Inflammation
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Bovine neutrophils recruited by endotoxin to a teat cistern continuously produce oxygen radicals and show increased phagocytosis and extracellular chemiluminescence
Inflammation - Tập 16 - Trang 117-133 - 1992
Bovine neutrophils were harvested from a teat cistern following endotoxin infusion and were compared with blood neutrophils by measurements of chemiluminescent and phagocytic activity towards C3-and IgG-opsonized and unopsonized yeast particles. Both phagocytosis and luminol-dependent chemiluminescence elicited by all three particles were enhanced in the teat cells. The increase in the luminoldepe......
Inhibition of lysosomal enzyme release from rat leukocytes by auranofin
Inflammation - Tập 2 - Trang 131-142 - 1977
Auranofin (SK&F D-39162), a new antiarthritic gold compound reported to be orally effective in animal (adjuvant rat) and human (rheumatoid) arthritic conditions, is a potent in vitro inhibitor of the release of lysosomal enzymes from phagocytizing rat leukocytes. Auranofin, at micromolar concentrations (1–10μM), produced a dose-dependent reduction in extra-cellular levels of lysosomal enzyme marke......
Occupancy of adenosine receptors on human neutrophils inhibits respiratory burst stimulated by ingestion of complement-coated particles and occupancy of chemoattractant but not Fc receptors
Inflammation - Tập 13 - Trang 591-599 - 1989
Chemoattractants are generated at inflammatory loci that not only induce neutrophils (PMNs) to leave the vasculature but also stimulate PMNs to release potentially toxic agents (e.g., H2O2, O
2
−
or OH). We have recently demonstrated that endothelium releases adenosine which, when bound to a specific receptor on the PMN surface, inhibits release......
Activation of Transcription Factors and IL-8 Expression in Neutrophils Stimulated with Lipopolysaccharide from Porphyromonas gingivalis
Inflammation - Tập 22 - Trang 253-267 - 1998
DNA binding activity of NF-κB and AP-1 were examined in neutrophils stimulated with LPS purified from P. gingivalis, a major pathogenic bacteria of periodontitis lesion. Porphyromonas gingivalis LPS enhanced the activity reaching a peak at a concentration of 500 ng/ml in the absence of serum. The NF-κB activation stimulated with 10 ng/ml of P. gingivalis LPS was suppressed approximately 44% by tre......
Expression of Human Secretory Group IIA Phospholipase A2 is Associated with Reduced Concentrations of Plasma Cholesterol in Transgenic Mice
Inflammation - Tập 24 - Trang 227-237 - 2000
It is well known that acute and chronic inflammatory reactions are accompanied by markedly decreased concentrations of plasma total cholesterol. However, the mechanisms underlying this hypocholesterolemia are not yet completely understood. To explore the question of whether an increased serum activity of secretory group IIA phospholipase A2 (sPLA2) may contribute to the development of hypocholeste......
Role of resident macrophages in canatoxin-induced in vivo neutrophil migration
Inflammation - Tập 16 - Trang 1-12 - 1992
Canatoxin (Cntx), a toxic protein purified fromCanavalia ensiformis seeds, was shown to have lipoxygenase-mediated effects either in vivo or in vitro. Data here show that Cntx induced a dose-dependent migration of neutrophils and mononuclear cells when injected into rat peritoneal cavities. Furthermore, Cntx was able to induce neutrophil migration into pleural cavities and into air pouches. These ......
Effect of leukocyte hydrolases on bacteria xvi
Inflammation - Tập 6 - Trang 269-284 - 1982
The mechanisms involved in the activation of autolytic enzymes inStaphylococcus aureus, by leukocyte extracts, cationic proteins, phospholipase A2, amines, and membrane-damaging agents was studied in a resting cell system as well as by growing staphylococci. The bacteria were labeled with [14C]N-acetylglucosamine and were subjected to a variety of agents either in 0.1 M acetate buffer, pH 5.0, or ......
Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis
Inflammation - Tập 41 - Trang 104-113 - 2017
Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats were pretreated with simvastatin (0.2 μg/g) for 1 week before cecal ligation and pu......
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study
Inflammation - Tập 46 Số 2 - Trang 655-678 - 2023
Different Expression of MicroRNA-146a in Peripheral Blood CD4+ T Cells and Lesions of Oral Lichen Planus
Inflammation - Tập 39 - Trang 860-866 - 2016
Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease of unknown etiology. Recent increasing evidence indicates that microRNA-146a (miR-146a) plays a vital role in inflammatory diseases and T cell regulation. This study aimed to investigate the expression of miRNA-146a in peripheral blood CD4+ T cells and local OLP lesions and to evaluate its relationship with clinical ......
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