A Simpler Model of the Human Circadian Pacemaker

Journal of Biological Rhythms - Tập 14 Số 6 - Trang 533-538 - 1999
Daniel B. Forger1, Megan E. Jewett2, Richard E. Kronauer3
1Division of Engineering and Applied Sciences, Harvard University Cambridge, MA, 02138
2Circadian, Neuroendocrine and Sleep Disorders Section, 221 Longwood Avenue, Boston, MA, 02115
3Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; Circadian, Neuroendocrine and Sleep Disorders Section, 221 Longwood Avenue, Boston, MA, 02115

Tóm tắt

Numerous studies have used the classic van der Pol oscillator, which contains a cubic nonlinearity, to model the effect of light on the human circadian pacemaker. Jewett and Kronauer demonstrated that Aschoff's rule could be incorporated into van der Pol type models and used a van der Pol type oscillator with higher order nonlinearities. Kronauer, Forger, and Jewett have proposed a model for light preprocessing, Process L, representing a biochemical process that converts a light signal into an effective drive on the circadian pacemaker. In the paper presented here, the authors use the classic van der Pol oscillator with Process L and Jewett and Kronauer's model of Aschoff's rule to model the human circadian pacemaker. This simpler cubic model predicts the results of a three-pulse human phase response curve experiment and a two-pulse amplitude reduction study with as much, or more, accuracy as the models of Jewett and Kronauer and Kronauer, Forger, and Jewett, which both employ a nonlinearity of degree 7. This suggests that this simpler cubic model should be considered as a potential alternative to other models of the human circadian system currently available.

Từ khóa


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Thông tin xuất bản

Journal of Biological Rhythms

Tập 14 Số 6

533-538

Thông tin tác giả