Journal of Endocrinology

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KINETIC STUDIES ON THE BIOSYNTHESIS OF CORTICOSTEROIDS IN VITRO FROM EXOGENOUS PRECURSORS BY THE INTERRENAL GLANDS OF THE NORMAL, CORTICOTROPHIN-TREATED AND ADENOHYPOPHYSECTOMIZED XENOPUS LAEVIS DAUDIN
Journal of Endocrinology - Tập 47 Số 2 - Trang 183-195 - 1970
Siu‐Hong Chan, B. R. Edwards
SUMMARY Incubation of the adrenocortical tissue of Xenopus with labelled steroidal precursors gave aldosterone, corticosterone, 11-deoxycorticosterone and 18-hydroxycorticosterone as the major products. Kinetic studies indicated that the major biosynthetic pathway in Xenopus is the same as that in the du...... hiện toàn bộ
Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretion
Journal of Endocrinology - Tập 121 Số 3 - Trang 521-536 - 1989
John A. Russell, R. G. Gosden, Elizabeth M. Humphreys, Reginald A. Cutting, N. Fitzsimons, Vicki Johnston, S. Liddle, Steven Gates Scott, J. Anne Stirland
ABSTRACT Oxytocin secretion is inhibited by opioids, and oxytocin is important in parturition. The effects on parturition of morphine, a relatively selective μ-opioid receptor agonist, were studied in the rat. Morphine or vehicle with or without the opiate antagonist naloxone were administered immediately after the birth of the second pup and the subsequent...... hiện toàn bộ
Effect of high-density lipoprotein on bovine granulosa cells: progesterone production in newly isolated cells and during cell culture
Journal of Endocrinology - Tập 124 Số 2 - Trang 255-260 - 1990
P.J. O'Shaughnessy, Simon H. S. Pearce, MA Mannan
ABSTRACT It has been proposed that changes in steroidogenesis which occur during early development of the corpus luteum may be due to increased availability of lipoproteins. Bovine follicular fluid, however, contains significant amounts of high-density lipoprotein (HDL), and granulosa cells are exposed to this lipoprotein before ovulation. To determine whet...... hiện toàn bộ
Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes
Journal of Endocrinology - Tập 176 Số 3 - Trang 331-337 - 2003
Dionisios Chrysis, E. Martin Ritzén, Lars Sävendahl
Glucocorticoids cause significant growth retardation in mammals and humans and decreased proliferation of chondrocytes has been considered as the main local mechanism. Death by apoptosis is an important regulator of homeostasis in multicellular organisms. Here we chose to study the role of apoptosis in growth retardation caused by glucocorticoid treatment. We treated 7-week-old male rats w...... hiện toàn bộ
The uterine growth-promoting action of epidermal growth factor and its function in the fertility of mice
Journal of Endocrinology - Tập 138 Số 3 - Trang 437-NP - 1993
Osamu Tsutsumi, Yuji Taketani, Takami Oka
ABSTRACT Epidermal growth factor (EGF) levels in the submandibular glands and plasma are increased in pregnant and aged female mice. The possible role of EGF in fertility was studied in virgin and pregnant mice ranging in age from 10 to 90 weeks of age, employing sialoadenectomy, administration of EGF antibody and EGF replacement. The uterine weight in preg...... hiện toàn bộ
Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice
Journal of Endocrinology - Tập 128 Số 3 - Trang 425-431 - 1991
Shinzaburo Noguchi, Y. Ohba, Takami Oka
ABSTRACT The role of epidermal growth factor (EGF) in liver regeneration was studied in mice after partial hepatectomy. Two weeks before partial hepatectomy, mice were sham-operated (control) or sialoadenectomized (removal of submandibular glands) to reduce plasma EGF levels. Sialoadenectomized mice showed low plasma EGF levels (29·7 ±6·6 pmol/l; mean ± ... hiện toàn bộ
The role of corticotropin-releasing factor in depression and anxiety disorders
Journal of Endocrinology - Tập 160 Số 1 - Trang 1-12 - 1999
Lotta Arborelius, M J Owens, PM Plotsky, Charles B. Nemeroff
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the ev...... hiện toàn bộ
MEASUREMENT OF FREE AND OCCUPIED CYTOPLASMIC AND NUCLEAR ANDROGEN RECEPTOR SITES IN RAT VENTRAL PROSTATE GLAND
Journal of Endocrinology - Tập 74 Số 3 - Trang 393-404 - 1977
Peter J. Davies, Philip Thomas, K. Griffiths
SUMMARY A method has been developed which allows the estimation of occupied and unoccupied androgen receptor sites in both cytoplasmic and nuclear fractions of rat ventral prostate. The procedure involves precipitation of receptor proteins and incubation of precipitates with labelled 5α-dihydrotestosterone. Uptake of 3H-labelled steroid...... hiện toàn bộ
IKKβ and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytes
Journal of Endocrinology - Tập 201 Số 1 - Trang 75-80 - 2009
AnneMarie Gagnon, Anne Landry, Alexander Sorisky
To clarify how anti-adipogenic factors act on preadipocytes to inhibit their differentiation, we compared preadipocyte signaling responses generated by platelet-derived growth factor (PDGF; anti-adipogenic) versus insulin (pro-adipogenic). PDGF, but not insulin, stimulated the phosphorylation of inhibitor of κB kinase β (IKKβ) in a time-dependent manner. This PDGF-dependent phosphorylation...... hiện toàn bộ
HORMONAL EFFECTS IN VITRO ON RIBONUCLEIC ACID POLYMERASE IN NUCLEI ISOLATED FROM HUMAN PROSTATIC TISSUE
Journal of Endocrinology - Tập 59 Số 2 - Trang 367-368 - 1973
Peter J. Davies, K. Griffiths
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