Journal of Experimental Medicine

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Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense
Journal of Experimental Medicine - Tập 200 Số 10 - Trang 1347-1358 - 2004
Ilhem Messaoudi, Joël LeMaoult, José A. Guevara-Patiño, Beatrix Metzner, Janko Nikolich‐Žugich
Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged mice and humans. CD8+ T cell clonal expansions (TCE) are the most drastic manifestation of, and possible contributors to, this reduced diversity. We show that the presence of TCE results in reduced CD8+, but not CD4+, T cell diversity, and in functional inability to mobilize parts of the CD8+ ...... hiện toàn bộ
Resolvins suppress tumor growth and enhance cancer therapy
Journal of Experimental Medicine - Tập 215 Số 1 - Trang 115-140 - 2018
Megan L. Sulciner, Charles N. Serhan, Molly M. Gilligan, Dayna K. Mudge, Jaimie Chang, Allison Gartung, Kristen Lehner, Diane R. Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R. Greene, Yael Gus‐Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P. Sukhatme, Arja Kaipainen, Mark W. Kieran, Sui Huang, Avi Schroeder
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy (“tumor cell debris”) stimulate primary tumor growth when coinjected with a subth...... hiện toàn bộ
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
Journal of Experimental Medicine - Tập 160 Số 2 - Trang 521-540 - 1984
Rafi Ahmed, A. Salmi, L D Butler, Jacques M. Chiller, M B Oldstone
We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB/c WEHI mice infected at birth with LCMV Armstrong strain. Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV-specific CTL response of spleen cells f...... hiện toàn bộ
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
Journal of Experimental Medicine - Tập 206 Số 1 - Trang 15-23 - 2009
Charles N. Serhan, Yang Rong, Kimberly Martinod, Kie Kasuga, Padmini S. Pillai, Timothy F. Porter, Sungwhan F. Oh, Matthew Spite
The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by macrophages (MΦs). During the resolution ...... hiện toàn bộ
Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target.
Journal of Experimental Medicine - Tập 174 Số 2 - Trang 327-334 - 1991
Petter Höglund, Rickard Glas, Claes Öhlén, Hans‐Gustaf Ljunggren, Klas Kärre
The mechanism behind natural tumor resistance conveyed by a H-2Dd transgene to C57Bl/6 (B6) mice was investigated. Transgenic D8 mice were more efficient than control mice in natural killer (NK) cell mediated rapid elimination of intravenously inoculated radiolabeled lymphoma cells of B6 origin, such as RBL-5. There was no difference between D8 and B6 mice when elimination of YAC-1 targets...... hiện toàn bộ
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
Journal of Experimental Medicine - Tập 199 Số 12 - Trang 1631-1640 - 2004
Melissa B. Uccellini, Courtney Broughton, Fabienne Mackay, Shizuo Akira, Ann Marshak‐Rothstein, Ian R. Rifkin
Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chrom...... hiện toàn bộ
The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.
Journal of Experimental Medicine - Tập 148 Số 6 - Trang 1510-1522 - 1978
John W. Kappler, Philippa Marrack
We have studied the properties of helper T cells specific for sheep erythrocytes (SRBC), keyhole limpet hemocyanin (KLH), or poly-L-(Tyr,Glu)-poly-DL-Ala-poly-L-Lys [(T,G)-A--L]. These T cells differentiated and were primed in vivo in irradiation chimeras constructed of various combinations of F1 and parental bone marrow donors and irradiated recipients. Primed T cells were then tested for...... hiện toàn bộ
Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.
Journal of Experimental Medicine - Tập 151 Số 6 - Trang 1452-1467 - 1980
Dan L. Longo, R H Schwartz
The cellular requirements for immune response (Ir) gene expression in a T cell proliferative response under dual Ir gene control were examined with radiation-induced bone marrow chimeras. The response to poly(Glu55Lys36Phe9)n (GLphi) requires two responder alleles that in the [B10.A X B10.A(18R)]F1 map in I-Ab and I-Ek/Cd. Chimeras in which a mixture of the nonresponder B10.A parental cell...... hiện toàn bộ
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.
Journal of Experimental Medicine - Tập 173 Số 1 - Trang 159-166 - 1991
Edward J. Pearce, Patricia Caspar, Jean‐Marie Grzych, Fred A. Lewis, Alan Sher
In the mouse, infection with Schistosoma mansoni results in an egg-producing infection and associated disease, whereas vaccination with attenuated larval stages produces a substantial and specific immunity in the absence of egg-induced pathology. Preliminary data showing enhanced interleukin-5 (IL-5) production by T cells from infected mice and interferon gamma (IFN-gamma) synthesis by cel...... hiện toàn bộ
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
Journal of Experimental Medicine - Tập 208 Số 3 - Trang 577-592 - 2011
Li Wang, Rotem Rubinstein, J. Louise Lines, Anna Wasiuk, Cory L. Ahonen, Yanxia Guo, Li‐Fan Lu, David Gondek, Yan Wang, Roy A. Fava, András Fiser, S.C. Almo, Randolph J. Noelle
The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated V-domain Ig suppressor of T cell activation (VISTA). VISTA is primar...... hiện toàn bộ
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