Oncogenic viruses associated with vulva cancer in HIV-1 patients in BotswanaInfectious Agents and Cancer - Tập 9 - Trang 1-9 - 2014
Kenneth O Simbiri, Hem C Jha, Mukendi K Kayembe, Carrie Kovarik, Erle S Robertson
Oncoviruses such as HPV, KSHV, and EBV have been reported in patients with HIV infection and AIDS. How oncovirus-associated cancers rise in AIDS patients has not been fully established. The purpose of our study was to identify the viral agents in vulvar cancer and to assess their contribution to pathogenesis. We retrospectively identified a total of 13 vulva tissue samples from HIV-1 positive and ...... hiện toàn bộ
The relationship between previous pulmonary tuberculosis and risk of lung cancer in the futureInfectious Agents and Cancer - Tập 17 - Trang 1-12 - 2022
Yongwei Qin, Yujie Chen, Jinliang Chen, Kuang Xu, Feifan Xu, Jiahai Shi
Various investigations have expanded the views that tuberculosis is an important risk factor for lung cancer occurrence. Lung cancer originates from chronic inflammation and infection. It is becoming clearer that Mycobacterium tuberculosis (M.tb) in tuberculosis patients meticulously schemes multiple mechanisms to induce tumor formation and is indispensable to participate in the occurrence of lung...... hiện toàn bộ
High-risk human papillomavirus genotype distribution among women living with HIV; implication for cervical cancer prevention in a resource limited settingInfectious Agents and Cancer -
Patrick Kafui Akakpo, Sebastian Ken‐Amoah, Nancy Innocentia Ebu Enyan, Elizabeth Agyare, Emmanuel Salia, Ibrahim Baidoo, Leonard Derkyi-Kwarteng, Matthew Asare, George Adjei, Stephen Ayisi Addo, Dorcas Obiri‐Yeboah
Abstract
Background
For women living with HIV (WLHIV), the burden of persistent HPV infection, cervical pre-cancerous lesions and cancer have been demonstrated to be higher than among HIV-negative women. As Ghana and other lower-middle-income countries (LMIC) work toward developing national cervical...... hiện toàn bộ
Evaluation of an isothermal amplification HPV detection assay for primary cervical cancer screeningInfectious Agents and Cancer - - 2020
Wei Zhang, Hui Du, Xia Huang, Chun Wang, Xiaohui Duan, Yan Liu, Bin Shu, Xinfeng Qu, Lihui Wei, Mark Schiffman, Jerome L. Belinson, Ruifang Wu
Abstract
Objective
The aim of this research was to evaluate independently the performance of a new isothermal amplification assay for cervical cancer screening compared to two previously validated PCR-based assays and histologic endpoints.
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Viral non-coding RNA inhibits HNF4α expression in HCV associated hepatocellular carcinomaInfectious Agents and Cancer - Tập 10 - Trang 1-9 - 2015
Zhao Wang, Kristin Ceniccola, Liliana Florea, Bi-Dar Wang, Norman H. Lee, Ajit Kumar
Hepatitis C virus (HCV) infection is an established cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC); however, it is unclear if the virus plays a direct role in the development of HCC. Hepatocyte nuclear factor 4α (HNF4α) is critical determinant of epithelial architecture and hepatic development; depletion of HNF4α is correlated with oncogenic transformation. We explored th...... hiện toàn bộ
Construction and immune effect of an HPV16/18/58 trivalent therapeutic adenovirus vector vaccineInfectious Agents and Cancer - Tập 17 - Trang 1-19 - 2022
Bing Wan, Lu Qin, Weihong Ma, He Wang
This study aims to prepare candidate vaccines for cervical cancer immunotherapy by inserting the fused genes of human papillomavirus (HPV)16/18/58 mE6E7 lacking transforming activity into an adenovirus vector and to verify its efficiency in model mice with tumor expressing the associated HPV genes. The E6/E7 genes of HPV16/18/58 were point-mutated to abolish their transforming activity, and adenov...... hiện toàn bộ