International Journal of Breast Cancer

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Target Points in Trastuzumab Resistance
International Journal of Breast Cancer - Tập 2012 - Trang 1-9 - 2012
Sahar Shojaei, Mossa Gardaneh, A Rahimi Shamabadi
Epidermal growth factor (EGF) family of receptors is involved in cell growth and differentiation. The human EGF2 (HER2) lacks natural ligands, and correlation between HER2 levels and carcinogenesis makes the receptor an ideal candidate for targeted therapy in breast cancer. Trastuzumab is a humanized antibody applied against HER2-positive breast tumors in clinic. Metastatic tumors respond ...... hiện toàn bộ
Utilization of Oncotype DX in an Inner City Population: Race or Place?
International Journal of Breast Cancer - Tập 2013 - Trang 1-3 - 2013
Amber Guth, Susan Fineberg, Kezhen Fei, Rebeca Franco, Nina A. Bickell
Oncotype DX, a 21-gene-array analysis, can guide chemotherapy treatment decisions for women with ER+ tumors. Of 225 ER+ women participating in a patient assistance trial, 23% underwent Oncotype DX testing: 31% of whites, 21% of blacks, and 14% of Hispanics (P=0.04) were tested. Only 3 white women were treated at municipal hospitals and none was tested. 3% of women treated in municipal hospital as compared to 30% treated at tertiary referral centers were tested (P=0.001). Within tertiary referral centers, there was no racial difference in testing: 32% of whites, 29% of blacks, and 19% of Hispanics (P=0.25). Multivariate analysis (model c-statistic = 0.76;P<0.0001) revealed that women who underwent testing were more likely to have stage 1B (RR=1.70; 95% CI: 1.45–1.85) and to be treated after 2007 (RR=1.34; 95% CI: 1.01–1.65) and less likely to be treated at a municipal hospital ( hiện toàn bộ
Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)
International Journal of Breast Cancer - Tập 2011 - Trang 1-6 - 2011
Poornima Devi, M. Saravana Kumar, Sourav Das
Breast cancer is a leading cause of death in women worldwide both in the developed and developing countries. Thus effective treatment of breast cancer with potential antitumour drugs is important. In this paper, human breast cancer cell line MCF-7 has been employed to evaluate the antiproliferative activity of red sorghum bran anthocyanin. The present investigation showed that red sorghum ...... hiện toàn bộ
Drug Resistance and the Role of Combination Chemotherapy in Improving Patient Outcomes
International Journal of Breast Cancer - Tập 2013 - Trang 1-15 - 2013
Denise A. Yardley
Resistance to cancer chemotherapy is a common phenomenon especially in metastatic breast cancer (MBC), a setting in which patients typically have had exposure to multiple lines of prior therapy. The subsequent development of drug resistance can result in rapid disease progression during or shortly after completion of treatment. Moreover, cross-class multidrug resistance limits patient trea...... hiện toàn bộ
Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer
International Journal of Breast Cancer - Tập 2011 - Trang 1-6 - 2011
Jorge Luis Soriano, Noyde Batista, Eduardo Santiesteban, M.C.P. Lima, Javier Ernesto Barreras González, Robin García, Yohanka Zarza, María V. López, Myriam Rodríguez, Jorge L. Loys, Narciso Montejo, Frank V. Aguirre, Amparo Macías, Ana María Vázquez
The use of low doses of cytotoxic agents continuously for prolonged periods is an alternative for the treatment of patients with metastatic breast cancer who have developed resistance to conventional chemotherapy. The combination of metronomic chemotherapy with therapeutic vaccines might increase the efficacy of the treatment. Twenty one patients with metastatic breast cancer in progressio...... hiện toàn bộ
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