Journal of Endocrinology

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The effect of social stress on adrenal axis activity in horses: the importance of monitoring corticosteroid-binding globulin capacity
Journal of Endocrinology - Tập 157 Số 3 - Trang 425-432 - 1998
Susan L. Alexander, CH Irvine
Plasma cortisol is largely bound to corticosteroid-binding globulin (CBG), which regulates its bioavailability by restricting exit from capillaries. Levels of CBG may be altered by several factors including stress and this can influence the amount of cortisol reaching cells. This study investigated the effect of social instability on plasma concentrations of CBG, total and free (not protei...... hiện toàn bộ
SUPPRESSION OF THE DEVELOPMENT OF FEMALE HAMSTER BEHAVIOUR BY IMPLANTS OF TESTOSTERONE AND NON-AROMATIZABLE ANDROGENS ADMINISTERED NEONATALLY
Journal of Endocrinology - Tập 67 Số 3 - Trang 439-445 - 1975
Arnold A. Gerall, MARCIA M. McMURRAY, Alice Farrell
SUMMARY Testosterone in its free form, and dihydrotestosterone (DHT) and androsterone, both androgens which are not aromatizable to oestrogen, injected in oil during the neonatal period have been reported not to modify the development of female sexual behaviour. This failure might be due to the short period of activity of these substances when injected in l...... hiện toàn bộ
EFFECTS OF ANTI-OESTROGEN TREATMENT OF NEONATAL MALE RATS ON LORDOSIS BEHAVIOUR AND MOUNTING BEHAVIOUR IN THE ADULT
Journal of Endocrinology - Tập 76 Số 2 - Trang 241-249 - 1978
P. Södersten
Male rats were treated daily with 100 μg of the anti-oestrogen ethamoxytriphetol (MER-25) or oil during the first 10 days of life and tested for lordosis behaviour and mounting behaviour as intact adults, after castration and after castration and oestradiol benzoate or testosterone propionate treatment. The MER-25-treated rats showed higher levels of lordosis behaviour than oil-treated rat...... hiện toàn bộ
INHIBITION, BY THE ANTI-OESTROGEN MER-25, OF DEFEMINIZATION INDUCED BY THE SYNTHETIC OESTROGEN RU 2858
Journal of Endocrinology - Tập 67 Số 3 - Trang 459-460 - 1975
Cynthia Doughty, JANET E. BOOTH, Paul G. McDonald, R.F. Parrott
Metabolic clearance of insulin-like growth factor-II in sheep
Journal of Endocrinology - Tập 123 Số 3 - Trang 461-468 - 1989
S. Hodgkinson, Susan R. Davis, L. G. Moore, H. V. Henderson, P. D. Gluckman
ABSTRACT The metabolic clearance of ovine insulin-like growth factor-II (IGF-II) was examined in sheep using 131I-labelled IGF-II. Following i.v. administration the tracer was distributed in a volume similar to that of the vascular space (58-5 ±3.3 ml/kg; mean ± s.e.m., n = 5) and demonstrat...... hiện toàn bộ
STUDIES WITH FRAGMENTS OF A HIGHLY ACTIVE ANALOGUE OF LUTEINIZING HORMONE RELEASING HORMONE
Journal of Endocrinology - Tập 81 Số 2 - Trang 175-182 - 1979
J. Sandow, W. König
The minimal structural requirements for gonadotrophin releasing activity were studied with fragments of a highly active analogue of luteinizing hormone releasing hormone (LH-RH), [d-Ser(But)6]LH-RH(1–9)nonapeptide-ethylamide (Hoe 766). All fragments are related to the C-terminal structure of LH-RH and have increased enzyme stabil...... hiện toàn bộ
Gain-of-function β-catenin in the uterine mesenchyme leads to impaired implantation and decidualization
Journal of Endocrinology - Tập 233 Số 1 - Trang 119-130 - 2017
Amanda L. Patterson, Jamieson Pirochta, Stephanie Y Tufano, Jose M. Teixeira
Embryo implantation and endometrial decidualization are critical events that occur during early pregnancy in humans and mice, and perturbation in either can result in infertility. WNT signaling through the canonical β-catenin pathway plays a pivotal role in embryonic Müllerian duct development, postnatal uterine maturation and establishment of pregnancy. Loss of β-catenin in the Müllerian ...... hiện toàn bộ
WINGLESS (WNT) signaling is a progesterone target for rat uterine stromal cell proliferation
Journal of Endocrinology - Tập 229 Số 2 - Trang 197-207 - 2016
Virginia Rider, Alex Talbott, Anuradha Bhusri, Zach Krumsick, Sierra Foster, Joshua Wormington, Bruce F. Kimler
Preparation of mammalian uterus for embryo implantation requires a precise sequence of cell proliferation. In rodent uterus, estradiol stimulates proliferation of epithelial cells. Progesterone operates as a molecular switch and redirects proliferation to the stroma by down-regulating glycogen synthase kinase-3β (GSK-3β) and stimulating β-catenin accumulation in the periluminal stromal cel...... hiện toàn bộ
Oxidative and nitrosative stress in brain mitochondria of diabetic rats
Journal of Endocrinology - Tập 187 Số 1 - Trang 37-44 - 2005
Raffaella Mastrocola, Francesca Restivo, Ilenia Vercellinatto, Oliviero Danni, Enrico Brignardello, Manuela Aragno, G Boccuzzi
Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical and structural abnormalities, may involve direct neuronal damage caused by intracellular glucose. The study assesses the direct effect of chronic hyperglycemia on the function of brain mitochondria, the major site of reactive species production, in diabetic streptozotocin (STZ) rats. Oxidative stress p...... hiện toàn bộ
Suppression of lactation and acceleration of involution in the bovine mammary gland by a selective serotonin reuptake inhibitor
Journal of Endocrinology - Tập 209 Số 1 - Trang 45-54 - 2011
Laura L. Hernandez, J.L. Collier, Archie J. Vomachka, R. John Collier, Nelson D. Horseman
Serotonin (5-HT) is a homeostatic regulator of lactation. Selective 5-HT reuptake inhibitors (SSRI) are commonly prescribed pharmaceuticals that inhibit activity of the 5-HT reuptake transporter, increasing cellular exposure to 5-HT. Use of SSRIs has been shown to alter lactation performance in humans and 5-HT has been shown to reduce milk yield in cattle. However, it has not been determin...... hiện toàn bộ
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