Chapter Five Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheral neuropathyInternational Review of Neurobiology - Tập 145 - Trang 83 - 2019
Flatters Sarah J.L., Trecarichi Annalisa
Several first-line chemotherapeutic agents, including taxanes, platinum agents and proteasome inhibitors, are associated with the dose-limiting side effect of chemotherapy-induced peripheral neuropathy (CIPN). CIPN predominantly manifests as sensory symptoms, which are likely due to drug accumulation within peripheral nervous tissues rather than the central nervous system. No treatment is currentl...... hiện toàn bộ
#Pain #Neuron #Neurotoxicity #Reactive oxygen species #Paclitaxel #Oxaliplatin #Bortezomib #Cisplatin #Vincristine #Ixabepilone