International Journal of Laboratory Hematology
SCIE-ISI SCOPUS (2007-2025)
1751-553X
1751-5521
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
Biochemistry (medical)HematologyClinical BiochemistryMedicine (miscellaneous)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Platelets: bridging hemostasis, inflammation, and immunity
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SummaryAlthough the function of platelets in the maintenance of hemostasis has
been studied in great detail, more recent evidence has highlighted a central
role for platelets in the host inflammatory and immune responses. Platelets by
virtue of their large numbers and their ability to rapidly release a broad
spectrum of immunomodulatory cytokines, chemokines, and other mediators act as
circulating...
Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the β‐thalassaemia minor from iron deficiency in Palestinian population
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Summaryβ‐thalassaemia minor and iron deficiency are the most common causes of
microcytosis and/or hypochromasia. The present study evaluates the diagnostic
reliability of different RBC indices and formulas, as well as our proposed
formula, in the differentiation of the β‐thalassaemia minor from iron deficiency
in Palestinian population. Complete blood count (CBC) parameters of 2196
certainly diagn...
Selected Stro‐1‐enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation
Tập 31 Số 1 - Trang 9-19 - 2009
SummaryMesenchymal stem cells (MSCs) have an immunosuppressive effect and can
inhibit the proliferation of alloreactive T cells in vitro and in vivo.
Cotransplantation of MSCs and hematopoietic stem cells (HSCs) from HLA‐identical
siblings has been shown to reduce the incidence of acute graft‐vs.‐host disease.
MSCs are heterogeneous and data on the inhibitory effects of different MSC
subsets are l...
Technical issues: flow cytometry and rare event analysis
Tập 35 Số 3 - Trang 344-350 - 2013
SummaryFlow cytometry has become an essential tool for identification and
characterization of hematological cancers and now, due to technological
improvements, allows the identification and rapid enumeration of small tumor
populations that may be present after induction therapy (minimal residual
disease, MRD). The quantitation of MRD has been shown to correlate with relapse
and survival rates in n...
Thrombosis and antiphospholipid antibodies in patients with SARS‐COV‐2 infection (COVID‐19)
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Comparison of the MagNA pure LC automated system and the RiboPure‐Blood RNA manual method for RNA extraction from multiple myeloma bone marrow samples conserved in an RNA stabilizer
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SummaryA total of 62 frozen bone marrow specimens conserved in RNA later®
(Ambion) were processed using two different extraction methods, the MagNA Pure
LC system (MAG; Roche) and the manual RiboPure‐Blood RNA method (RIBO; Ambion);
Beta glucoronidase RNA (GUS) was amplified by LightCycler PCR to evaluate the
quality of both extraction procedures. Less than 1000 GUS copies/ml was detected
in 26 of...
GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients
Tập 43 Số 4 - Trang 713-723 - 2021
AbstractIntroductionAccurate detection of GATA1 mutation is highly significant
in patients with acute myeloid leukemia (AML) and trisomy 21 as it allows
optimization of clinical protocol. This study was aimed at (a) enhanced search
for GATA1 mutations; and (b) characterization of molecular landscapes for such
conditions.MethodsThe DNA samples from 44 patients with newly diagnosed de novo
AML with ...
Proteomics analysis reveals alterations of NK cells in patients with severe aplastic anemia
Tập 42 Số 3 - Trang 308-315 - 2020
AbstractIntroductionSevere aplastic anemia (SAA) is a disease characterized by
severe pancytopenia and hematopoietic failure of bone marrow. Natural killer
(NK) cells are a class of large granular lymphocytes that perform killing and
immunomodulatory functions. Our previous study demonstrated that NK cells played
the “protective” role in SAA, which is weakened. However, the mechanism remains
uncle...
Routine blood biomarkers for the detection of multiple myeloma using machine learning
Tập 44 Số 3 - Trang 558-566 - 2022
AbstractIntroductionPrimary laboratory tests performed in the diagnosis of
multiple myeloma (MM) include bone marrow examination and free light chain
assay; however, these may only be ordered after clinical suspicion of disease.
In contrast, routine blood test results are readily available.MethodsMachine
learning algorithms (ML) combined with routine blood tests were used to detect
MM. Feature sel...