NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

Allen, 2014, Non-inflammasome forming NLRs in inflammation and tumorigenesis, Front. Immunol., 5, 169, 10.3389/fimmu.2014.00169

Allen, 2011, NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways, Immunity., 34, 854, 10.1016/j.immuni.2011.03.026

Arnoult, 2009, An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix, J. Cell Sci., 122, 3161, 10.1242/jcs.051193

Bonventre, 2011, Cellular pathophysiology of ischemic acute kidney injury, J. Clin. Invest., 121, 4210, 10.1172/JCI45161

Devarajan, 2006, Update on mechanisms of ischemic acute kidney injury, J. Am. Soc. Nephrol., 17, 1503, 10.1681/ASN.2006010017

Duffield, 2006, Resolvin D series and protectin D1 mitigate acute kidney injury, J. Immunol., 177, 5902, 10.4049/jimmunol.177.9.5902

Everts, 2014, TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation, Nat. Immunol., 15, 323, 10.1038/ni.2833

Frezza, 2007, Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts, Nat. Protoc., 2, 287, 10.1038/nprot.2006.478

Imbeault, 2014, Nlrx1 regulates neuronal cell death, Mol. Brain., 7, 90, 10.1186/s13041-014-0090-x

Ishimoto, 2016, Mitochondria: a therapeutic target in acute kidney injury, Nephrol. Dial. Transplant., 31, 1062, 10.1093/ndt/gfv317

Iyer, 2009, Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome, Proc. Natl. Acad. Sci. USA., 106, 20388, 10.1073/pnas.0908698106

Jansen, 2017, Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps, Kidney Int., 91, 352, 10.1016/j.kint.2016.08.006

Kang, 2015, Suppression of NLRX1 in chronic obstructive pulmonary disease, J. Clin. Invest., 125, 2458, 10.1172/JCI71747

Knott, 2008, Mitochondrial fragmentation in neurodegeneration, Nat. Rev. Neurosci., 9, 505, 10.1038/nrn2417

Kopp, 1999, The Toll-receptor family and control of innate immunity, Curr. Opin. Immunol., 11, 13, 10.1016/S0952-7915(99)80003-X

Leemans, 2005, Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney, J. Clin. Invest., 115, 2894, 10.1172/JCI22832

Leemans, 2009, The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury, PLoS One., 4, e5704, 10.1371/journal.pone.0005704

Leemans, 2014, Pattern recognition receptors and the inflammasome in kidney disease, Nat. Rev. Nephrol., 10, 398, 10.1038/nrneph.2014.91

Li, 2017, NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury, J. Lipid Res., 58, 1080, 10.1194/jlr.M072587

Lu, 2015, Modeling-enabled characterization of novel NLRX1 ligands, PLoS One., 10, e0145420, 10.1371/journal.pone.0145420

Martinon, 2002, The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta, Mol. Cell., 10, 417, 10.1016/S1097-2765(02)00599-3

Menke, 2014, The effect of ischemia/reperfusion on the kidney graft, Curr. Opin. Organ Transplant., 19, 395, 10.1097/MOT.0000000000000090

Miyake, 2013, Mitochondrial complex III deficiency caused by a homozygous UQCRC2 mutation presenting with neonatal-onset recurrent metabolic decompensation, Hum. Mutat., 34, 446, 10.1002/humu.22257

Moore, 2008, NLRX1 is a regulator of mitochondrial antiviral immunity, Nature., 451, 573, 10.1038/nature06501

Ott, 2007, Mitochondria, oxidative stress and cell death, Apoptosis., 12, 913, 10.1007/s10495-007-0756-2

Pulskens, 2008, Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury, PLoS One., 3, e3596, 10.1371/journal.pone.0003596

Pulskens, 2010, TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury, J. Am. Soc. Nephrol., 21, 1299, 10.1681/ASN.2009070722

Quirós, 2015, New roles for mitochondrial proteases in health, ageing and disease, Nat. Rev. Mol. Cell Biol., 16, 345, 10.1038/nrm3984

Rebsamen, 2011, NLRX1/NOD5 deficiency does not affect MAVS signalling, Cell Death Differ., 18, 1387, 10.1038/cdd.2011.64

Singh, 2015, NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells, Biochim. Biophys. Acta., 1853, 1073, 10.1016/j.bbamcr.2015.01.016

Soares, 2013, NLRX1 does not inhibit MAVS-dependent antiviral signalling, Innate Immun., 19, 438, 10.1177/1753425912467383

Soares, 2014, The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis, J. Biol. Chem., 289, 19317, 10.1074/jbc.M114.550111

Stokman, 2010, Stem cell factor expression after renal ischemia promotes tubular epithelial survival, PLoS One., 5, e14386, 10.1371/journal.pone.0014386

Stokman, 2011, Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure, J. Am. Soc. Nephrol., 22, 859, 10.1681/ASN.2010040423

Stokman, 2014, Epac-Rap signaling reduces oxidative stress in the tubular epithelium, J. Am. Soc. Nephrol., 25, 1474, 10.1681/ASN.2013070679

Susantitaphong, 2013, World incidence of AKI: a meta-analysis, Clin. J. Am. Soc. Nephrol., 8, 1482, 10.2215/CJN.00710113

Wang, 2011, The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation, Immunity., 35, 871, 10.1016/j.immuni.2011.09.021

Xia, 2011, NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK, Immunity., 34, 843, 10.1016/j.immuni.2011.02.022

Zuurbier, 2005, Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution, Am. J. Physiol. Heart Circ. Physiol., 289, H496, 10.1152/ajpheart.01182.2004