Suppression of lactation and acceleration of involution in the bovine mammary gland by a selective serotonin reuptake inhibitorJournal of Endocrinology - Tập 209 Số 1 - Trang 45-54 - 2011
Laura L. Hernandez, J.L. Collier, Archie J. Vomachka, R. John Collier, Nelson D. Horseman
Serotonin (5-HT) is a homeostatic regulator of lactation. Selective 5-HT reuptake inhibitors (SSRI) are commonly prescribed pharmaceuticals that inhibit activity of the 5-HT reuptake transporter, increasing cellular exposure to 5-HT. Use of SSRIs has been shown to alter lactation performance in humans and 5-HT has been shown to reduce milk yield in cattle. However, it has not been determin...... hiện toàn bộ
Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretionJournal of Endocrinology - Tập 121 Số 3 - Trang 521-536 - 1989
John A. Russell, R. G. Gosden, Elizabeth M. Humphreys, Reginald A. Cutting, N. Fitzsimons, Vicki Johnston, S. Liddle, Steven Gates Scott, J. Anne Stirland
ABSTRACT
Oxytocin secretion is inhibited by opioids, and oxytocin is important in parturition. The effects on parturition of morphine, a relatively selective μ-opioid receptor agonist, were studied in the rat. Morphine or vehicle with or without the opiate antagonist naloxone were administered immediately after the birth of the second pup and the subsequent...... hiện toàn bộ
Steroidogenesis during postnatal development in the mouse ovaryJournal of Endocrinology - Tập 130 Số 1 - Trang 101-NP - 1991
MA Mannan, P. O'Shaughnessy
ABSTRACT
In the mouse, follicular formation and development is largely postnatal. Changes in ovarian steroidogenesis during early postnatal life are likely, therefore, to reflect changes in follicular activity during early folliculogenesis. In this study, basal progesterone and androstenedione production and responsiveness to gonadotrophins, dibutyryl cycli...... hiện toàn bộ
Effects of FSH on Leydig cell morphology and function in the hypogonadal mouseJournal of Endocrinology - Tập 135 Số 3 - Trang 517-NP - 1992
P. O'Shaughnessy, MK Bennett, Ian Scott, H. M. Charlton
ABSTRACT
The hypogonadal (hpg) mouse has a congenital deficiency in gonadotrophin-releasing hormone and the gonads consequently lack exposure to endogenous gonadotrophins during development. To determine the effect of FSH on Leydig cell function in these animals adult hpg mice were injected twice daily w...... hiện toàn bộ
Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemiaJournal of Endocrinology - Tập 178 Số 1 - Trang 19-27 - 2003
Reinhard Kofler, Stefan Schmidt, Anita Kofler, Michael J. Ausserlechner
Glucocorticoid (GC) resistance is a phenomenon of major significance in a number of clinical situations, including the therapy of lymphoid malignancies. Resistance may concern all, or just selected, GC effects, it may be absolute or just reflect a state of reduced sensitivity and, clinically relevant, be reversible or irreversible. Numerous molecular mechanisms can be envisaged acting eith...... hiện toàn bộ
THE EFFECT OF REMOVAL OF THE OLFACTORY BULBS ON THE GONADS OF MICEJournal of Endocrinology - Tập 14 Số 2 - Trang 160-163 - 1956
W. K. Whitten
SUMMARY
1. The ovaries and uteri of mature female mice rendered anosmic by removal of the olfactory bulbs were significantly smaller than those of control animals. Corpora lutea were absent or atrophic, and the vagina was closed in most of these animals.
2. No effect on the testes of anosmic males was observed. The accessory glands ...... hiện toàn bộ