Journal of Biomedical Science
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LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn’s disease
Journal of Biomedical Science - Tập 20 - Trang 1-7 - 2013
Long non-coding RNAs (lncRNAs) have different functions in cells. They work as
signals, decoys, guides, and scaffolds. Altered lncRNA levels can affect the
expression of gene products. There are seldom studies on the role of lncRNAs in
inflammatory bowel disease (IBD). Quantitative RT-PCR showed that DQ786243 was
significantly overexpressed in clinical active CD patients compared with
clinical ina...
Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization
Journal of Biomedical Science - Tập 13 Số 5 - Trang 695-702 - 2006
Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons
Journal of Biomedical Science - Tập 11 - Trang 482-492 - 2004
The present study was performed to examine the effects of acute ethanol exposure
on N-methyl-D-aspartate (NMDA)-induced responses and the development of acute
tolerance in rat rostral ventrolateral medulla (RVLM) in vivo and in vitro.
Repeated microinjections of NMDA (0.14 nmol) into the RVLM every 30 min caused
reproducible increases in mean arterial pressure in urethane-anesthetized rats
weighin...
An integrated method for cancer classification and rule extraction from microarray data
Journal of Biomedical Science - Tập 16 - Trang 1-10 - 2009
Different microarray techniques recently have been successfully used to
investigate useful information for cancer diagnosis at the gene expression level
due to their ability to measure thousands of gene expression levels in a
massively parallel way. One important issue is to improve classification
performance of microarray data. However, it would be ideal that influential
genes and even interpreta...
Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors
Journal of Biomedical Science - Tập 30 - Trang 1-19 - 2023
Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis
and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10)
contributes to distant migration of PDAC. The role of KLF10 in modulating
tumorigenesis and stem cell phenotypes of PDAC is unclear. Additional depletion
of KLF10 in KC (LSL: KrasG12D; Pdx1-Cre) mice, a spontaneous murine PDAC model,
was established...
Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice
Journal of Biomedical Science - Tập 15 - Trang 585-594 - 2008
We investigated the potency of exogenous bone marrow mesenchymal stem cells
(MSCs) to engraft into irradiated intestine, as well as these cells’ effects on
radiation-induced enteric injury. MSCs from β-Gal-transgenic mice were
transplanted into C57BL/6J recipient mice that received abdominal irradiation
(13 Gy). At different time points, recipient intestines were examined for the
engraftment of do...
ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer
Journal of Biomedical Science - Tập 27 Số 1 - 2020
Abstract Background ZNF322A is an oncogenic transcription factor that belongs to
the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests
that ZNF322A may contribute to the tumorigenesis of lung cancer, however, the
ZNF322A-mediated downstream signaling pathways remain unknown. Methods To
uncover ZNF322A-mediated functional network, we applied phosphopeptide
enrichment and isob...
Establishment and characterization of NS3 protein-specific T-cell clones from a patient with chronic hepatitis C
Journal of Biomedical Science - Tập 5 - Trang 290-296 - 1998
Our previous study showed dominant proliferative response of peripheral
mononuclear cells to hepatitis C virus (HCV) nonstructural (NS-3) (T9, from aa
1188 to 1493) in chronically infected patients. Six T9-specific T-cell clones
derived in an HCV patient were established and studied for the antigen
specificity and the ability of augmentation of in vitro antibody production. All
these cloned T-cell...
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