Immunity & Ageing
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation
Immunity & Ageing - Tập 16 - Trang 1-13 - 2019
Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG. Positive staining for IgG wa...... hiện toàn bộ
Thymic function and survival at advance ages in nursing home residents from Southern ItalyAbstract
Background
Immunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the immunosenescence process is the thymic involution and, consequently, the decreased numbers and functions of T cells. Since thymic involution results in... ... hiện toàn bộ
Immunity & Ageing -
Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
Immunity & Ageing - Tập 9 - Trang 1-8 - 2012
End-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study was to investigate whether uremia was able to induce premature ageing of the T cell compartment. For this purpose, we examined the degree of premature immunological T cell ageing by examining ...... hiện toàn bộ
Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults
Immunity & Ageing - Tập 16 Số 1 - 2019
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Immunity & Ageing - Tập 20 - Trang 1-11 - 2023
Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have reached clinical practice. Recently, circular RNAs have emerged as new non-coding RNAs. Their regulatory role together with their high stability in biofluid...... hiện toàn bộ
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability
Immunity & Ageing - Tập 21 - Trang 1-13 - 2024
Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surge in recent years. The unidentified etiology poses limitations to the development of effective therapeutic interventions for this condition. Helicobacter pylori (H. pylori) infection has affe...... hiện toàn bộ
Emergence of T cell immunosenescence in diabetic chronic kidney diseaseAbstract
Background
Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develo... ... hiện toàn bộ
Immunity & Ageing - - 2020
Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults
Immunity & Ageing - Tập 5 - Trang 1-9 - 2008
Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection with human Cytomegalovirus (CMV) is contributing to and accelerating immunosenescence. However, latent CMV infection and reactivation usually does not cause overt symptoms in immunocompetent eld...... hiện toàn bộ
Erratum to: Early dysregulation of the memory CD8+T cell repertoire leads to compromised immune responses to secondary viral infection in the aged
Immunity & Ageing - Tập 10 - Trang 1-1 - 2013
Tổng số: 394
- 1
- 2
- 3
- 4
- 5
- 6
- 10