Journal of Endocrinology
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KINETIC STUDIES ON THE BIOSYNTHESIS OF CORTICOSTEROIDS IN VITRO FROM EXOGENOUS PRECURSORS BY THE INTERRENAL GLANDS OF THE NORMAL, CORTICOTROPHIN-TREATED AND ADENOHYPOPHYSECTOMIZED XENOPUS LAEVIS DAUDIN
Journal of Endocrinology - Tập 47 Số 2 - Trang 183-195 - 1970
SUMMARY Incubation of the adrenocortical tissue of Xenopus with labelled
steroidal precursors gave aldosterone, corticosterone, 11-deoxycorticosterone
and 18-hydroxycorticosterone as the major products. Kinetic studies indicated
that the major biosynthetic pathway in Xenopus is the same as that in the duck,
cobra and frog, and follows the sequence: pregnenolone → progesterone →
11-deoxycorticoster...
Suppression of lactation and acceleration of involution in the bovine mammary gland by a selective serotonin reuptake inhibitor
Journal of Endocrinology - Tập 209 Số 1 - Trang 45-54 - 2011
Serotonin (5-HT) is a homeostatic regulator of lactation. Selective 5-HT
reuptake inhibitors (SSRI) are commonly prescribed pharmaceuticals that inhibit
activity of the 5-HT reuptake transporter, increasing cellular exposure to 5-HT.
Use of SSRIs has been shown to alter lactation performance in humans and 5-HT
has been shown to reduce milk yield in cattle. However, it has not been
determined how S...
Oestradiol and somatomedin-C influence body weight patterns in premenarchial rhesus monkeys housed outdoors
Journal of Endocrinology - Tập 102 Số 3 - Trang 311-317 - 1984
ABSTRACT The influence of gonadal status on the pattern of changes in body
weight was examined in three groups of outdoor-housed premenarchial rhesus
monkeys (Macaca mulatta) from 1 to 2 years of age. Gonadally intact (n=8) and
ovariectomized oestradiol-treated females (n=5) gained significantly more weight
than ovariectomized untreated females (n=5). The overall larger weight gains for
the intact...
Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretion
Journal of Endocrinology - Tập 121 Số 3 - Trang 521-536 - 1989
ABSTRACT Oxytocin secretion is inhibited by opioids, and oxytocin is important
in parturition. The effects on parturition of morphine, a relatively selective
μ-opioid receptor agonist, were studied in the rat. Morphine or vehicle with or
without the opiate antagonist naloxone were administered immediately after the
birth of the second pup and the subsequent course of parturition was recorded in
a ...
Sex differences in hepatic cytochrome P-450 monooxygenase activities in rainbow trout during an annual reproductive cycle
Journal of Endocrinology - Tập 124 Số 2 - Trang 207-213 - 1990
ABSTRACT Hepatic microsomal cytochrome P-450 monooxygenase activities were
investigated in rainbow trout during an annual reproductive cycle. The fish were
kept in tanks supplied with fresh water at a constant temperature of 10 °C. The
daily light and darkness cycle was adjusted to follow the natural photoperiod.
Sampling was performed once every month for 1 year. Higher
benzo(a)pyrene-hydroxylase...
Steroidogenesis during postnatal development in the mouse ovary
Journal of Endocrinology - Tập 130 Số 1 - Trang 101-NP - 1991
ABSTRACT In the mouse, follicular formation and development is largely
postnatal. Changes in ovarian steroidogenesis during early postnatal life are
likely, therefore, to reflect changes in follicular activity during early
folliculogenesis. In this study, basal progesterone and androstenedione
production and responsiveness to gonadotrophins, dibutyryl cyclic AMP (dbcAMP)
and 22R-hydroxycholesterol...
Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse
Journal of Endocrinology - Tập 135 Số 3 - Trang 517-NP - 1992
ABSTRACT The hypogonadal (hpg) mouse has a congenital deficiency in
gonadotrophin-releasing hormone and the gonads consequently lack exposure to
endogenous gonadotrophins during development. To determine the effect of FSH on
Leydig cell function in these animals adult hpg mice were injected twice daily
with FSH (2 μg injections) or LH (40 ng injections, the presumed LH
contamination of FSH used). ...
Effect of high-density lipoprotein on bovine granulosa cells: progesterone production in newly isolated cells and during cell culture
Journal of Endocrinology - Tập 124 Số 2 - Trang 255-260 - 1990
ABSTRACT It has been proposed that changes in steroidogenesis which occur during
early development of the corpus luteum may be due to increased availability of
lipoproteins. Bovine follicular fluid, however, contains significant amounts of
high-density lipoprotein (HDL), and granulosa cells are exposed to this
lipoprotein before ovulation. To determine whether bovine granulosa cells can
utilize HD...
Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia
Journal of Endocrinology - Tập 178 Số 1 - Trang 19-27 - 2003
Glucocorticoid (GC) resistance is a phenomenon of major significance in a number
of clinical situations, including the therapy of lymphoid malignancies.
Resistance may concern all, or just selected, GC effects, it may be absolute or
just reflect a state of reduced sensitivity and, clinically relevant, be
reversible or irreversible. Numerous molecular mechanisms can be envisaged
acting either 'upst...
THE EFFECT OF REMOVAL OF THE OLFACTORY BULBS ON THE GONADS OF MICE
Journal of Endocrinology - Tập 14 Số 2 - Trang 160-163 - 1956
SUMMARY 1. The ovaries and uteri of mature female mice rendered anosmic by
removal of the olfactory bulbs were significantly smaller than those of control
animals. Corpora lutea were absent or atrophic, and the vagina was closed in
most of these animals. 2. No effect on the testes of anosmic males was observed.
The accessory glands were lighter and contained less secretion, but the
epithelium appe...
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