LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn’s diseaseJournal of Biomedical Science - Tập 20 - Trang 1-7 - 2013
Yu Qi Qiao, Mei Lan Huang, An Tao Xu, Di Zhao, Zhi Hua Ran, Jun Shen
Long non-coding RNAs (lncRNAs) have different functions in cells. They work as signals, decoys, guides, and scaffolds. Altered lncRNA levels can affect the expression of gene products. There are seldom studies on the role of lncRNAs in inflammatory bowel disease (IBD). Quantitative RT-PCR showed that DQ786243 was significantly overexpressed in clinical active CD patients compared with clinical ina...... hiện toàn bộ
Integrated miRNA and mRNA expression profiling in fetal hippocampus with Down syndromeJournal of Biomedical Science - - 2016
Wei-li Shi, Zhong-zhen Liu, Hong-dan Wang, Dong Wu, Hui Zhang, Hai Xiao, Yan Chu, Qiao-fang Hou, Shi-xiu Liao
Down syndrome (DS), caused by triplication of human chromosome 21, is the most common aneuploidies. The main characteristic of DS patients is intellectual disability. MicroRNAs (miRNAs) play important regulatory roles in various biological processes, such as embryonic development, cell differentiation, proliferation and apoptosis. Several miRNAs have shown association with DS. However, the role of...... hiện toàn bộ
Ser1333 phosphorylation indicates ROCKI activationJournal of Biomedical Science - Tập 20 - Trang 1-6 - 2013
Hsiang-Hao Chuang, Shao-Wei Liang, Zee-Fen Chang, Hsiao-Hui Lee
Two isoforms of Rho-associated protein kinase (ROCK), ROCKI and ROCKII, play a pivotal role in regulation of cytoskeleton and are involved in multiple cellular processes in mammalian cells. Knockout mice experiments have indicated that the functions of ROCKI and II are probably non-redundant in physiology. However, it is difficult to differentiate the activation status of ROCKI and ROCKII in biolo...... hiện toàn bộ
Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-κB pathwayJournal of Biomedical Science - Tập 17 - Trang 1-13 - 2010
Kou-Gi Shyu, Bao-Wei Wang, Chiu-Mei Lin, Hang Chang
Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expression, as well as the possible molecular mechanisms and signal pathways mediating the expression of TLR4 by cyclic mechanical stretch in cardiomyocytes. Neonatal Wistar rat cardiomyocytes grow...... hiện toàn bộ
Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategiesJournal of Biomedical Science - Tập 31 - Trang 1-16 - 2024
Yan-Ruide Li, Tyler Halladay, Lili Yang
Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to various other therapeutic modalities, tumor cells employ counterstrategies to manifest immune evasion, thereby circumventing the impact of CBIs. This phenomenon is facilitated by an intricate...... hiện toàn bộ
Basics and applications of tumor-derived extracellular vesiclesJournal of Biomedical Science - Tập 26 - Trang 1-17 - 2019
Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo, Tang-Long Shen
Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of can...... hiện toàn bộ