Journal of General Physiology
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SYNTHESIS OF PROTEIN IN THE PANCREAS
Journal of General Physiology - Tập 37 Số 2 - Trang 157-175 - 1953
1. The ribonucleoprotein of the microsome fraction which sediments at 40,000
R.P.M. as a pellet (and which is referred to as the pellet material) has been
studied with reference to its role in protein synthesis in the pancreas. 2. In
pellet material nucleic acid and protein form a definite complex as shown by its
electrophoretic behavior and unchanging composition under various conditions. 3.
Prot...
On the Mechanism of Respiratory Control
Journal of General Physiology - Tập 49 Số 1 - Trang 149-162 - 1965
Control of oxidation is the key mechanism in the regulation of energy
metabolism. In glycolysis the oxidation of glyceraldehyde-3-phosphate is
controlled by DPNH, which inhibits glyceraldehyde-3-phosphate dehydrogenase. In
oxidative phosphorylation the inhibition of electron flow from DPNH to oxygen,
called "respiratory control," is the subject of this paper. After a discussion
of the physiologica...
The Frequency of Calcium Oscillations Induced by 5-HT, ACH, and KCl Determine the Contraction of Smooth Muscle Cells of Intrapulmonary Bronchioles
Journal of General Physiology - Tập 125 Số 6 - Trang 535-553 - 2005
Increased resistance of airways or blood vessels within the lung is associated
with asthma or pulmonary hypertension and results from contraction of smooth
muscle cells (SMCs). To study the mechanisms regulating these contractions, we
developed a mouse lung slice preparation containing bronchioles and arterioles
and used phase-contrast and confocal microscopy to correlate the contractile
responses...
Localization of Hydrogen Ion and Chloride Ion Fluxes in Nitella
Journal of General Physiology - Tập 54 Số 3 - Trang 397-414 - 1969
Alternating bands of acid and base formation have been detected along the length
of the internodal cell of Nitella clavata when it is illuminated, while in the
dark this phenomenon is minimal. Chloride influx occurs only or largely in the
acid-extruding regions, and this is also a light-dependent ion movement.
Chloride efflux is slightly dependent on illumination and is not localized as
are H+ eff...
Effects of tetraethylammonium on potassium currents in a molluscan neurons.
Journal of General Physiology - Tập 78 Số 1 - Trang 87-110 - 1981
The effects of tetraethylammonium (TEA) on the delayed K+ current and on the
Ca2+-activated K+ current of the Aplysia pacemaker neurons R-15 and L-6 were
studied. The delayed outward K+ current was measured in Ca2+-free ASW containing
tetrodotoxin (TTX), using brief depolarizing clamp pulses. External TEA blocks
the delayed K+ current reversibly in a dose-dependent manner. The experimental
results...
THE ACTION POTENTIAL OF SPINAL AXONS IN VITRO
Journal of General Physiology - Tập 37 Số 4 - Trang 505-538 - 1954
Despite the trauma of dissection and special metabolic requirements, the
physiological properties of funiculi of the mammalian spinal cord can be studied
in vitro. They are adequately oxygenated by diffusion at 0.88 atm. pO2 and
remain in a functionally normal state for over 12 hours. The internal
consistency of several kinds of data presented in this and the foregoing papers
(5, 38) serves to cha...
Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons
Journal of General Physiology - Tập 129 Số 1 - Trang 57-77 - 2007
Low voltage–activated (LVA) T-type Ca2+ (ICaT) and NaN/Nav1.9 currents regulate
DRG neurons by setting the threshold for the action potential. Although
alterations in these channels have been implicated in a variety of pathological
pain states, their roles in processing sensory information remain poorly
understood. Here, we carried out a detailed characterization of LVA currents in
DRG neurons by ...
Voltage-dependent Anion Channel-1 (VDAC-1) Contributes to ATP Release and Cell Volume Regulation in Murine Cells
Journal of General Physiology - Tập 124 Số 5 - Trang 513-526 - 2004
Extracellular ATP regulates several elements of the mucus clearance process
important for pulmonary host defense. However, the mechanisms mediating ATP
release onto airway surfaces remain unknown. Mitochondrial voltage-dependent
anion channels (mt-VDACs) translocate a variety of metabolites, including ATP
and ADP, across the mitochondrial outer membrane, and a plasmalemmal splice
variant (pl-VDAC-...
Two rigor states in skinned crayfish single muscle fibers.
Journal of General Physiology - Tập 68 Số 3 - Trang 267-280 - 1976
We studied the tension and stiffness of crayfish skinned single muscle fibers
during and after the induction of rigor by removal of MgATP (substrate). We
found that the rigor state is not unique but depends on the condition of the
muscle before rigor. Fibers induced into rigor with a minimum of activation (low
rigor) develop a small tension and moderate stiffness, while those entering
rigor during...
THE CALCULATION OF TRANSFER RATES IN TWO COMPARTMENT SYSTEMS NOT IN DYNAMIC EQUILIBRIUM
Journal of General Physiology - Tập 41 Số 6 - Trang 1135-1152 - 1958
Dynamic equilibrium in a biological system implies that the compartment under
study does not change in size during the period of observation. In many
biological systems there are, however, net changes with time and this report
deals with the mathematical treatment necessary to calculate unequal rates of
inflow and outflow. A method is presented for the calculation of transfer rates
in a two compar...
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