Journal of Experimental Medicine
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Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".
Journal of Experimental Medicine - Tập 179 Số 2 - Trang 609-618 - 1994
To determine whether T cells, like B cells, can become clonally expanded in
normal individuals as a function of age, we compared the T cell V beta
repertoire of cord blood to that of peripheral blood from normal donors over 65
yr of age. T cells from elderly subjects contained expanded subsets (greater
than the mean+three standard deviations) of T cell receptor (TCR) V beta
populations. These expa...
Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense
Journal of Experimental Medicine - Tập 200 Số 10 - Trang 1347-1358 - 2004
Peripheral T cell diversity is virtually constant in the young, but is
invariably reduced in aged mice and humans. CD8+ T cell clonal expansions (TCE)
are the most drastic manifestation of, and possible contributors to, this
reduced diversity. We show that the presence of TCE results in reduced CD8+, but
not CD4+, T cell diversity, and in functional inability to mobilize parts of the
CD8+ T cell r...
Resolvins suppress tumor growth and enhance cancer therapy
Journal of Experimental Medicine - Tập 215 Số 1 - Trang 115-140 - 2018
Cancer therapy reduces tumor burden by killing tumor cells, yet it
simultaneously creates tumor cell debris that may stimulate inflammation and
tumor growth. Thus, conventional cancer therapy is inherently a double-edged
sword. In this study, we show that tumor cells killed by chemotherapy or
targeted therapy (“tumor cell debris”) stimulate primary tumor growth when
coinjected with a subthreshold ...
THE CYTOLOGICAL DISTRIBUTION IN PIGEON SKELETAL MUSCLE OF ENZYMES ACTING ON PHOSPHORYLATED NUCLEOTIDES
Journal of Experimental Medicine - Tập 97 Số 4 - Trang 553-572 - 1953
A procedure has been described for the centrifugal fractionation of the
cytological components of pigeon breast muscle. An analysis of the distribution
of enzyme activity among the different particles reveals a predominant location
of magnesium-activated ATPase and myokinase in the cytochondria. The
myofibrillar nuclear components are the site of calcium-activated ATPase and
adenylic acid deaminas...
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
Journal of Experimental Medicine - Tập 160 Số 2 - Trang 521-540 - 1984
We studied the mechanism of lymphocytic choriomeningitis virus (LCMV)
persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in
BALB/c WEHI mice infected at birth with LCMV Armstrong strain. Using adoptive
transfer experiments we found that spleen cells from persistently infected
(carrier) mice actively suppressed the expected LCMV-specific CTL response of
spleen cells from norm...
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Journal of Experimental Medicine - Tập 214 Số 3 - Trang 579-596 - 2017
Pancreatic stellate cells (PSCs) differentiate into cancer-associated
fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease
progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA).
However, it is unknown whether CAFs uniformly carry out these tasks or if
subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF
subpopulation with e...
Chikungunya virus–induced autophagy delays caspase-dependent cell death
Journal of Experimental Medicine - Tập 209 Số 5 - Trang 1029-1047 - 2012
Autophagy is an important survival pathway and can participate in the host
response to infection. Studying Chikungunya virus (CHIKV), the causative agent
of a major epidemic in India, Southeast Asia, and southern Europe, we reveal a
novel mechanism by which autophagy limits cell death and mortality after
infection. We use biochemical studies and single cell multispectral assays to
demonstrate that...
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity
Journal of Experimental Medicine - Tập 214 Số 8 - Trang 2405-2420 - 2017
Mitochondrial dysfunction is the most prominent source of oxidative stress in
acute and chronic kidney disease. NLRX1 is a receptor of the innate immune
system that is ubiquitously expressed and localized in mitochondria. We
investigated whether NLRX1 may act at the interface of metabolism and innate
immunity in a model of oxidative stress. Using a chimeric mouse model for renal
ischemia-reperfusi...
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
Journal of Experimental Medicine - Tập 204 Số 12 - Trang 2935-2948 - 2007
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in
breast cancer. However, the reason that Jagged1 and/or Notch overexpression
portends a poor prognosis is unknown. We identify Slug, a transcriptional
repressor, as a novel Notch target and show that elevated levels of Slug
correlate with increased expression of Jagged1 in various human cancers. Slug
was essential for Not...
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
Journal of Experimental Medicine - Tập 206 Số 1 - Trang 15-23 - 2009
The endogenous cellular and molecular mechanisms that control acute inflammation
and its resolution are of wide interest. Using self-resolving inflammatory
exudates and lipidomics, we have identified a new pathway involving biosynthesis
of potent antiinflammatory and proresolving mediators from the essential fatty
acid docosahexaenoic acid (DHA) by macrophages (MΦs). During the resolution of
mouse...
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