutations in VMD2, encoding bestrophin (best-1), cause Best vitelliform macular dystrophy (BMD), adult-onset vitelliform macular dystrophy (AVMD), and autosomal dominant vitreoretinochoroidopathy (ADVIRC). BMD is distinguished from AVMD by a diminished electrooculogram light peak (LP) in the absence of changes in the flash electroretinogram. Although the LP is thought to be generated by be...... hiện toàn bộ
Blockage of gallbladder tight junction cation-selective channels by 2,4,6-triaminopyrimidinium (TAP).
Journal of General Physiology - Tập 66 Số 1 - Trang 97-115 - 1975
Julio H. Moreno
The organic cation 2,4,6-triaminopyrimidinium (TAP) specifically inhibits Na+ passive permeation (PNa) across gallbladder, small intestine, and choroid plexus without detectable effect on the Cl(-) permeability, indicating that Na+ and Cl(-) follow different permeation pathways. In bullfrog gallbladder, where it was examined in greater detail, the effect of TAP was shown to be: (a) complet...... hiện toàn bộ
THE CALCULATION OF TRANSFER RATES IN TWO COMPARTMENT SYSTEMS NOT IN DYNAMIC EQUILIBRIUM
Journal of General Physiology - Tập 41 Số 6 - Trang 1135-1152 - 1958
Eugene Y. Berger, J. Murray Steele
Dynamic equilibrium in a biological system implies that the compartment under study does not change in size during the period of observation. In many biological systems there are, however, net changes with time and this report deals with the mathematical treatment necessary to calculate unequal rates of inflow and outflow. A method is presented for the calcu...... hiện toàn bộ
Spontaneous Transient Outward Currents Arise from Microdomains Where BK Channels Are Exposed to a Mean Ca2+ Concentration on the Order of 10 μM during a Ca2+ Spark
Journal of General Physiology - Tập 120 Số 1 - Trang 15-27 - 2002
Ronghua ZhuGe, Kevin E. Fogarty, Richard A. Tuft, John V. Walsh
Ca2+ sparks are small, localized cytosolic Ca2+ transients due to Ca2+ release from sarcoplasmic reticulum through ryanodine receptors. In smooth muscle, Ca2+ sparks activate large conductance Ca2+-activated K+ channels (BK channels) in the spark microdomain, thus generating spontaneous transient outward currents (STOCs). The purpose of the present study is to determine experimentally the ...... hiện toàn bộ
A malignant hyperthermia–inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels
Journal of General Physiology - Tập 135 Số 6 - Trang 629-640 - 2010
Roger A. Bannister, É. Estève, José M. Eltit, Isaac N. Pessah, Paul D. Allen, José R. López, Kurt G. Beam
Bidirectional communication between the 1,4-dihydropyridine receptor (DHPR) in the plasma membrane and the type 1 ryanodine receptor (RYR1) in the sarcoplasmic reticulum (SR) is responsible for both skeletal-type excitation–contraction coupling (voltage-gated Ca2+ release from the SR) and increased amplitude of L-type Ca2+ current via the DHPR. Because the DHPR and RYR1 are functionally co...... hiện toàn bộ
Interdomain Interactions within Ryanodine Receptors Regulate Ca2+ Spark Frequency in Skeletal Muscle
Journal of General Physiology - Tập 119 Số 1 - Trang 15-32 - 2002
Alexander Shtifman, Christopher W. Ward, Takeshi Yamamoto, Jianli Wang, Beth A. Olbinski, Héctor H. Valdivia, Noriaki Ikemoto, Martin F. Schneider
DP4 is a 36-residue synthetic peptide that corresponds to the Leu2442-Pro2477 region of RyR1 that contains the reported malignant hyperthermia (MH) mutation site. It has been proposed that DP4 disrupts the normal interdomain interactions that stabilize the closed state of the Ca2+ release channel (Yamamoto, T., R. El-Hayek, and N. Ikemoto. 2000. J. Biol. Chem. 275:11618–11625). We have inv...... hiện toàn bộ
Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations.
Journal of General Physiology - Tập 107 Số 4 - Trang 459-472 - 1996
Michael Rubart, J B Patlak, Mark T. Nelson
Single Ca2+ channel and whole cell currents were measured in smooth muscle cells dissociated from resistance-sized (100-microns diameter) rat cerebral arteries. We sought to quantify the magnitude of Ca2+ channel currents and activity under the putative physiological conditions of these cells: 2 mM [Ca2+]o, steady depolarizations to potentials between -50 and -20 mV, and (where possible) w...... hiện toàn bộ
Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium.
Journal of General Physiology - Tập 104 Số 5 - Trang 821-856 - 1994
Ilya Bezprozvanny, Barbara E. Ehrlich
The conduction properties of inositol (1,4,5)-trisphosphate (InsP3)-gated calcium (Ca) channels (InsP3R) from canine cerebellum for divalent cations and the regulation of the channels by intraluminal Ca were studied using channels reconstituted into planar lipid bilayers. Analysis of single-channel recordings performed with different divalent cations present at 55 mM on the trans (intralum...... hiện toàn bộ
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