Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts Tập 26 Số s1 - Trang 173-179 - 2011
Hartmut Jaeschke
AbstractLiver cell death induced by stresses such as ischemia‐reperfusion,
cholestasis and drug toxicity can trigger a sterile inflammatory response with
activation of innate immune cells through release of damage‐associated molecular
patterns (DAMPs). A similar inflammatory response can be induced by
pathogen‐associated molecular patterns (PAMPs) such as endotoxin. Both DAMPs and
PAMPs activate t... hiện toàn bộ
Epidemiological characteristics and risk factors of hepatocellular carcinoma Tập 12 Số 9-10 - 1997
Chien‐Jen Chen, Ming‐Whei Yu, Yun‐Fan Liaw
ABSTRACTHepatocellular carcinoma (HCC) is one of the major cancers in the world.
There is a striking variation in HCC incidence rates between various countries,
with a highest‐to‐lowest ratio of 112.5 for males and 54.7 for females. The
high‐risk populations are clustered in sub‐Saharan Africa and eastern Asia. The
male‐to‐female ratio for HCC ranges from < 1 to 6.4 and mostly from 2 to 4.
There e... hiện toàn bộ
The epidemiology of inflammatory bowel disease: East meets west Tập 35 Số 3 - Trang 380-389 - 2020
Joyce Wing Yan Mak, Mirabella Zhao, Siew C. Ng, Johan Burisch
AbstractThe incidence of inflammatory bowel diseases (IBD) in East has risen
over the past decade to become a global disease. The increasing number of
studies on the incidence and course of IBD in East has enabled us to explore
East versus West differences in the epidemiology of IBD which could enhance our
understanding of the heterogeneity of the disease and eventually assist in the
discovery of ... hiện toàn bộ
Non‐alcoholic steatohepatitis in type 2 diabetes mellitus Tập 19 Số 8 - Trang 854-858 - 2004
Parijat Gupte, Deepak Amarapurkar, Subhash Agal, Rajiv Baijal, PRAMOD KULSHRESTHA, SNEHANSU PRAMANIK, Hynek Pikhart, Aruna Madan, Anjali Amarapurkar, HAFEEZUNNISA
AbstractBackground and Aims: Non‐alcoholic steatohepatitis (NASH) is commonly
associated with type 2 diabetes mellitus (DM). Prevalence of NASH in type 2 DM
has not been well studied and there is an epidemic rise in type 2 DM in Asian
and Western populations. Its association with chronic liver disease in the form
of NASH makes it an important health problem. Hence we have studied its
prevalence a... hiện toàn bộ
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis Tập 22 Số s1 - 2007
Tatiana Kisseleva, David A. Brenner
AbstractLiver fibrosis is caused by many chronic diseases. Liver injury results
in activation of collagen‐producing cells and excessive deposition of
extracellular matrix proteins. This process is orchestrated by many cell types.
Hepatocytes apoptosis and inflammatory cells trigger secretion of profibrogenic
and proinflammatory cytokines, such as transforming growth factor‐β1,
angiotensin II, lept... hiện toàn bộ
Rapid hepatic fate specification of adipose‐derived stem cells and their therapeutic potential for liver failure Tập 24 Số 1 - Trang 70-77 - 2009
Agnieszka Banaś-Za̧bczyk, Takumi Teratani, Yusuke Yamamoto, Makoto Tokuhara, Fumitaka Takeshita, Mitsuhiko Osaki, Takashi Kato, Hitoshi Okochi, Takahiro Ochiya
AbstractBackground and Aim: Multipotential mesenchymal stem cells (MSC),
present in many organs and tissues, represent an attractive tool for the
establishment of a successful stem cell‐based therapy in the field of
regeneration medicine. Adipose tissue mesenchymal stem cells (AT‐MSC), known as
adipose‐derived stem cells (ASC) are especially attractive in the context of
future clinical applicatio... hiện toàn bộ
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis Tập 27 Số s2 - Trang 65-68 - 2012
Keiko Iwaisako, David A. Brenner, Tatiana Kisseleva
AbstractChronic liver injury of many etiologies produces liver fibrosis and may
eventually lead to the formation of cirrhosis. Fibrosis is part of a dynamic
process associated with the continuous deposition and resorption of
extracellular matrix, mainly fibrillar collagen. Studies of fibrogenesis
conducted in many organs including the liver demonstrate that the primary source
of the extracellular ... hiện toàn bộ