Journal of Gene Medicine

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Comparison of toxicity and transfection efficiency of amphiphilic block copolymers and polycationic polymers in striated muscles
Journal of Gene Medicine - Tập 11 Số 3 - Trang 240-249 - 2009
Caroline Roques, Elias Fattal, Yves Fromes
AbstractBackgroundGene delivery using synthetic vectors is frequently based on cationic compounds such as polyethyleneimine (PEI). However, few data have been published on the ability of PEI to mediate transgene expression in muscle tissue. Besides cationic vectors, there is increasing interest focusing on amphiphilic copolymers a...... hiện toàn bộ
Local tumour irradiation enhances the anti‐tumour effect of a double‐suicide gene therapy system in a murine glioma model
Journal of Gene Medicine - Tập 5 Số 5 - Trang 377-385 - 2003
Szilvia Désaknai, Katalin Lumniczky, Olga Ésik, Hirofumi Hamada, Géza Sáfrány
AbstractBackgroundGliomas are invasive malignant tumours with poor prognosis. Combination of gene directed enzyme pro‐drug therapy with existing treatment modalities might open new therapeutic potentials.MethodsMurine glioma 261 (Gl261) cells were transduced with an ad...... hiện toàn bộ
Effect of different parameters used for in vitro gene electrotransfer on gene expression efficiency, cell viability and visualization of plasmid DNA at the membrane level
Journal of Gene Medicine - Tập 15 Số 5 - Trang 169-181 - 2013
Saša Haberl, Maša Kandušer, Karel Flisar, Duša Hodžić, Vladimir B. Bregar, Damijan Miklavčič, Jean‐Michel Escoffre, Marie‐Pierre Rols, Mojca Pavlin
AbstractBackgroundGene electrotransfer is a nonviral method used for DNA delivery into cells. Several steps are involved. One of them is the interaction of DNA with the cell membrane, which is crucial before DNA can enter the cell. We analysed the level of DNA–membrane interaction in relation to electrotransfer efficiency and the ...... hiện toàn bộ
Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro
Journal of Gene Medicine - Tập 14 Số 1 - Trang 62-74 - 2012
Michelle Hunt, Dan Li, Michael P. Hay, Margaret J. Currie, Bridget Robinson, Adam V. Patterson, Gabi U. Dachs
AbstractBackgroundEnzyme prodrug gene therapy is designed as a targeted cancer treatment, destroying gene‐modified and bystander cells via exogenous enzyme‐generated cytotoxins. Targeting of tumour blood vessels using gene therapy is attractive, although optimal enzyme prodrug combinations have yet to be identified.... hiện toàn bộ
Associations between common genetic variants in microRNAs and Hirschsprung disease susceptibility in Southern Chinese children
Journal of Gene Medicine - Tập 23 Số 2 - 2021
Qi Wu, Jinglu Zhao, Yi Zheng, Xiaoli Xie, Qiuming He, Yun Zhu, Ning Wang, Lihua Huang, Li-Feng Lu, Tuqun Hu, Jixiao Zeng, Huimin Xia, Yan Zhang, Wei Zhong
AbstractIntroductionHirschsprung disease (HSCR), characterized by the defective migration of enteric neural crest cells, is a severe congenital tract disease in infants. Its etiology is not clear at present, although a genetic component plays an important role in its etiology. Many studies focused on the polymorphisms of microRNA ...... hiện toàn bộ
Animal-free production of ccc-supercoiled plasmids for research and clinical applications
Journal of Gene Medicine - Tập 6 Số S1 - Trang S45-S53 - 2004
Martin Schleef, Torsten Schmidt
Gene electro‐transfer improves transduction by modifying the fate of intramuscular DNA
Journal of Gene Medicine - Tập 5 Số 4 - Trang 324-332 - 2003
Manuela Cappelletti, Immacolata Zampaglione, Gabriella Rizzuto, Gennaro Ciliberto, Nicola La Monica, Elena Fattori
AbstractBackgroundIntramuscular gene delivery through injection of plasmid DNA has long been considered a promising approach for safe and simple in vivo gene expression for vaccination and gene therapy purposes. Recently, intramuscular gene delivery has been improved by applying low‐voltage electric puls...... hiện toàn bộ
Construction of X‐ray‐inducible promoters through cis‐acting element elongation and error‐prone polymerase chain reaction
Journal of Gene Medicine - Tập 10 Số 3 - Trang 316-324 - 2008
Ryohei Ogawa, Sung‐il Lee, Go Kagiya, Hisao Hirano, Satoshi Fukuda, Takashi Kondo, Tsutomu Kodaki
AbstractBackgroundA promoter that is activated by ionizing radiation may be a useful tool for cancer therapy since, with such a promoter, the therapeutic gene can be expressed only in cancer tissues by irradiation. An artificially constructed promoter is advantageous as natural promoters may have physiological limitations. However...... hiện toàn bộ
Production of helper‐dependent adenovirus vector relies on helper virus structure and complementing
Journal of Gene Medicine - Tập 4 Số 5 - Trang 498-509 - 2002
Huiyun Zhou, Tiejun Zhao, Xiao‐Mei Rao, Arthur L. Beaudet
AbstractBackgroundThe helper‐dependent (HD) adenoviral (Ad) vector relies on a helper virus to provide viral proteins for vector amplification. HD‐Ad vectors can significantly increase therapeutic gene expression and improve safety. However, the yield of an HD‐Ad vector is generally lower than that of an E1‐deleted first‐generatio...... hiện toàn bộ
Plasmid DNA purification
Journal of Gene Medicine - Tập 6 Số S1 - Trang S54-S66 - 2004
J. Stadler, Raf Lemmens, Tomas Nyhammar
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