Journal of Biological Rhythms

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A Simpler Model of the Human Circadian Pacemaker
Journal of Biological Rhythms - Tập 14 Số 6 - Trang 533-538 - 1999
Daniel B. Forger, Megan E. Jewett, Richard E. Kronauer
Numerous studies have used the classic van der Pol oscillator, which contains a cubic nonlinearity, to model the effect of light on the human circadian pacemaker. Jewett and Kronauer demonstrated that Aschoff's rule could be incorporated into van der Pol type models and used a van der Pol type oscillator with higher order nonlinearities. Kronauer, Forger, and Jewett have proposed a model ...... hiện toàn bộ
Estimation of Human Circadian Phase via a Multi-Channel Ambulatory Monitoring System and a Multiple Regression Model
Journal of Biological Rhythms - Tập 26 Số 1 - Trang 55-67 - 2011
Vitaliy Kolodyazhniy, Jakub Späti, Sylvia R. Frey, Thomas Götz, Anna Wirz‐Justice, Kurt Kräuchi, Christian Cajochen, Frank H. Wilhelm
Reliable detection of circadian phase in humans using noninvasive ambulatory measurements in real-life conditions is challenging and still an unsolved problem. The masking effects of everyday behavior and environmental input such as physical activity and light on the measured variables need to be considered critically. Here, we aimed at developing techniques for estimating circadian phase...... hiện toàn bộ
Getting Through to Circadian Oscillators: Why Use Constant Routines?
Journal of Biological Rhythms - Tập 17 Số 1 - Trang 4-13 - 2002
Jeanne F. Duffy, Derk‐Jan Dijk
Overt 24-h rhythmicity is composed of both exogenous and endogenous components, reflecting the product of multiple (periodic) feedback loops with a core pacemaker at their center. Researchers attempting to reveal the endogenous circadian (near 24-h) component of rhythms commonly conduct their experiments under constant environmental conditions. However, even under constant environmental c...... hiện toàn bộ
Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data
Journal of Biological Rhythms - Tập 35 Số 2 - Trang 195-206 - 2020
Nora Stack, Jamie M. Zeitzer, Charles A. Czeisler, Cecilia Diniz Behn
The human circadian pacemaker entrains to the 24-h day, but interindividual differences in properties of the pacemaker, such as intrinsic period, affect chronotype and mediate responses to challenges to the circadian system, such as shift work and jet lag, and the efficacy of therapeutic interventions such as light therapy. Robust characterization of circadian properties requires desynchro...... hiện toàn bộ
A Model-Based Approach to Optimizing Ultradian Forced Desynchrony Protocols for Human Circadian Research
Journal of Biological Rhythms - Tập 32 Số 5 - Trang 485-498 - 2017
Nora Stack, David Barker, Mary A. Carskadon, Cecilia Diniz Behn
The human circadian system regulates internal 24-h rhythmicity and plays an important role in many aspects of human health and behavior. To investigate properties of the human circadian pacemaker such as intrinsic period and light sensitivity, experimental researchers have developed forced desynchrony (FD) protocols in which manipulations of the light-dark (LD) cycle are used to desynchro...... hiện toàn bộ
Daily Light Exposure Patterns Reveal Phase and Period of the Human Circadian Clock
Journal of Biological Rhythms - Tập 32 Số 3 - Trang 274-286 - 2017
Tom Woelders, Domien G. M. Beersma, Marijke C. M. Gordijn, Roelof A. Hut, Emma J. Wams
Macroscopic Models for Human Circadian Rhythms
Journal of Biological Rhythms - Tập 34 Số 6 - Trang 658-671 - 2019
Kevin M. Hannay, Victoria Booth, Daniel B. Forger
Mathematical models have a long and influential history in the study of human circadian rhythms. Accurate predictive models for the human circadian light response have been used to study the impact of a host of light exposures on the circadian system. However, generally, these models do not account for the physiological basis of these rhythms. We illustrate a new paradigm for deriving mod...... hiện toàn bộ
Are Individual Differences in Sleep and Circadian Timing Amplified by Use of Artificial Light Sources?
Journal of Biological Rhythms - Tập 32 Số 2 - Trang 165-176 - 2017
Krithika Swaminathan, Elizabeth B. Klerman, Andrew J. K. Phillips
Within the human population, there is large interindividual variability in the timing of sleep and circadian rhythms. This variability has been attributed to individual differences in sleep physiology, circadian physiology, and/or light exposure. Recent experimental evidence suggests that the latter is necessary to evoke large interindividual differences in sleep and circadian timing. We ...... hiện toàn bộ
Comparisons of the Variability of Three Markers of the Human Circadian Pacemaker
Journal of Biological Rhythms - Tập 17 Số 2 - Trang 181-193 - 2002
Elizabeth B. Klerman, Hayley B. Gershengorn, Jeanne F. Duffy, Richard E. Kronauer
A circadian pacemaker within the central nervous system regulates the approximately 24-h physiologic rhythms in sleep cycles, hormone secretion, and other physiologic functions. Because the pacemaker cannot be examined directly in humans, markers of pacemaker function must be used to study the pacemaker and its response to environmental stimuli. Core body temperature (CBT), plasma cortiso...... hiện toàn bộ
Review: On Mathematical Modeling of Circadian Rhythms, Performance, and Alertness
Journal of Biological Rhythms - Tập 22 Số 2 - Trang 91-102 - 2007
Elizabeth B. Klerman, Melissa St. Hilaire
Mathematical models of neurobehavioral performance and alertness have both basic science and practical applications. These models can be especially useful in predicting the effect of different sleep-wake schedules on human neurobehavioral objective performance and subjective alertness under many conditions. Several relevant models currently exist in the literature. In principle, the devel...... hiện toàn bộ
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