The role of corticotropin-releasing factor in depression and anxiety disorders Tập 160 Số 1 - Trang 1-12 - 1999
Lotta Arborelius, M J Owens, PM Plotsky, Charles B. Nemeroff
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the ev...... hiện toàn bộ Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor Tập 209 Số 2 - Trang 139-151 - 2011
Soo‐Hyun Kim, Jeremy E. Turnbull, Scott E. Guimond
Extracellular matrices (ECM) are secreted molecules that constitute the cell microenvironment, composed of a dynamic and complex array of glycoproteins, collagens, glycosaminoglycans and proteoglycans. ECM provides the bulk, shape and strength of many tissues in vivo, such as basement membrane, bone and cartilage. In vitro, most animal ...... hiện toàn bộ Adipocytokines in obesity and metabolic disease Tập 220 Số 2 - Trang T47-T59 - 2014
Haiming Cao
The current global obesity pandemic is the leading cause for the soaring rates of metabolic diseases, especially diabetes, cardiovascular disease, hypertension, and non-alcoholic hepatosteatosis. Efforts devoted to find cures for obesity and associated disorders in the past two decades have prompted intensive interest in adipocyte biology, and have led to major advances in the mechanistic ...... hiện toàn bộ Estrogen increases in vivo leptin production in rats and human subjects Tập 154 Số 2 - Trang 285-292 - 1997
Hiroyuki Shimizu, Yoshiharu Shimomura, Yoshihito Nakanishi, T Futawatari, K Ohtani, N. Sato, Masataka Mori
Abstract
The decrease in estrogen in menopausal women increases body fat. The present studies were undertaken to investigate the involvement of estrogen in leptin production in vivo. In the first study, expression of ob gene mRNA in white adipose tissue was measured at 2 and 8 weeks after ovariectomy in ...... hiện toàn bộ Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system Tập 216 Số 2 - Trang R1-R17 - 2013
Robson A.S. Santos, Anderson J. Ferreira, Thiago Verano‐Braga, Michael Bäder
Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS because it exerts a vast array of actions, many of them opposite to those attributed to the main effector peptide of the RAS, Ang II. The discovery of the Ang-converting enzyme (ACE) homolog ACE2 brought to light an importan...... hiện toàn bộ Development of a microtitre plate enzyme immunoassay for the determination of progesterone Tập 101 Số 1 - Trang 41-49 - 1984
Coralie Munro, G. H. Stabenfeldt
ABSTRACT
A rapid, solid-phase microtitre plate enzyme immunoassay (EIA) for progesterone is described using progesterone 3-O-carboxymethyloxime–horseradish peroxidase as the label and an antiserum raised in rabbits to a progesterone 11α-hemisuccinyl–bovine serum albumin immunogen. A competitive reaction was used with a reaction time of 2 h. Antibody-bound a...... hiện toàn bộ Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells Tập 195 Số 1 - Trang 125-131 - 2007
Tijana Krajisnik, Peyman Björklund, Richard Marsell, Östen Ljunggren, Göran Åkerström, Kenneth B. Jonsson, Gunnar Westin, Tobias E. Larsson
Fibroblast growth factor-23 (FGF23) is a circulating factor that decreases serum levels of inorganic phosphate (Pi) as well as 1,25-dihydroxyvitamin D3. Recent studies also suggest a correlation between serum levels of FGF23 and parathyroid hormone (PTH) in patients with chronic kidney disease. It is, however, unknown whether FGF23 directly modulates PTH expression, or...... hiện toàn bộ The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification Tập 211 Số 2 - Trang 109-121 - 2011
Eleanor J. Mackie, Liliana Tatarczuch, Michiko Mirams
Endochondral ossification is the process that results in both the replacement of the embryonic cartilaginous skeleton during organogenesis and the growth of long bones until adult height is achieved. Chondrocytes play a central role in this process, contributing to longitudinal growth through a combination of proliferation, extracellular matrix (ECM) secretion and hypertrophy. Terminally d...... hiện toàn bộ