Vladimir Pelmenschikov, Margareta R. Blomberg, Per E. Siegbahn
The catalytic mechanism for peptide hydrolysis by thermolysin has been investigated using the B3LYP hybrid density functional method. The starting structure for the calculations was based on the X-ray crystal structure of the enzyme inhibited with the ZF
p
LA phosphonamidate transition-state analogue. Besides the three Zn ligands His142, His146 and Glu166, a few ...... hiện toàn bộ
Katherine H. Thompson, Barry D. Liboiron, Sun Yan, Karycia D. Bellman, Ika A. Setyawati, Brian O. Patrick, Veranja Karunaratne, Gulnar Rawji, J.Ross Wheeler, Kymberley Sutton, Sanjay Bhanot, Carrie Cassidy, John H. McNeill, Violet G. Yuen, Chris Orvig