Katherine H. Thompson, Barry D. Liboiron, Sun Yan, Karycia D. Bellman, Ika A. Setyawati, Brian O. Patrick, Veranja Karunaratne, Gulnar Rawji, J.Ross Wheeler, Kymberley Sutton, Sanjay Bhanot, Carrie Cassidy, John H. McNeill, Violet G. Yuen, Chris Orvig
Several pentavalent antimony compounds have been used for the treatment of
leishmaniasis for decades. However, the mechanism of these antimony drugs still
remains unclear. One of their targets is thought to be trypanothione, a major
low molecular mass thiol inside the parasite. We show that pentavalent antimony
(SbV) can be rapidly reduced to its trivalent state by trypanothione at mildly
acidic c... hiện toàn bộ