High resolution microarray comparative genomic hybridisation analysis using spotted oligonucleotidesJournal of Clinical Pathology - Tập 57 Số 6 - Trang 644-646 - 2004
Beatriz Carvalho, E Ouwerkerk, Gerrit A. Meijer, Bauke Ylstra
Background:Currently, comparative genomic hybridisation array (array CGH) is the method of choice for studying genome wide DNA copy number changes. To date, either amplified representations of bacterial artificial chromosomes (BACs)/phage artificial chromosomes (PACs) or cDNAs have been spotted as probes. The production of BAC/PAC and cDNA arrays is time consuming an...... hiện toàn bộ
Gene of the month:DICER1:ruler and controllerJournal of Clinical Pathology - Tập 74 Số 2 - Trang 69-72 - 2021
Michelle Thunders, Brett Delahunt
DICER1 is a highly conserved RNaseIII endoribonuclease that has a critical role in the biogenesis of microRNAs (miRNAs). miRNAs are small regulatory RNAs responsible for post-transcriptional gene silencing, controlling more than half of human protein-coding genes. This is achieved through the targeting and regulation of complementary RNA transcripts and has a well-documented role in post-t...... hiện toàn bộ
Characterisation of adenoid cystic carcinoma of the breast by immunohistology.Journal of Clinical Pathology - Tập 42 Số 5 - Trang 470-476 - 1989
W Düe, W D Herbst, V. Loy, H Stein
An adenoid cystic carcinoma of the breast in a 78 year old woman was analysed immunohistologically for the production of type IV collagen, the expression of vimentin, epithelial membrane antigen (EMA) and steroid receptors, and the proliferative activity of the tumour cells. The data were compared with those obtained in eight adenoid cystic carcinomas of salivary glands and in ductal carci...... hiện toàn bộ
MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreasJournal of Clinical Pathology - Tập 58 Số 8 - Trang 845-852 - 2005
Miyuki Saitou, Masamichi Goto, Michiko Horinouchi, Shugo Tamada, Kohji Nagata, Taiji Hamada, Masahiko Osako, Sonshin Takao, Surinder K. Batra, Takashi Aikou, K Imai, Suguru Yonezawa
Background:Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC.Aims:To investigate the prognostic significance of...... hiện toàn bộ