Journal of Biomedical Science
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Gene Therapy Strategies for Hepatocellular Carcinoma
Journal of Biomedical Science - Tập 13 - Trang 453-468 - 2006
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide. Effective therapy to this cancer is currently lacking, creating an urgent need for new therapeutic strategies for HCC. Gene therapy approach that relies on the transduction of cells with genetic materials, such as apoptotic genes, suicide genes, genes coding for antiangiogenic factors or immunomodulatory molecules, small...... hiện toàn bộ
Tiềm năng điều trị của endolysins virus thực khuẩn đối với các nhiễm trùng do vi khuẩn Gram dương Dịch bởi AI
Journal of Biomedical Science - Tập 30 - Trang 1-18 - 2023
Nhiễm trùng do vi khuẩn Gram dương (G+) là gánh nặng lớn đối với cả nguồn lực y tế và y tế cộng đồng. Sự gia tăng tần suất của vi khuẩn G+ kháng đa thuốc như Staphylococcus aureus kháng methicillin (MRSA) khiến cho việc phát triển các tác nhân kháng khuẩn mới trở nên cấp thiết cho việc điều trị các nhiễm trùng do vi khuẩn G+ gây ra. Endolysins là các enzym do virus thực khuẩn (phage) mã hóa, có kh...... hiện toàn bộ
#Gram-positive bacteria #endolysins #bacteriophage #antimicrobial agents #antibiotic resistance
Hepatitis B viral polymerase fusion proteins are biologically active and can interact with the hepatitis C virus core protein in vivo
Journal of Biomedical Science - Tập 8 - Trang 492-503 - 2001
Hepadnaviruses and retroviruses are evolutionarily related families because they both require a process of reverse transcription for genome replication. However, hepadnaviruses produce polymerase (pol) and core proteins separately, while retroviruses synthesize a gag-pol fusion protein that is subsequently cleaved by a virally encoded protease to release a functional polymerase. To test whether an...... hiện toàn bộ
Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction
Journal of Biomedical Science - Tập 13 - Trang 47-58 - 2005
Both cell therapy and angiogenic growth factor gene therapy have been applied to animal studies and clinical trials. Little is known about the direct comparison between cell therapy and angiogenic growth factor gene therapy. The goal of this study was to compare the effects of human bone marrow-derived mesenchymal stem cells (hMSCs) transplantation and injection of angiogenic growth factor genes i...... hiện toàn bộ
Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far
Journal of Biomedical Science - Tập 29 - Trang 1-17 - 2022
Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of phages and antibiotics separately or in combination both in animal models as well as in humans. The phenomenon of phage–antibiotic synergy, in which antibiotics may induce the production of ph...... hiện toàn bộ
Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella TyphimuriumAbstract
Background
yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S . Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonell... ... hiện toàn bộ
Journal of Biomedical Science -
SRF: a seriously responsible factor in cardiac development and disease
Journal of Biomedical Science - Tập 29 - Trang 1-21 - 2022
The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which highlights the importance of this organ in later stages of growth. Knowledge of the regulatory mechani...... hiện toàn bộ
Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells
Journal of Biomedical Science - Tập 13 - Trang 525-533 - 2006
Arsenic is an established human carcinogen. The role of aquaglyroporins (AQPs) in arsenic disposition was recently identified. In order to examine whether organic anion transporting polypeptide-C (OATP-C) also plays a role in arsenic transport, OATP-C cDNA was transfected into cells of a human embryonic kidney cell line (HEK-293). Transfection increased uptake of the model OATP-C substrate, estrad...... hiện toàn bộ
Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration
Journal of Biomedical Science - Tập 19 - Trang 1-12 - 2012
The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural development, and retinal degeneration. The purpose of this study was to investigate the role of Drosophila king tubby (ktub) in rhodopsin 1 (Rh1) endocytosis and retinal degeneration upon light sti...... hiện toàn bộ
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