Journal of Gene Medicine
SCOPUS (1998-2023)SCIE-ISI
1099-498X
1521-2254
Mỹ
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
Genetics (clinical)Drug DiscoveryMolecular BiologyGeneticsMolecular Medicine
Các bài báo tiêu biểu
Gene therapy clinical trials worldwide to 2012 – an updateAbstract To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors....
Tập 15 Số 2 - Trang 65-77 - 2013
Side‐effects of a systemic injection of linear polyethylenimine–DNA complexesAbstract Background Systemic administration of linear polyethylenimine–DNA complexes (L‐PEI/DNA) results in transient expression of the transgene in the lung. This study analyzes the side‐effects associated with L‐PEI‐mediated transfection. Methods Mice weighing from 16 to...
Tập 4 Số 1 - Trang 84-91 - 2002
A model for non‐viral gene delivery: through syndecan adhesion molecules and powered by actinAbstract Background Cell transfection requires cationic DNA complexes and heparan sulfate proteoglycans (HSPGs) at the cell surface. Syndecans are transmembrane HSPGs that are ubiquitously expressed on adherent cells. Their polyanionic heparan sulfate moieties are bound at the distal end of their ectodomain, thus facilitating intera...
Tập 6 Số 7 - Trang 769-776 - 2004
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer
Tập 3 Số 2 - Trang 179-187 - 2001
Antibody targeted gene transfer to endotheliumAbstract Background One of the drawbacks of the currently available vectors for gene therapy is the lack of selectivity in gene delivery. We have therefore investigated a strategy to generate immunoliposomes to target non‐viral vectors to cell surface receptors on endothelium. Materials and m...
Tập 5 Số 4 - Trang 311-323 - 2003
Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9‐dependent maturation and IFN‐α productionAbstract Background Recombinant replication‐deficient adenoviral vectors (recAd) are attractive candidates for DNA vaccination approaches because they are able to activate the innate and adaptive immune systems. Here we explore the ability of recAd to transduce and activate subsets of dendritic cells, namely plasmacytoid dendritic c...
Tập 8 Số 11 - Trang 1300-1306 - 2006
Animal-free production of ccc-supercoiled plasmids for research and clinical applications
Tập 6 Số S1 - Trang S45-S53 - 2004
Intravenous glial‐derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoterAbstract Background Rats with experimental Parkinson's disease (PD) are treated with intravenous glial‐derived neurotrophic factor (GDNF) plasmid DNA, non‐viral gene therapy using Trojan horse liposomes (THLs) targeted with a monoclonal antibody (MAb) to the rat transferrin receptor (TfR). Expression of the transgene is confined to ...
Tập 10 Số 3 - Trang 306-315 - 2008
Improvement of transfection efficiency by using supercoiled plasmid DNA purified with arginine affinity chromatographyAbstract Background It is well known that the success of gene transfer to cells and subsequent expression is strictly affected by the vector manufacturing process. Several challenges encountered in the gene therapy field have emphasized the need for the development of novel platforms that allow the recovery of gene vectors and enabl...
Tập 11 Số 1 - Trang 79-88 - 2009