Hematology. American Society of Hematology. Education Program
SCIE-ISI SCOPUS (2001-2024)
1520-4383
1520-4391
Mỹ
Cơ quản chủ quản: AMER SOC HEMATOLOGY , American Society of Hematology
Lĩnh vực:
Hematology
Các bài báo tiêu biểu
The 2008 WHO classification of lymphomas: implications for clinical practice and translational research
Tập 2009 Số 1 - Trang 523-531 - 2009
AbstractThe 4th edition of the WHO Classification of Tumours of Haematopoietic
and Lymphoid Tissues published in 2008 builds upon the success of the 2001 3rd
edition; new entities are defined, and solutions for problematic categories are
sought. Recent studies have drawn attention to the biological overlap between
classical Hodgkin lymphoma (CHL) and diffuse large B-cell lymphomas (DLBCL).
Similar...
Update on Cobalamin, Folate, and Homocysteine
Tập 2003 Số 1 - Trang 62-81 - 2003
Abstract Three topics affecting cobalamin, folate, and homocysteine that have
generated interest, activity, and advances in recent years are discussed. These
are: (I) the application of an expanded variety of tools to the diagnosis of
cobalamin deficiency, and how these affect and are affected by our current
understanding of deficiency; (II) the nature of the interaction between
homocysteine and v...
Recent Advances in Thrombotic Thrombocytopenic Purpura
Tập 2004 Số 1 - Trang 407-423 - 2004
Abstract Thrombotic thrombocytopenic purpura (TTP) is characterized by
microangiopathic hemolytic anemia and thrombocytopenia, accompanied by
microvascular thrombosis that causes variable degrees of tissue ischemia and
infarction. Intravascular coagulation is not a prominent feature of the
disorder. Plasma exchange can induce remissions in approximately 80% of patients
with idiopathic TTP, but pat...
Deep Venous Thrombosis
Tập 2004 Số 1 - Trang 439-456 - 2004
Abstract Venous thromboembolism (VTE), manifested as either deep venous
thrombosis (DVT) or pulmonary embolism (PE), is an extremely common medical
problem, occurring either in isolation or as a complication of other diseases or
procedures. Yet, despite its frequency, much remains to be learned regarding the
pathogenic mechanisms that initiate VTE, about tailoring its treatment to the
individual w...
Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem
Tập 2007 Số 1 - Trang 91-96 - 2007
AbstractPatients with sickle cell disease (SCD) exhibit high plasma levels of
markers of thrombin generation, depletion of natural anticoagulant proteins,
abnormal activation of the fibrinolytic system, and increased tissue factor
expression, even in the non-crisis steady state. In addition, platelets and
other cellular elements are chronically activated in the non-crisis state.
Despite an abundan...
Acute Myeloid Leukemia
Tập 2004 Số 1 - Trang 98-117 - 2004
AbstractAdvances in our understanding of the pathophysiology of acute myeloid
leukemia (AML) have not yet led to major improvements in disease-free and
overall survival of adults with this disease. Only about one-third of those
between ages 18–60 who are diagnosed with AML can be cured; disease-free
survival is rare and current therapy devastating in older adults. In this
chapter, challenges in th...
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Tập 2003 Số 1 - Trang 497-519 - 2003
AbstractAcquired abnormalities in platelets, endothelium, and their interaction
occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the
antiphospholipid syndrome. Although of distinct pathogeneses, these three
disorders have several clinical features in common, including thrombocytopenia
and the potential for life- and limb-threatening thrombotic events, ranging from
microvascular ...
Chronic Myeloproliferative Disorders
Tập 2003 Số 1 - Trang 200-224 - 2003
AbstractThe Philadelphia chromosome-negative chronic myeloproliferative
disorders (CMPD), polycythemia vera (PV), essential thrombocythemia (ET) and
chronic idiopathic myelofibrosis (IMF), have overlapping clinical features but
exhibit different natural histories and different therapeutic requirements.
Phenotypic mimicry amongst these disorders and between them and nonclonal
hematopoietic disorder...
The Anemia of Inflammation/Malignancy: Mechanisms and Management
Tập 2008 Số 1 - Trang 159-165 - 2008
AbstractAnemia is a common complication in patients with inflammatory diseases
of many kinds, including cancer. The mechanisms that have captured the most
attention include cytokine-mediated changes in both the production of and the
response to erythropoietin (Epo), as well as important alterations in iron
metabolism. The last is brought about by the relatively recently recognized
peptide hormone,...
Single-dose intravenous iron for iron deficiency: a new paradigm
Tập 2016 Số 1 - Trang 57-66 - 2016
AbstractIron-deficiency anemia is the most common hematologic problem in the
world. Although oral iron is often viewed as front-line therapy, extensive
published evidence has accumulated that IV iron is superior, in both efficacy
and safety, to oral iron in many clinical situations and should be introduced
much sooner in the treatment paradigm of iron-deficient patients. In this
chapter, we will r...