Genetics of autoimmune diseases: perspectives from genome-wide association studiesInternational Immunology - Tập 28 Số 4 - Trang 155-161 - 2016
Yuta Kochi
Abstract Genome-wide association studies (GWASs) for autoimmune diseases (ADs)
have identified many risk loci and have provided insights into the etiology of
each disease. Some of these loci, such as PTPN22 , IL23R and STAT4 , are shared
among different ADs, and the combination of risk loci may determine an
individual’s susceptibility for a disease. The majority of GWAS loci are
expression quantit... hiện toàn bộ
The roles of aryl hydrocarbon receptor in immune responsesInternational Immunology - Tập 25 Số 6 - Trang 335-343 - 2013
Nam‐Trung Nguyen, Hamza Hanieh, Taisuke Nakahama, Tadamitsu Kishimoto
AbstractA number of recent studies have examined the functions of aryl
hydrocarbon receptor (Ahr) in the immune system. Also known as dioxin receptor,
Ahr is a ligand-activated transcription factor that serves as a receptor for
various environmental toxins. The functions of Ahr in T cells depend on the
specific ligand bound to the receptor. For instance, binding of
2,3,7,8-tetrachlorodibenzo-p-dio... hiện toàn bộ