Protein O Glycosylation Regulates Activation of Hepatic Stellate Cells

Inflammation - Tập 36 Số 6 - Trang 1248-1252 - 2013
Fan, Xiao1,2, Chuan, Song1,2, Hongshan, Wei1,2
1Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
2Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, China

Tóm tắt

It was reported that O glycosylation is associated with hepatic stellate cell activation and regulates collagen expression. In this study, we aimed to investigate the effect of O glycosylation on the activation of human hepatic stellate cells. We found that the inhibitor of O glycosylation, benzyl-α-GalNAc (2 and 4 mM), could significantly inhibit cells proliferation in a dose-dependent manner. Moreover, benzyl-α-GalNAc decreased the expressions of α-smooth muscle actin, collagen I, and collagen III. The results indicate that O glycosylation is involved in the activation of hepatic stellate cells.

Tài liệu tham khảo

citation_journal_title=The Journal of Clinical Investigation; citation_title=Liver fibrosis; citation_author=R Bataller, DA Brenner; citation_volume=115; citation_issue=2; citation_publication_date=2005; citation_pages=209-218; citation_id=CR1 citation_journal_title=Journal of Gastroenterology and Hepatology; citation_title=Molecular mechanisms of hepatic fibrogenesis; citation_author=CJ Parsons, M Takashima, RA Rippe; citation_volume=22; citation_issue=1; citation_publication_date=2007; citation_pages=S79-S84; citation_doi=10.1111/j.1440-1746.2006.04659.x; citation_id=CR2 citation_journal_title=Gastroenterología y Hepatología; citation_title=Hepatic stellate cells: Its role in normal and pathological conditions; citation_author=M Sarem, R Znaidak, M Macías, R Rey; citation_volume=29; citation_issue=2; citation_publication_date=2006; citation_pages=93-101; citation_doi=10.1157/13083906; citation_id=CR3 citation_journal_title=Journal of Gastroenterology; citation_title=Hepatic stellate cells: A target for the treatment of liver fibrosis; citation_author=J Wu, MA Zern; citation_volume=35; citation_issue=9; citation_publication_date=2000; citation_pages=665-672; citation_doi=10.1007/s005350070045; citation_id=CR4 citation_journal_title=Journal of Gastroenterology and Hepatology; citation_title=Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy; citation_author=D Li, SL Friedman; citation_volume=14; citation_issue=7; citation_publication_date=1999; citation_pages=618-633; citation_doi=10.1046/j.1440-1746.1999.01928.x; citation_id=CR5 citation_journal_title=Biochimica et Biophysica Acta; citation_title=On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database; citation_author=R Apweiler, H Hermjakob, N Sharon; citation_volume=1473; citation_publication_date=1999; citation_pages=4-8; citation_doi=10.1016/S0304-4165(99)00165-8; citation_id=CR6 citation_journal_title=Clinical Cancer Research; citation_title=HDL of patients with type 2 diabetes mellitus elevates the capability of promoting breast cancer metastasis; citation_author=B Pan, H Ren, Y He, X Lv, Y Ma, J Li, L Huang, B Yu, J Kong, C Niu, Y Zhang, WB Sun, L Zheng; citation_volume=18; citation_issue=5; citation_publication_date=2012; citation_pages=1246-1256; citation_doi=10.1158/1078-0432.CCR-11-0817; citation_id=CR7 citation_journal_title=American Journal of Clinical Nutrition; citation_title=Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis; citation_author=Y Yamamoto, Y Hiasa, H Murakami, Y Ikeda, H Yamanishi, M Abe, B Matsuura, M Onji; citation_volume=96; citation_issue=1; citation_publication_date=2012; citation_pages=90-101; citation_doi=10.3945/ajcn.111.033084; citation_id=CR8 citation_journal_title=PLoS One; citation_title=Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody; citation_author=JG Kim, MJ Kang, YK Yoon, HP Kim, J Park, SH Song, SW Han, JW Park, GH Kang, KW Kang, DY Oh, SA Im, YJ Bang, EC Yi, TY Kim; citation_volume=7; citation_issue=3; citation_publication_date=2012; citation_pages=e33322; citation_doi=10.1371/journal.pone.0033322; citation_id=CR9 citation_journal_title=Communication Integration Biology; citation_title=Novel roles for GlcNAc in cell signaling; citation_author=S Naseem, SM Parrino, DM Buenten, JB Konopka; citation_volume=5; citation_issue=2; citation_publication_date=2012; citation_pages=156-159; citation_doi=10.4161/cib.19034; citation_id=CR10 citation_journal_title=Current Opinion in Structural Biology; citation_title=Molecular mechanisms of O-GlcNAcylation; citation_author=R Hurtado-Guerrero, HC Dorfmueller, DM Aalten; citation_volume=18; citation_issue=5; citation_publication_date=2008; citation_pages=551-557; citation_doi=10.1016/j.sbi.2008.09.005; citation_id=CR11 citation_journal_title=Journal of Pharmacological Sciences; citation_title=Protein O-glycosylation induces collagen expression and contributes to diabeticcardiomyopathy in rat cardiac fibroblasts; citation_author=Y Kohda, M Kanematsu, T Kono, F Terasaki, T Tanaka; citation_volume=111; citation_issue=4; citation_publication_date=2009; citation_pages=446-450; citation_doi=10.1254/jphs.09236SC; citation_id=CR12 citation_journal_title=Journal of Proteomics; citation_title=Alteration of protein glycosylation in human hepatic stellate cells activated with transforming growth factor-β1; citation_author=Y Qin, Y Zhong, L Dang, M Zhu, H Yu, W Chen, J Cui, H Bian, Z Li; citation_volume=75; citation_issue=13; citation_publication_date=2012; citation_pages=4114-4123; citation_doi=10.1016/j.jprot.2012.05.040; citation_id=CR13 citation_journal_title=Glycobiology; citation_title=Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis; citation_author=B Xia, JA Royall, G Damera, GP Sachdev, RD Cummings; citation_volume=15; citation_issue=8; citation_publication_date=2005; citation_pages=747-775; citation_doi=10.1093/glycob/cwi061; citation_id=CR14 citation_journal_title=Biochimica et Biophysica Acta; citation_title=O-GlcNAc and the control of gene expression; citation_author=FJ Comer, GW Hart; citation_volume=1473; citation_publication_date=1999; citation_pages=161-171; citation_doi=10.1016/S0304-4165(99)00176-2; citation_id=CR15 citation_journal_title=FEBS Letters; citation_title=O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene; citation_author=M Kuo, V Zilberfarb, N Gangneux, N Christeff, T Issad; citation_volume=582; citation_publication_date=2008; citation_pages=829-834; citation_doi=10.1016/j.febslet.2008.02.010; citation_id=CR16 citation_journal_title=Archives of Biochemistry and Biophysics; citation_title=Aberrant O-glycosylation in the collagenous domain of pro alpha2(I) procollagen subunits synthesized by chemically transformed hamster fibroblasts; citation_author=U Ramachandran, B Peterkofsky; citation_volume=342; citation_issue=1; citation_publication_date=1997; citation_pages=29-37; citation_doi=10.1006/abbi.1997.0101; citation_id=CR17 citation_journal_title=Physiological Reviews; citation_title=Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver; citation_author=SL Friedman; citation_volume=88; citation_publication_date=2008; citation_pages=125-172; citation_doi=10.1152/physrev.00013.2007; citation_id=CR18 citation_journal_title=Hepatology Research; citation_title=Evolution of hepatic fibrosis research; citation_author=N Kawada; citation_volume=41; citation_issue=3; citation_publication_date=2011; citation_pages=199-208; citation_doi=10.1111/j.1872-034X.2011.00776.x; citation_id=CR19