Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretionJournal of Endocrinology - Tập 121 Số 3 - Trang 521-536 - 1989
John A. Russell, R. G. Gosden, Elizabeth M. Humphreys, Reginald A. Cutting, N. Fitzsimons, Vicki Johnston, S. Liddle, Steven Gates Scott, J. Anne Stirland
ABSTRACT
Oxytocin secretion is inhibited by opioids, and oxytocin is important in parturition. The effects on parturition of morphine, a relatively selective μ-opioid receptor agonist, were studied in the rat. Morphine or vehicle with or without the opiate antagonist naloxone were administered immediately after the birth of the second pup and the subsequent...... hiện toàn bộ
Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytesJournal of Endocrinology - Tập 176 Số 3 - Trang 331-337 - 2003
Dionisios Chrysis, E. Martin Ritzén, Lars Sävendahl
Glucocorticoids cause significant growth retardation in mammals and humans and decreased proliferation of chondrocytes has been considered as the main local mechanism. Death by apoptosis is an important regulator of homeostasis in multicellular organisms. Here we chose to study the role of apoptosis in growth retardation caused by glucocorticoid treatment. We treated 7-week-old male rats w...... hiện toàn bộ
The uterine growth-promoting action of epidermal growth factor and its function in the fertility of miceJournal of Endocrinology - Tập 138 Số 3 - Trang 437-NP - 1993
Osamu Tsutsumi, Yuji Taketani, Takami Oka
ABSTRACT
Epidermal growth factor (EGF) levels in the submandibular glands and plasma are increased in pregnant and aged female mice. The possible role of EGF in fertility was studied in virgin and pregnant mice ranging in age from 10 to 90 weeks of age, employing sialoadenectomy, administration of EGF antibody and EGF replacement. The uterine weight in preg...... hiện toàn bộ
Influence of epidermal growth factor on liver regeneration after partial hepatectomy in miceJournal of Endocrinology - Tập 128 Số 3 - Trang 425-431 - 1991
Shinzaburo Noguchi, Y. Ohba, Takami Oka
ABSTRACT
The role of epidermal growth factor (EGF) in liver regeneration was studied in mice after partial hepatectomy. Two weeks before partial hepatectomy, mice were sham-operated (control) or sialoadenectomized (removal of submandibular glands) to reduce plasma EGF levels. Sialoadenectomized mice showed low plasma EGF levels (29·7 ±6·6 pmol/l; mean ± ... hiện toàn bộ
The role of corticotropin-releasing factor in depression and anxiety disordersJournal of Endocrinology - Tập 160 Số 1 - Trang 1-12 - 1999
Lotta Arborelius, M J Owens, PM Plotsky, Charles B. Nemeroff
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the ev...... hiện toàn bộ
MEASUREMENT OF FREE AND OCCUPIED CYTOPLASMIC AND NUCLEAR ANDROGEN RECEPTOR SITES IN RAT VENTRAL PROSTATE GLANDJournal of Endocrinology - Tập 74 Số 3 - Trang 393-404 - 1977
Peter J. Davies, Philip Thomas, K. Griffiths
SUMMARY
A method has been developed which allows the estimation of occupied and unoccupied androgen receptor sites in both cytoplasmic and nuclear fractions of rat ventral prostate. The procedure involves precipitation of receptor proteins and incubation of precipitates with labelled 5α-dihydrotestosterone. Uptake of 3H-labelled steroid...... hiện toàn bộ
IKKβ and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytesJournal of Endocrinology - Tập 201 Số 1 - Trang 75-80 - 2009
AnneMarie Gagnon, Anne Landry, Alexander Sorisky
To clarify how anti-adipogenic factors act on preadipocytes to inhibit their differentiation, we compared preadipocyte signaling responses generated by platelet-derived growth factor (PDGF; anti-adipogenic) versus insulin (pro-adipogenic). PDGF, but not insulin, stimulated the phosphorylation of inhibitor of κB kinase β (IKKβ) in a time-dependent manner. This PDGF-dependent phosphorylation...... hiện toàn bộ