Sarcomas of fat and bone: a case report
Tóm tắt
Osteosarcomas are the most common primary malignant bone tumors and are classified by the WHO into several intramedullary and surface subtypes. One of these is the rare parosteal osteosarcoma. Liposarcomas are the second most common soft tissue sarcoma and are classified into several types ranging from intermediate to high grade tumors. In one of our recent patients we found an unusual combination of a parosteal osteosarcoma and a large fatty component, which fluorescence-in-situ-hybridization revealed as liposarcoma. Radiologists, pathologists, and surgeons should consider the possibility of bone and soft tissue malignancies consisting of different components, as this may be of paramount importance for oncologically complete resection.
Tài liệu tham khảo
WHO Classification of Tumours. Soft tissue and bone tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2020.
Harper K, Sathiadoss P, Saifuddin A, Sheikh A. A review of imaging of surface sarcomas of bone. Skeletal Radiol. 2021;50(1):9–28.
Franceschini N, Lam SW, Cleton-Jansen A-M, Bovée JVMG. What’s new in bone forming tumours of the skeleton? Virchows Arch. 2020;476(1):147–57.
Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM. Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol. 2009;62(12):1127–35.
Sirvent N, Coindre J-M, Maire G, Hostein I, Keslair F, Guillou L, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.
Kumar VS, Barwar N, Khan SA. Surface osteosarcomas: diagnosis, treatment and outcome. Indian J Orthop. 2014;48(3):255–61.
Barnard L. Primary liposarcoma of bone. Arch Surg. 1934;29(4):560.
Tiemeier GL, Brown JM, Pratap SE, McCarthy C, Kastrenopoulou A, Bradley K, et al. Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour. Clin Sarcoma Res. 2018;8:2.
Hamlat A, Saikali S, Gueye E-M, Le Strat A, Carsin-Nicol B, Brassier G. Primary liposarcoma of the thoracic spine: case report. Eur Spine J. 2005;14(6):613–8.
Yamashita K, Kohashi K, Yamada Y, Ishii T, Nishida Y, Urakawa H, et al. Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. Histopathology. 2018;72(5):729–38.
Li N, Li L, La Tegola L, Ding Y, Liu W, Niu X, et al. Parosteal osteosarcoma with focal fatty metaplasia: a case report. Radiol Case Rep. 2018;14(2):200–3.
Larousserie F, Chen X, Ding Y, Kreshak J, Cocchi S, Huang X, et al. Parosteal osteoliposarcoma: a new bone tumor (from imaging to immunophenotype). Eur J Radiol. 2013;82(12):2149–53.
Sohier P, Rodrigues M, Anract P, Feydy A, Larousserie F. Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. Skeletal Radiol. 2021;50(1):243–8.