Journal of General Physiology

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SYNTHESIS OF PROTEIN IN THE PANCREAS
Journal of General Physiology - Tập 37 Số 2 - Trang 157-175 - 1953
V. G. Allfrey, Marie M. Daly, A. E. Mirsky
1. The ribonucleoprotein of the microsome fraction which sediments at 40,000 R.P.M. as a pellet (and which is referred to as the pellet material) has been studied with reference to its role in protein synthesis in the pancreas. 2. In pellet material nucleic acid and protein form a definite complex as shown by its electrophoretic behavior and unchanging compo...... hiện toàn bộ
On the Mechanism of Respiratory Control
Journal of General Physiology - Tập 49 Số 1 - Trang 149-162 - 1965
Ronald A. Butow, Efraim Racker
Control of oxidation is the key mechanism in the regulation of energy metabolism. In glycolysis the oxidation of glyceraldehyde-3-phosphate is controlled by DPNH, which inhibits glyceraldehyde-3-phosphate dehydrogenase. In oxidative phosphorylation the inhibition of electron flow from DPNH to oxygen, called "respiratory control," is the subject of this paper. After a discussion of the phys...... hiện toàn bộ
The Frequency of Calcium Oscillations Induced by 5-HT, ACH, and KCl Determine the Contraction of Smooth Muscle Cells of Intrapulmonary Bronchioles
Journal of General Physiology - Tập 125 Số 6 - Trang 535-553 - 2005
Jose F. Perez‐Zoghbi, Michael J. Sanderson
Increased resistance of airways or blood vessels within the lung is associated with asthma or pulmonary hypertension and results from contraction of smooth muscle cells (SMCs). To study the mechanisms regulating these contractions, we developed a mouse lung slice preparation containing bronchioles and arterioles and used phase-contrast and confocal microscopy to correlate the contractile r...... hiện toàn bộ
Localization of Hydrogen Ion and Chloride Ion Fluxes in Nitella
Journal of General Physiology - Tập 54 Số 3 - Trang 397-414 - 1969
Donald G. Spear, June K. Barr, Charles Barr
Alternating bands of acid and base formation have been detected along the length of the internodal cell of Nitella clavata when it is illuminated, while in the dark this phenomenon is minimal. Chloride influx occurs only or largely in the acid-extruding regions, and this is also a light-dependent ion movement. Chloride efflux is slightly dependent on illumination and is not localized as ar...... hiện toàn bộ
Effects of tetraethylammonium on potassium currents in a molluscan neurons.
Journal of General Physiology - Tập 78 Số 1 - Trang 87-110 - 1981
Anton Hermann, A. L. F. Gorman
The effects of tetraethylammonium (TEA) on the delayed K+ current and on the Ca2+-activated K+ current of the Aplysia pacemaker neurons R-15 and L-6 were studied. The delayed outward K+ current was measured in Ca2+-free ASW containing tetrodotoxin (TTX), using brief depolarizing clamp pulses. External TEA blocks the delayed K+ current reversibly in a dose-dependent manner. The experimental...... hiện toàn bộ
THE ACTION POTENTIAL OF SPINAL AXONS IN VITRO
Journal of General Physiology - Tập 37 Số 4 - Trang 505-538 - 1954
Donald O. Rudin, George Eisenman
Despite the trauma of dissection and special metabolic requirements, the physiological properties of funiculi of the mammalian spinal cord can be studied in vitro. They are adequately oxygenated by diffusion at 0.88 atm. pO2 and remain in a functionally normal state for over 12 hours. The internal consistency of several kinds of data presented in this and th...... hiện toàn bộ
Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons
Journal of General Physiology - Tập 129 Số 1 - Trang 57-77 - 2007
Bertrand Coste, Marcel Crest, Patrick Delmas
Low voltage–activated (LVA) T-type Ca2+ (ICaT) and NaN/Nav1.9 currents regulate DRG neurons by setting the threshold for the action potential. Although alterations in these channels have been implicated in a variety of pathological pain states, their roles in processing sensory information remain poorly understood. Here, we carried out a detailed characterization of LVA currents in DRG neu...... hiện toàn bộ
The Light Peak of the Electroretinogram Is Dependent on Voltage-gated Calcium Channels and Antagonized by Bestrophin (Best-1)
Journal of General Physiology - Tập 127 Số 5 - Trang 577-589 - 2006
Lihua Y. Marmorstein, Jiang Wu, P. J. McLaughlin, John Yocom, Michael Karl, Rudgar Neussert, Soenke Wimmers, J. Brett Stanton, Ronald G. Gregg, Olaf Strauß, Neal S. Peachey, Alan D. Marmorstein
Mutations in VMD2, encoding bestrophin (best-1), cause Best vitelliform macular dystrophy (BMD), adult-onset vitelliform macular dystrophy (AVMD), and autosomal dominant vitreoretinochoroidopathy (ADVIRC). BMD is distinguished from AVMD by a diminished electrooculogram light peak (LP) in the absence of changes in the flash electroretinogram. Although the LP is thought to be generated by be...... hiện toàn bộ
Voltage-dependent Anion Channel-1 (VDAC-1) Contributes to ATP Release and Cell Volume Regulation in Murine Cells
Journal of General Physiology - Tập 124 Số 5 - Trang 513-526 - 2004
Seiko F. Okada, Wanda K. O’Neal, Pingbo Huang, Robert A. Nicholas, Lawrence E. Ostrowski, William J. Craigen, Eduardo R. Lazarowski, Richard C. Boucher
Extracellular ATP regulates several elements of the mucus clearance process important for pulmonary host defense. However, the mechanisms mediating ATP release onto airway surfaces remain unknown. Mitochondrial voltage-dependent anion channels (mt-VDACs) translocate a variety of metabolites, including ATP and ADP, across the mitochondrial outer membrane, and a plasmalemmal splice variant (...... hiện toàn bộ
Two rigor states in skinned crayfish single muscle fibers.
Journal of General Physiology - Tập 68 Số 3 - Trang 267-280 - 1976
Masataka Kawai, Philip W. Brandt
We studied the tension and stiffness of crayfish skinned single muscle fibers during and after the induction of rigor by removal of MgATP (substrate). We found that the rigor state is not unique but depends on the condition of the muscle before rigor. Fibers induced into rigor with a minimum of activation (low rigor) develop a small tension and moderate stiffness, while those entering rigo...... hiện toàn bộ
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