International Journal of Laboratory Hematology

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Platelets: bridging hemostasis, inflammation, and immunity
International Journal of Laboratory Hematology - Tập 35 Số 3 - Trang 254-261 - 2013
Craig N. Jenne, Rossana Urrutia, Paul Kubes
SummaryAlthough the function of platelets in the maintenance of hemostasis has been studied in great detail, more recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. Platelets by virtue of their large numbers and their ability to rapidly release a broad spectrum of immunomodulatory cyto...... hiện toàn bộ
Comparison of the MagNA pure LC automated system and the RiboPure‐Blood RNA manual method for RNA extraction from multiple myeloma bone marrow samples conserved in an RNA stabilizer
International Journal of Laboratory Hematology - Tập 29 Số 2 - Trang 139-144 - 2007
Guillermo García‐Effrón, Soledad Gamarra, Almudena Crooke, Pilar Martínez‐Sánchez, Juan José Lahuerta, Joaquín Martínez‐López
SummaryA total of 62 frozen bone marrow specimens conserved in RNA later® (Ambion) were processed using two different extraction methods, the MagNA Pure LC system (MAG; Roche) and the manual RiboPure‐Blood RNA method (RIBO; Ambion); Beta glucoronidase RNA (GUS) was amplified by LightCycler PCR to evaluate the quality ...... hiện toàn bộ
Technical issues: flow cytometry and rare event analysis
International Journal of Laboratory Hematology - Tập 35 Số 3 - Trang 344-350 - 2013
Benjamin D. Hedley, Michael Keeney
SummaryFlow cytometry has become an essential tool for identification and characterization of hematological cancers and now, due to technological improvements, allows the identification and rapid enumeration of small tumor populations that may be present after induction therapy (minimal residual disease, hiện toàn bộ
Proteomics analysis reveals alterations of NK cells in patients with severe aplastic anemia
International Journal of Laboratory Hematology - Tập 42 Số 3 - Trang 308-315 - 2020
Hui Liu, Tian Zhang, Yingying Chen, Chunyan Liu, Weiwei Qi, Yuanyuan Shao, Hong Yu, Tong Chen, Shaoxue Ding, Yang Li, Ting Wang, Zonghong Shao, Rong Fu
AbstractIntroductionSevere aplastic anemia (SAA) is a disease characterized by severe pancytopenia and hematopoietic failure of bone marrow. Natural killer (NK) cells are a class of large granular lymphocytes that perform killing and immunomodulatory functions. Our previous study demonstrated that NK cells played the “protective” ...... hiện toàn bộ
GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients
International Journal of Laboratory Hematology - Tập 43 Số 4 - Trang 713-723 - 2021
А. В. Панферова, Marina Gaskova, Eugenyi Nikitin, Pavel Baryshev, Natalia Timofeeva, Anna Kazakova, V. E. Matveev, Ekaterina Mikhailova, А. М. Попов, И. И. Калинина, Lili Hachatrian, Aleksey Maschan, Michael Maschan, Galina Novichkova, Yulia Olshanskaya
AbstractIntroductionAccurate detection of GATA1 mutation is highly significant in patients with acute myeloid leukemia (AML) and trisomy 21 as it allows optimization of clinical protocol. This study was aimed at (a) enhanced search for GATA1 mutations; and (b) characterization ...... hiện toàn bộ
COVID‐19 patient with immune thrombocytopenic purpura
International Journal of Laboratory Hematology - Tập 42 Số 6 - 2020
Tariq Kewan, Farah Almhana, L. Schwartzman, Hamed Daw, Abdo Haddad
Thrombosis and antiphospholipid antibodies in patients with SARS‐COV‐2 infection (COVID‐19)
International Journal of Laboratory Hematology - Tập 42 Số 6 - 2020
Xabier Gutiérrez López de Ocáriz, Nerea Castro Quismondo, Elena Vera Guerrero, Mario Rodríguez, Rosa Ayala, Joaquín Martínez‐López
Selected Stro‐1‐enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation
International Journal of Laboratory Hematology - Tập 31 Số 1 - Trang 9-19 - 2009
Aisha Nasef, Y. Z. ZHANG, Christelle Mazurier, Sandrine Bouchet, Morad Bensidhoum, Sabine François, N C Gorin, M López, Dominique Thierry, L Fouillard, Alain Chapel
SummaryMesenchymal stem cells (MSCs) have an immunosuppressive effect and can inhibit the proliferation of alloreactive T cells in vitro and in vivo. Cotransplantation of MSCs and hematopoietic stem cells (HSCs) from HLA‐identical siblings has been shown to reduce the incidence of acute graft‐vs... hiện toàn bộ
Routine blood biomarkers for the detection of multiple myeloma using machine learning
International Journal of Laboratory Hematology - Tập 44 Số 3 - Trang 558-566 - 2022
Gaowei Fan, Ruifang Cui, Qian Zhang, Shunli Zhang, Ruipeng Guo, Yixuan Zhai, Yuhong Yue, Qingtao Wang
AbstractIntroductionPrimary laboratory tests performed in the diagnosis of multiple myeloma (MM) include bone marrow examination and free light chain assay; however, these may only be ordered after clinical suspicion of disease. In contrast, routine blood test results are readily available.... hiện toàn bộ
Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the β‐thalassaemia minor from iron deficiency in Palestinian population
International Journal of Laboratory Hematology - Tập 30 Số 4 - Trang 324-330 - 2008
Mahmoud M. Sirdah, Issa S. Tarazi, Esmat Najjar, Rula Haddad
Summaryβ‐thalassaemia minor and iron deficiency are the most common causes of microcytosis and/or hypochromasia. The present study evaluates the diagnostic reliability of different RBC indices and formulas, as well as our proposed formula, in the differentiation of the β‐thalassaemia minor from iron deficiency in Palestinian population. Complete blood count (CBC) p...... hiện toàn bộ
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