Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies

Glennie, M. J. and Johnson, P. W. 2000. Clinical trials of antibody therapy. Immunol. Today21:403,

Saleh, M. N., Khazaeli, M. B., Wheeler, R. H., Dropcho, E., Liu, T., Urist, M., Miller, D. M., Lawson, S., Dixon, P. and Russell, C. H. 1992. Phase I trial of the murine monoclonal anti-GD2 antibody 14G2a in metastatic melanoma. Cancer Res.52:4342.

Frodin, J. E., Lefvert, A. K. and Mellstedt, H. 1990. Pharmacokinetics of the mouse monoclonal antibody 17-1A in cancer patients receiving various treatment schedules. Cancer Res.50:4866.

Borrebaeck, C. K., Malmborg, A. C. and Ohlin, M. 1993. Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics? Immunol. Today14:477.

Junghans, R. P. 1999. Anti-Gal antibodies—where's the beef? Nat. Biotechnol.17:938.

Simister, N. E. and Mostov, K. E. 1989. An Fc receptor structurally related to MHC class I antigens. Nature337:184.

Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y. and Ward, E. S. 1996. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur. J. Immunol.26:690.

Junghans, R. P. and Anderson, C. L. 1996. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc. Natl Acad. Sci. USA93:5512.

Israel, E. J., Wilsker, D. F., Hayes, K. C., Schoenfeld, D. and Simister, N. E. 1996. Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn. Immunology89:573.

Israel, E. J., Patel, V. K., Taylor, S. F., Marshak-Rothstein, A. and Simister, N. E. 1995. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J. Immunol.154:6246.

Ellinger, I., Schwab, M., Stefanescu, A., Hunziker, W. and Fuchs, R. 1999. IgG transport across trophoblast-derived BeWo cells: a model system to study IgG transport in the placenta. Eur. J. Immunol.29:733.

McCarthy, K. M., Yoong, Y. and Simister, N. E. 2000. Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia. J. Cell Sci.113:1277

Ghetie, V. and Ward, E. S. 2000. Multiple roles for the major histocompatibility complex class I-related receptor FcRn. Annu. Rev. Immunol.18:739.

Medesan, C., Radu, C., Kim, J. K., Ghetie, V. and Ward, E. S. 1996. Localization of the site of the IgG molecule that regulates maternofetal transmission in mice. Eur. J. Immunol.26:2533.

Popov, S., Hubbard, J. G., Kim, J., Ober, B., Ghetie, V. and Ward, E. S. 1996. The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn. Mol. Immunol.33:521.

Medesan, C., Matesoi, D., Radu, C., Ghetie, V. and Ward, E. S. 1997. Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. J. Immunol.158:2211.

Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J. and Ward, E. S. 1997. Increasing the serum persistence of an IgG fragment by random mutagenesis. Nat. Biotechnol.15:637.

Story, C. M., Mikulska, J. E. and Simister, N. E. 1994. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J. Exp. Med.180:2377.

Simister, N. E., Story, C. M., Chen, H. L. and Hunt, J. S. 1996. An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta. Eur. J. Immunol.26:1527.

Kristoffersen, E. K. and Matre, R. 1996. Co-localization of the neonatal Fc gamma receptor and IgG in human placental term syncytiotrophoblasts. Eur. J. Immunol.26:1668.

Leach, J. L., Sedmak, D. D., Osborne, J. M., Rahill, B., Lairmore, M. D. and Anderson, C. L. 1996. Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal–fetal antibody transport. J. Immunol.157:3317.

Firan, M., Bawdon, R., Radu, C., Ober, R. J., Eaken, D., Antohe, F., Ghetie, V. and Ward, E. S. 2001. The MHC class I related receptor, FcRn, plays an essential role in the maternofetal transfer of gammaglobulin in humans. Int. Immunol.13:993.

Borvak, J., Richardson, J., Medesan, C., Antohe, F., Radu, C., Simionescu, M., Ghetie, V. and Ward, E. S. 1998. Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. Int. Immunol.10:1289.

Junghans, R. P. 1997. Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol. Res.16:29.

Kim, J. K., Firan, M., Radu, C. G., Kim, C. H., Ghetie, V. and Ward, E. S. 1999. Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn. Eur. J. Immunol.29:2819.

Martin, W. L., West, A. P. J., Gan, L. and Bjorkman, P. J. 2001. Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex: mechanism of pH dependent binding. Mol. Cell7:867.

Deisenhofer, J. 1981. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-Å resolution. Biochemistry20:2361.

Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C. 1991. Sequences of Proteins of Immunological Interest. US Department of Health and Human Services, Bethesda, MD.

Shields, R. L., Namenuk, A. K., Hong, K., Meng, Y. G., Rae, J., Briggs, J., Xie, D., Lai, J., Stadlen, A., Li, B., Fox, J. A. and Presta, L. G. 2001. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J. Biol. Chem.276:6591.

Raghavan, M., Bonagura, V. R., Morrison, S. L. and Bjorkman, P. J. 1995. Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. Biochemistry34:14649.

Medesan, C., Cianga, P., Mummert, M., Stanescu, D., Ghetie, V. and Ward, E. S. 1998. Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site. Eur. J. Immunol.28:2092.

Vaughn, D. E., Milburn, C. M., Penny, D. M., Martin, W. L., Johnson, J. L. and Bjorkman, P. J. 1997. Identification of critical IgG binding epitopes on the neonatal Fc receptor. J. Mol. Biol.274:597.

Foote, J. and Winter, G. 1992. Antibody framework residues affecting the conformation of the hypervariable loops. J. Mol. Biol.224:487.

Leslie, R. G. and Cohen, S. 1970. Chemical properties of guinea-pig immunoglobulins gamma-1 G, gamma-2 G and gamma M. Biochem. J.120:787.

Ey, P. L., Prowse, S. J. and Jenkin, C. R. 1978. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using Protein A–Sepharose. Immunochemistry15:429.

Campana, D., Janossy, G., Bofill, M., Trejdosiewicz, L. K., Ma, D., Hoffbrand, A. V., Mason, D. Y., Lebacq, A. M. and Forster, H. K. 1985. Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue. J. Immunol.134:1524.

Amit, A. G., Mariuzza, R. A., Phillips, S. E. and Poljak, R. J. 1986. Three-dimensional structure of an antigen–antibody complex at 2.8 Å resolution. Science233:747.

Schuck, P., Radu, C. G. and Ward, E. S. 1999. Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1. Mol. Immunol.36:1117.

Sanchez, L. M., Penny, D. M. and Bjorkman, P. J. 1999. Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand. Biochemistry38:9471.

Horton, R. M., Hunt, H. D., Ho, S. N., Pullen, J. K. and Pease, L. R. 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene77:61.

Ghetie, M. A., Podar, E. M., Ilgen, A., Gordon, B. E., Uhr, J. W. and Vitetta, E. S. 1997. Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells. Proc. Natl Acad. Sci. USA94:7509.

Fraker, P. J. and Speck, J. C. J. 1978. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. Biochem. Biophys. Res. Commun.80:849.

West, A. P. J. and Bjorkman, P. J. 2000. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. Biochemistry39:9698.

Kim, J. K., Tsen, M. F., Ghetie, V. and Ward, E. S. 1994. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. Eur. J. Immunol.24:2429.

Burmeister, W. P., Huber, A. H. and Bjorkman, P. J. 1994. Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature372:379.

Stefaner, I., Praetor, A. and Hunziker, W. 1999. Nonvectorial surface transport, endocytosis via a di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells. J. Biol. Chem.274:8998.

Wu, Z. and Simister, N. E. 2001. Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor. J. Biol. Chem.276:5240.

Sondermann, P., Huber, R., Oosthuizen, V. and Jacob, U. 2000. The 3.2-Å crystal structure of the human IgG1 Fc fragment–Fc gammaRIII complex. Nature406:267.

Maxwell, K. F., Powell, M. S., Hulett, M. D., Barton, P. A., McKenzie, I. F., Garrett, T. P. and Hogarth, P. M. 1999. Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa. Nat. Struct. Biol.6:437.

Simister, N. E. and Rees, A. R. 1985. Isolation and characterization of an Fc receptor from neonatal rat small intestine. Eur. J. Immunol.15:733.

Ahouse, J. J., Hagerman, C. L., Mittal, P., Gilbert, D. J., Copeland, N. G., Jenkins, N. A. and Simister, N. E. 1993. Mouse MHC class I-like Fc receptor encoded outside the MHC. J. Immunol.151:6076.

Kacskovics, I., Wu, Z., Simister, N. E., Frenyo, L. V. and Hammarstrom, L. 2000. Cloning and characterization of the bovine MHC class I-like Fc receptor. J. Immunol.164:1889.

Vaughn, D. E. and Bjorkman, P. J. 1997. High-affinity binding of the neonatal Fc receptor to its ligand requires receptor immobilization. Biochemistry36:9374.

Fersht, A. R., Shi, J-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y. and Winter, G. 1985. Hydrogen bonding and biological specificity analysed by protein engineering. Nature314:235.

Burmeister, W. P., Gastinel, L. N., Simister, N. E., Blum, M. L. and Bjorkman, P. J. 1994. Crystal structure at 2.2 Å resolution of the MHC-related neonatal Fc receptor. Nature372:336.