Life between Clocks: Daily Temporal Patterns of Human Chronotypes Tập 18 Số 1 - Trang 80-90 - 2003
Till Roenneberg, Anna Wirz‐Justice, Martha Merrow
Human behavior shows large interindividual variation in temporal organization.
Extreme “larks” wake up when extreme “owls” fall asleep. These chronotypes are
attributed to differences in the circadian clock, and in animals, the genetic
basis of similar phenotypic differences is well established. To better
understand the genetic basis of temporal organization in humans, the authors
developed a ques... hiện toàn bộ
Salivary Melatonin as a Circadian Phase Marker: Validation and Comparison to Plasma Melatonin Tập 12 Số 5 - Trang 457-466 - 1997
Athena Voultsios, David J. Kennaway, Drew Dawson∥
There are many situations in which it would be useful to know the phase state of
the biological clock. It is recognized that measurement of melatonin levels can
provide this information, but traditionally blood has been used for the
analysis, and there are many problems in extending the measurements into the
home or field situations. The aim of this study was to develop and validate a
salivary mel... hiện toàn bộ
EEG Power Density during Nap Sleep: Reflection of an Hourglass Measuring the Duration of Prior Wakefulness Tập 2 Số 3 - Trang 207-219 - 1987
Derk‐Jan Dijk, Domien G. M. Beersma, Serge Daan
The relation between the duration of prior wakefulness and EEG power density
during sleep in humans was assessed by means of a study of naps. The duration of
prior wakefulness was varied from 2 to 20 hr by scheduling naps at 1000 hr, 1200
hr, 1400 hr, 1600 hr, 1800 hr, 2000 hr, and 0400 hr. In contrast to sleep
latencies, which exhibited a minimum in the afternoon, EEG power densities in
the delta... hiện toàn bộ
Getting Through to Circadian Oscillators: Why Use Constant Routines? Tập 17 Số 1 - Trang 4-13 - 2002
Jeanne F. Duffy, Derk‐Jan Dijk
Overt 24-h rhythmicity is composed of both exogenous and endogenous components,
reflecting the product of multiple (periodic) feedback loops with a core
pacemaker at their center. Researchers attempting to reveal the endogenous
circadian (near 24-h) component of rhythms commonly conduct their experiments
under constant environmental conditions. However, even under constant
environmental conditions... hiện toàn bộ
Comparisons of the Variability of Three Markers of the Human Circadian Pacemaker Tập 17 Số 2 - Trang 181-193 - 2002
Elizabeth B. Klerman, Hayley B. Gershengorn, Jeanne F. Duffy, Richard E. Kronauer
A circadian pacemaker within the central nervous system regulates the
approximately 24-h physiologic rhythms in sleep cycles, hormone secretion, and
other physiologic functions. Because the pacemaker cannot be examined directly
in humans, markers of pacemaker function must be used to study the pacemaker and
its response to environmental stimuli. Core body temperature (CBT), plasma
cortisol, and pl... hiện toàn bộ
A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins Tập 13 Số 1 - Trang 70-87 - 1998
Jean‐Christophe Leloup, Albert Goldbeter
The authors present a model for circadian oscillations of the Period (PER) and
Timeless (TIM) proteins in Drosophila. The model for the circadian clock is
based on multiple phosphorylation of PER and TIM and on the negative feedback
exerted by a nuclear PER-TIM complex on the transcription of the perand tim
genes. Periodic behavior occurs in a large domain of parameter space in the form
of limit c... hiện toàn bộ
Validation of Horne and Ostberg Morningness-Eveningness Questionnaire in a Middle-Aged Population of French Workers Tập 19 Số 1 - Trang 76-86 - 2004
Jacques Taillard, Pierre Philip, Jean‐François Chastang, Bernard Bioulac
As suggested by the authors, the Horne and Ostberg morning/evening questionnaire
(MEQ) has never been adapted to evaluate a nonstudent population. The purpose of
this study was to validate this MEQ in a sample of middle-aged workers by
modifying only the cutoffs. It was administered in 566 non-shift-workers aged
51.2 to 3.2 years who presented no sleep disorders. According to the Horne and
Ostberg... hiện toàn bộ
Serotonin and the Mammalian Circadian System: II. Phase-Shifting Rat Behavioral Rhythms with Serotonergic Agonists Tập 8 Số 1 - Trang 17-31 - 1993
Dale M. Edgar, Joseph D. Miller, Rebecca A. Prosser, Robin R. Dean, William C. Dement
The suprachiasmatic nuclei (SCN) receive primary afferents from the median and
dorsal raphe, but the role of these projections in circadian timekeeping is
poorly understood. Studies of the SCN in vitro suggest that quipazine, a general
serotonin (5-HT) receptor agonist, can produce circadian time-dependent phase
advances and phase delays in circadian rhythms of neuronal activity. The present
study... hiện toàn bộ
Stability of Melatonin and Temperature as Circadian Phase Markers and Their Relation to Sleep Times in Humans Tập 20 Số 2 - Trang 178-188 - 2005
Susan Benloucif, M. J. Guico, Kathryn J. Reid, Lisa F. Wolfe, M L’Hermite-Baleriaux, Phyllis C. Zee
Circadian rhythms of core body temperature and melatonin are commonly used as
phase markers of the circadian clock. Melatonin is a more stable marker of
circadian phase when measured under constant routine conditions. However, little
is known about the variability of these phase markers under less controlled
conditions. Moreover, there is little consensus about the preferred method of
analysis. Th... hiện toàn bộ
Activity Feedback to the Mammalian Circadian Pacemaker: Influence on Observed Measures of Rhythm Period Length Tập 6 Số 3 - Trang 185-199 - 1991
Dale M. Edgar, Connie E. Martin, William C. Dement
In the mouse, activity is precisely timed by the circadian clock and is normally
most intense in the early subjective night. Since vigorous activity (e.g., wheel
running) is thought to induce phase shifts in rodents, the temporal placement of
daily exercise/activity could be a determinant of observed circadian rhythm
period. The relationship between spontaneous running-wheel activity and the
circa... hiện toàn bộ