Journal of Experimental Medicine

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Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".
Journal of Experimental Medicine - Tập 179 Số 2 - Trang 609-618 - 1994
David N. Posnett, Renu Saxena, Shara Kabak, C. Russo
To determine whether T cells, like B cells, can become clonally expanded in normal individuals as a function of age, we compared the T cell V beta repertoire of cord blood to that of peripheral blood from normal donors over 65 yr of age. T cells from elderly subjects contained expanded subsets (greater than the mean+three standard deviations) of T cell receptor (TCR) V beta populations. Th...... hiện toàn bộ
Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense
Journal of Experimental Medicine - Tập 200 Số 10 - Trang 1347-1358 - 2004
Ilhem Messaoudi, Joël LeMaoult, José A. Guevara-Patiño, Beatrix Metzner, Janko Nikolich‐Žugich
Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged mice and humans. CD8+ T cell clonal expansions (TCE) are the most drastic manifestation of, and possible contributors to, this reduced diversity. We show that the presence of TCE results in reduced CD8+, but not CD4+, T cell diversity, and in functional inability to mobilize parts of the CD8+ ...... hiện toàn bộ
Resolvins suppress tumor growth and enhance cancer therapy
Journal of Experimental Medicine - Tập 215 Số 1 - Trang 115-140 - 2018
Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang, Allison Gartung, Kristen Lehner, Diane R. Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R. Greene, Yael Gus‐Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P. Sukhatme, Arja Kaipainen, Mark W. Kieran, Sui Huang, Avi Schroeder
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy (“tumor cell debris”) stimulate primary tumor growth when coinjected with a subth...... hiện toàn bộ
THE CYTOLOGICAL DISTRIBUTION IN PIGEON SKELETAL MUSCLE OF ENZYMES ACTING ON PHOSPHORYLATED NUCLEOTIDES
Journal of Experimental Medicine - Tập 97 Số 4 - Trang 553-572 - 1953
Amara Kitiyakara, John W. Harman
A procedure has been described for the centrifugal fractionation of the cytological components of pigeon breast muscle. An analysis of the distribution of enzyme activity among the different particles reveals a predominant location of magnesium-activated ATPase and myokinase in the cytochondria. The myofibrillar nuclear components are the site of calcium-activated ATPase and adenylic acid ...... hiện toàn bộ
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
Journal of Experimental Medicine - Tập 160 Số 2 - Trang 521-540 - 1984
Rafi Ahmed, A. Salmi, L D Butler, Jacques M. Chiller, M B Oldstone
We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB/c WEHI mice infected at birth with LCMV Armstrong strain. Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV-specific CTL response of spleen cells f...... hiện toàn bộ
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Journal of Experimental Medicine - Tập 214 Số 3 - Trang 579-596 - 2017
Daniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, Ana S. Almeida, Mariano Ponz‐Sarvisé, Vincenzo Corbo, Tobiloba E. Oni, Stephen Hearn, Eun Jung Lee, Iok In Christine Chio, Chang‐Il Hwang, Hervé Tiriac, Lindsey A. Baker, Dannielle D. Engle, Christine Feig, Anne Kultti, Mikala Egeblad, Douglas T. Fearon, James M. Crawford, Hans Clevers, Youngkyu Park, David A. Tuveson
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF subpopulatio...... hiện toàn bộ
Chikungunya virus–induced autophagy delays caspase-dependent cell death
Journal of Experimental Medicine - Tập 209 Số 5 - Trang 1029-1047 - 2012
Pierre-Emmanuel Joubert, Scott Werneke, Claire de la Calle, Florence Guivel‐Benhassine, Alessandra Giodini, Lucie Peduto, Beth Levine, Olivier Schwartz, Deborah J. Lenschow, Matthew L. Albert
Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a major epidemic in India, Southeast Asia, and southern Europe, we reveal a novel mechanism by which autophagy limits cell death and mortality after infection. We use biochemical studies and single cell multispectral assays to demonstr...... hiện toàn bộ
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity
Journal of Experimental Medicine - Tập 214 Số 8 - Trang 2405-2420 - 2017
Geurt Stokman, Lotte Kors, Pieter J. Bakker, Elena Rampanelli, Nike Claessen, Gwendoline J.D. Teske, Loes M. Butter, Harmen van Andel, Marius A. van den Bergh Weerman, Per Larsen, Mark C. Dessing, Coert J. Zuurbier, Stephen E. Girardin, Sandrine Florquin, Jaklien C. Leemans
Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innate immunity in a model of oxidative stress. Using a chimeric mouse model for renal ischemia-r...... hiện toàn bộ
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
Journal of Experimental Medicine - Tập 204 Số 12 - Trang 2935-2948 - 2007
Kevin G. Leong, Kyle Niessen, Iva Kulic, Afshin Raouf, Connie J. Eaves, Ingrid L. Pollet, Aly Karsan
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor prognosis is unknown. We identify Slug, a transcriptional repressor, as a novel Notch target and show that elevated levels of Slug correlate with increased expression of Jagged1 in various human cancers. Slug was essential...... hiện toàn bộ
Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.
Journal of Experimental Medicine - Tập 171 Số 2 - Trang 377-387 - 1990
Federico Carbone, Michael J. Bevan
MHC class I-restricted T lymphocyte responses are usually directed to cellular antigenic components resulting from endogenous gene expression. Exogenous, non-replicating antigens, such as soluble proteins, usually fail to enter the class I pathway of antigen processing and presentation. Consistent with this notion, we have recently shown that soluble, exogenous proteins can be efficiently ...... hiện toàn bộ
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