Journal of General Physiology
SCOPUS (1918-1940,1942-2025)SCIE-ISI
0022-1295
1540-7748
Mỹ
Cơ quản chủ quản: ROCKEFELLER UNIV PRESS , Rockefeller University Press
Lĩnh vực:
Physiology
Các bài báo tiêu biểu
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
Tập 22 Số 1 - Trang 79-89 - 1938
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES
Tập 27 Số 1 - Trang 37-60 - 1943
Impedance and potential measurements have been made on a number of artificial
membranes. Impedance changes were determined as functions of current and of the
composition of the environmental solutions. It was shown that rectification is
present in asymmetrical systems and that it increases with the membrane
potential. The behavior in pairs of solutions of the same salt at different
concentrations ...
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.
Tập 69 Số 4 - Trang 497-515 - 1977
The properties of Na channels of the node of Ranvier are altered by neutral,
amine, and quaternary local anesthetic compounds. The kinetics of the Na
currents are governed by a composite of voltage- and time-dependent gating
processes with voltage- and time-dependent block of channels by drug.
Conventional measurements of steady-state sodium inactivation by use of 50-ms
prepulses show a large nega...
INDEPENDENT FUNCTIONS OF VIRAL PROTEIN AND NUCLEIC ACID IN GROWTH OF BACTERIOPHAGE
Tập 36 Số 1 - Trang 39-56 - 1952
1. Osmotic shock disrupts particles of phage T2 into material containing nearly
all the phage sulfur in a form precipitable by antiphage serum, and capable of
specific adsorption to bacteria. It releases into solution nearly all the phage
DNA in a form not precipitable by antiserum and not adsorbable to bacteria. The
sulfur-containing protein of the phage particle evidently makes up a membrane
tha...
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Tập 58 Số 4 - Trang 413-437 - 1971
A number of compounds related to TEA+ (tetraethylammoniumion) were injected into
squid axons and their effects on gK (the potassium conductance) were determined.
In most of these ions a quaternary nitrogen is surrounded by three ethyl groups
and a fourth group that is very hydrophobic. Several of the ions cause
inactivation of gK, a type of ionic gating that is not normally seen in squid
axon; i.e...
Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.
Tập 85 Số 2 - Trang 247-289 - 1985
Microprocessor-controlled changes of [free Ca2+] at the outer surface of the
sarcoplasmic reticulum (SR) wrapped around individual myofibrils of a skinned
canine cardiac Purkinje cell and aequorin bioluminescence recording were used to
study the mechanism of Ca2+-induced release of Ca2+ from the SR. This Ca2+
release is triggered by a rapid increase of [free Ca2+] at the outer surface of
the SR of...
The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve
Tập 58 Số 6 - Trang 599-619 - 1971
The relative permeability of sodium channels to 21 organic cations was studied
in myelinated nerve fibers. Ionic currents under voltage-clamp conditions were
measured in sodium-free solutions containing the test cation. The measured
reversal potential and the Goldman equation were used to calculate relative
permeabilities. The permeability sequence was: sodium ≈ hydroxylamine >
hydrazine > a...
A Physical Interpretation of the Phenomenological Coefficients of Membrane Permeability
Tập 45 Số 1 - Trang 143-179 - 1961
A "translation" of the phenomenological permeability coefficients into friction
and distribution coefficients amenable to physical interpretation is presented.
Expressions are obtained for the solute permeability coefficient ω and the
reflection coefficient σ for both non-electrolytic and electrolytic permeants.
An analysis of the coefficients is given for loose membranes as well as for
dense natu...