International Journal of Clinical and Laboratory Research
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Determination of serum levels of complement component C4b-binding protein: influence of age and inflammation
International Journal of Clinical and Laboratory Research - Tập 21 - Trang 171-175 - 1992
C4b-binding protein (C4b-BP) is a high molecular weight plasma protein which inhibits the activity of the classical complement pathway C3 convertase. In addition to multiple binding sites for C4b, C4b-BP possesses a single binding site for vitamin K-dependent protein S, an inhibitor of blood coagulation. As protein S bound to C4b-BP has no anticoagulant activity, C4b-BP participates in the regulat...... hiện toàn bộ
A letter from the editor
International Journal of Clinical and Laboratory Research - Tập 21 - Trang 151-151 - 1992
Deadtime correction in high count rate quantitative dynamic studies with computer-assisted Anger-cameras
International Journal of Clinical and Laboratory Research - Tập 6 - Trang 182-190 - 1976
The use of tracers with high radioactivity in rapid dynamic quantitative studies (such as radioisotope angiocardiography), performed by the Anger-camera and data-processor, makes it possible to obtain a high counting rate. For correct interpretation of the results of the analysis of activity/time curves in regions of interest, the authors determined, under different working conditions, the deadtim...... hiện toàn bộ
Amyloidosis
International Journal of Clinical and Laboratory Research - Tập 4 - Trang 1-13 - 1974
Recenti ricerche hanno fornito i seguenti dati sull’amiloide: 1) esso ha natura proteica fibrillare, con catatteristico aspetto al microscopio elettronico e alla diffrazione ai raggi X; 2) esistono due tipi immunochimici principali delle proteine dell’amiloide: il primo è correlate con le catene leggere delle immunoglobuline, il secondo è una proteina finora non identificata. Il primo si riscontra...... hiện toàn bộ
Clinical use of fibronectin
International Journal of Clinical and Laboratory Research - Tập 13 - Trang 43-54 - 1983
There is considerable experimental evidence that the RES is an important host defense system in critical illness. The role of fibronectin in the control of RES phagocytic function and the potential for fibronetin therapy to ameliorate or reverse multisystem organ failure in critically ill patients are less well documented. This documentation may be difficult to accrue in the clinical setting becau...... hiện toàn bộ
Approaches to the evaluation of histocompatibility antigens
International Journal of Clinical and Laboratory Research - Tập 4 - Trang 527-539 - 1974
The strong transplantation antigens (called histocompatibility or H antigens) in a number of species are determined by genes of a single genetic complex — the major histocompatibility complex. While there are other H antigens which, if different in two individuals, can lead to graft rejection, it is the antigens of the major histocompatibility complex which are of overwhelming importance. These an...... hiện toàn bộ
Clinical implications of hepatitis B virus envelope protein variation
International Journal of Clinical and Laboratory Research - Tập 24 - Trang 80-85 - 1994
The envelope proteins of hepatitis B virus are highly conserved. They are involved in viral attachment to hepatocytes, virion assembly and secretion and induction of humoral and T-cell immune responses. The major neutralisation epitope is located within the S protein and is conformation dependent, probably due to the formation of disulphide bridges. Variation in the envelope proteins of hepatitis ...... hiện toàn bộ
Current plasmapheresis practice in the United States
International Journal of Clinical and Laboratory Research - Tập 13 - Trang 11-19 - 1983
The principal differences of the USA plasmapheresis collection system from most other countries are: it is conducted by the pharmaceutical industry rather than government, it uses remunerated donors, and it draws a larger volume of plasma than is permitted elsewhere. The implications of these features are reviewed in terms of the effects on donors and the effects on the plasma supply. Protein meta...... hiện toàn bộ
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