Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)

International Journal of Breast Cancer - Tập 2011 - Trang 1-6 - 2011
Poornima Devi1, M. Saravana Kumar1, Sourav Das2
1P.G. Department of Biotechnology, Dr. Mahalingam Centre for Research and Development, NGM College, Pollachi 642001, India
2Kamadhenu Arts and Science College, Sathyamangalam 638503, India

Tóm tắt

Breast cancer is a leading cause of death in women worldwide both in the developed and developing countries. Thus effective treatment of breast cancer with potential antitumour drugs is important. In this paper, human breast cancer cell line MCF-7 has been employed to evaluate the antiproliferative activity of red sorghum bran anthocyanin. The present investigation showed that red sorghum bran anthocyanin induced growth inhibition of MCF-7 cells at significant level. The growth inhibition is dose dependent and irreversible in nature. When MCF-7 cells were treated with red sorghum bran anthocyanins due to activity of anthocyanin morphological changes were observed. The morphological changes were identified through the formation of apoptopic bodies. The fragmentation by these anthocyanins on DNA to oligonuleosomal-sized fragments, is a characteristic of apoptosis, and it was observed as concentration-dependent. Thus, this paper clearly demonstrates that human breast cancer cell MCF-7 is highly responsive by red sorghum bran anthocyanins result from the induction of apoptosis in MCF-7 cells.

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Tài liệu tham khảo

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Thông tin xuất bản

International Journal of Breast Cancer

Tập 2011

1-6

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