Hormones and Cancer
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The activity of cuproptosis pathway calculated by AUCell algorithm was employed to construct cuproptosis landscape in lung adenocarcinoma
Hormones and Cancer - Tập 14 - Trang 1-18 - 2023
Cuproptosis is a recently described copper-dependent cell death pathway. Consequently, there are still few studies on lung adenocarcinoma (LUAD)-related cuproptosis, and we aimed to deepen in this matter. In this study, data from 503 patients with lung cancer from the TCGA-LUAD cohort data collection and 11 LUAD single-cells from GSE131907 as well as from 10 genes associated with cuproptosis were ......
Mouse Prostate Cancer Cell Lines Established from Primary and Postcastration Recurrent Tumors
Hormones and Cancer - Tập 1 - Trang 44-54 - 2010
The clinical course of prostate cancer is grouped into two broad phases. The first phase, which is the growth of the androgen-dependent cancer (AD-Ca), responds well to androgen depletion treatment while the second phase that could be termed as androgen-depletion-independent cancer (ADI-Ca) does not. We used two separate prostate tumors, one AD-Ca and one ADI-Ca from the conditional Pten deletion ......
Incidence and risk factors of hypertension therapy in Australian cancer patients treated with vascular signalling pathway inhibitors
Hormones and Cancer - Tập 13 - Trang 1-10 - 2022
Clinical trials report systemic hypertension is an adverse effect of vascular signalling pathway inhibitor (VSPi) use. There are limited data from routine clinical practice. We aimed to estimate the real-world incidence and risk factors of new-onset and aggravated hypertension for cancer patients dispensed VSPi in whole-of-population Australian setting. We used dispensing records for a 10% random ......
New fluorobenzamidine exerts antitumor activity against breast cancer in mice via pro-apoptotic activity
Hormones and Cancer - Tập 13 - Trang 1-14 - 2022
Breast cancer is one of the leading causes of cancer-related morbidities. The present study aimed to evaluate the efficacy of bithiophene-fluorobenzamidine (BFB) against breast cancer induced by 7,12-dimethylbenz(a)anthracene (DMBA) in female Swiss mice and reveal the underlining mechanisms. The mice were randomly divided into five groups; control, BFB-treated group, DMBA-treated group, and the la......
Involvement of Aryl Hydrocarbon Receptor in l-Kynurenine-Mediated Parathyroid Hormone–Related Peptide Expression
Hormones and Cancer - Tập 10 - Trang 89-96 - 2019
Parathyroid hormone-related peptide (PTHrP), produced by specific cancers such as lung cancer, profoundly influences the formation of bone metastatic lesions via the “vicious cycle” of tumor growth and bone resorption. The changes in gene expression regulated by the abnormal microenvironment components play key roles in maintaining the biological characteristics of cells, such as the organotropism......
Radiation and immune checkpoint inhibitor-mediated pneumonitis risk stratification in patients with locally advanced non-small cell lung cancer: role of functional lung radiomics?
Hormones and Cancer - Tập 13 - Trang 1-12 - 2022
Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI) therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary toxicity at higher rates than historical reports. Identifying biomarkers beyond conventional clinical factors and radiation dosimetry is especially relevant in the modern cancer immunotherapy era. We investigated the role of novel functional ......
Prognostic significance of tumor infiltrating lymphocytes on first-line pembrolizumab efficacy in advanced non-small cell lung cancer
Hormones and Cancer - Tập 14 - Trang 1-13 - 2023
Tumor-infiltrating lymphocytes (TILs) in the tumor and stroma are expected to accurately predict the efficacy of programmed death-1 (PD-1) blockade therapy. However, little is known about the prognostic significance of TILs in first-line PD-1 therapy. We assessed TILs in patients with advanced or metastatic non-small cell lung cancer (NSCLC) treated with pembrolizumab in the palliative setting. Mu......
Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
Hormones and Cancer - Tập 14 - Trang 1-10 - 2023
To establish a machine learning-based radiomics model to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes, thereby achieving accurate preoperative classification. A retrospective analysis was conducted on MRI T1WI-enhanced images of 105 patients with glioma and 172 patients with solitary brain metastasis from lung cancer, which were confirmed pathologica......
BRAF-Oncogene-Induced Senescence and the Role of Thyroid-Stimulating Hormone Signaling in the Progression of Papillary Thyroid Carcinoma
Hormones and Cancer - Tập 9 - Trang 1-11 - 2017
Oncogene-induced senescence (OIS) explains the phenomenon of cellular senescence triggered by the action of oncogenes. It is a mechanism adopted by a cell to inhibit progression of benign tumors into malignancy, occurs in premalignant lesions, and is almost never present in malignant lesions. BRAF mutations occur in about 40–45% of all papillary thyroid carcinomas (PTCs) and of which 99.7% is the ......
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