Mary J. Harner, Andreas O. Frank, Stephen W. Fesik
Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool
for fragment-based drug discovery over the last two decades. While NMR has been
traditionally used to elucidate the three-dimensional structures and dynamics of
biomacromolecules and their interactions, it can also be a very valuable tool
for the reliable identification of small molecules that bind to proteins and for
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