Invertebrate Neuroscience
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Neurobiology of plant parasitic nematodes
Invertebrate Neuroscience - Tập 11 - Trang 9-19 - 2011
The regulatory constraints imposed on use of chemical control agents in agriculture are rendering crops increasingly vulnerable to plant parasitic nematodes. Thus, it is important that new control strategies which meet requirements for low toxicity to non-target species, vertebrates and the environment are pursued. This would be greatly facilitated by an improved understanding of the physiology an......
Neurodegenerative mutants in Drosophila: a means to identify genes and mechanisms involved in human diseases?
Invertebrate Neuroscience - Tập 5 - Trang 97-109 - 2005
There are 50 ways to leave your lover (Simon 1987) but many more to kill your brain cells. Several neurodegenerative diseases in humans, like Alzheimer’s disease, have been intensely studied but the underlying cellular and molecular mechanisms are still unknown for most of them. For those syndromes where associated gene products have been identified their biochemistry and physiological as well as ......
Evolution of the techniques used in studying associative olfactory learning and memory in adult Drosophila in vivo: a historical and technical perspective
Invertebrate Neuroscience - Tập 14 Số 1 - Trang 1-11 - 2014
Pretreatment of the cockroach cercal afferent/giant interneuron synapses with nicotinoids and neonicotinoids differently affects acetylcholine and nicotine-induced ganglionic depolarizations
Invertebrate Neuroscience - Tập 13 - Trang 91-97 - 2013
We have recently demonstrated that neonicotinoid insecticides were able to act as agonists of postsynaptic nicotinic acetylcholine receptors (nAChRs) expressed at the synapse between the cercal nerve XI and the giant interneurons, in the sixth abdominal ganglion. In this work, we demonstrated that nicotinoids such as nornicotine acted as an agonist of nicotinic acetylcholine receptors expressed at......
Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics
Invertebrate Neuroscience - Tập 12 Số 1 - Trang 3-12 - 2012
Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist
Invertebrate Neuroscience - Tập 3 - Trang 251-259 - 1997
Naturally occurring toxins can often serve as useful chemical tools for investigating signalling processes in nervous and other systems. Tetrodotoxin and alpha-bungarotoxin are prime examples of toxins which are widely used in neurobiological research. Some toxins may also become molecular models for designing new drugs. Usually drugs are small, non-peptide molecules, as these display better bioav......
Cellular mechanisms governing synapse formation: lessons from identified neurons in culture
Invertebrate Neuroscience - Tập 2 - Trang 1-8 - 1996
The accessibility of embryonic and adult neurons within invertebrate nervous systems has made them excellent subjects for neurobiological study. The ability to readily identify individual neurons, together with their great capacity for regeneration, has been especially beneficial to investigations of synapse formation and the specificity of neuronal connectivity. Many invertebrate neurons survive ......
Molecular identification and expression of the NMDA receptor NR1 subunit in the leech
Invertebrate Neuroscience - Tập 9 - Trang 11-20 - 2009
The N-methyl-d-aspartate receptor (NMDAR) is involved in a number of physiological and pathophysiological processes in vertebrates, but there have been few studies examining the role of invertebrate NMDA receptors. In the leech, pharmacological evidence suggests that NMDARs contribute to synaptic plasticity, but there has been no molecular identification of NMDA receptors. In this report, a partia......
Elements of the olfactory signaling pathways in insect antennae
Invertebrate Neuroscience - Tập 3 - Trang 137-144 - 1997
Owing to their enormous ability to recognize airborne molecules, insects have long been used as model systems for studying various aspects of olfaction. Modern biological techniques have opened new avenues for exploring the molecular mechanisms underlying the complex signaling processes in chemosensory neurons. Biochemical and molecular analyses have allowed the identification of molecular element......
Activation of two forms of locomotion by a previously identified trigger interneuron for swimming in the medicinal leech
Invertebrate Neuroscience - - 2008
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