Immunity & Ageing

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Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice
Immunity & Ageing - Tập 16 - Trang 1-17 - 2019
Benthe van der Lugt, Adriaan A. van Beek, Steven Aalvink, Ben Meijer, Bruno Sovran, Wilbert P. Vermeij, Renata M. C. Brandt, Willem M. de Vos, Huub F. J. Savelkoul, Wilma T. Steegenga, Clara Belzer
The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory effects. The abundance of A. muciniphila is associated with a healthy gut in early mid- and later life. However, the effects of A. muciniphila on a decline in intestinal ...... hiện toàn bộ
Mechanisms of immunosenescence
Immunity & Ageing - Tập 6 Số 1 - 2009
Calogero Caruso, Silvio Buffa, Giuseppina Candore, Giuseppina Colonna‐Romano, Deborah K. Dunn‐Walters, David Kipling, Graham Pawelec
pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients
Immunity & Ageing - Tập 14 - Trang 1-14 - 2017
Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan, Michiel G. H. Betjes
Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate diverse cellular programs by transferring extracellular signals into an intracellular response. T cell receptor (TCR)-induced phosphorylation of ERK (pERK) may show an a...... hiện toàn bộ
Human endogenous retroviruses and ageing
Immunity & Ageing - Tập 18 - Trang 1-2 - 2021
Mikko Hurme, Graham Pawelec
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies
Immunity & Ageing - Tập 19 - Trang 1-2 - 2022
Gemma Manich, Elisabet Augé, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana, Carme Pelegrí
Effects of human Toll-like receptor 1 polymorphisms on ageing
Immunity & Ageing - Tập 10 Số 1 - 2013
Peter Uciechowski, Eva Maria Oellig, Erminia Mariani, Marco Malavolta, Eugenio Mocchegiani, Lothar Rink
Abstract Background Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases. Toll-like receptors (TLR) recognize pathogenic structures and are important in the immune response to infections and ...... hiện toàn bộ
12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial
Immunity & Ageing - Tập 20 - Trang 1-14 - 2023
Tim Konstantin Boßlau, Paulina Wasserfurth, Thomas Reichel, Christopher Weyh, Jana Palmowski, Josefine Nebl, Niklas Joisten, Sergen Belen, Alexander Schenk, Andreas Hahn, Philipp Zimmer, Karsten Krüger
Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption of the kynurenine (KYN) pathway are associated with chronic inflammation and the development of insulin resistance. In this study the aim was to investigate the effects of 12-week combined strength and endurance exercise on CD8+ T-cell differentiation and KYN pathway metabolite...... hiện toàn bộ
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
Immunity & Ageing - Tập 20 - Trang 1-15 - 2023
Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders, Martha A. Alexander-Miller
Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses. We followed older adults in a retirement facility with longitudinal clinical and serological samples from the first Moderna mRNA-1273 vaccine dose starting in February 2021 through their 3rd (booster)...... hiện toàn bộ
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
Immunity & Ageing - Tập 18 - Trang 1-7 - 2021
Cecilia Söderberg-Nauclér
The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are ...... hiện toàn bộ
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Immunity & Ageing - Tập 20 - Trang 1-10 - 2023
Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki, Graham Pawelec, Agustín Lage
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell ...... hiện toàn bộ
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