Update on Cobalamin, Folate, and Homocysteine Tập 2003 Số 1 - Trang 62-81 - 2003
Ralph Carmel, Ralph Green, David S. Rosenblatt, David Watkins
Abstract
Three topics affecting cobalamin, folate, and homocysteine that have generated interest, activity, and advances in recent years are discussed. These are: (I) the application of an expanded variety of tools to the diagnosis of cobalamin deficiency, and how these affect and are affected by our current understanding of deficiency; (II) the natu...... hiện toàn bộ Recent Advances in Thrombotic Thrombocytopenic Purpura Tập 2004 Số 1 - Trang 407-423 - 2004
J. Evan Sadler, Joel L. Moake, Toshiyuki Miyata, James N. George
Abstract
Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, accompanied by microvascular thrombosis that causes variable degrees of tissue ischemia and infarction. Intravascular coagulation is not a prominent feature of the disorder. Plasma exchange can induce remissions in approximat...... hiện toàn bộ Deep Venous Thrombosis Tập 2004 Số 1 - Trang 439-456 - 2004
José A. López, Clive Kearon, Agnes Y.Y. Lee
Abstract
Venous thromboembolism (VTE), manifested as either deep venous thrombosis (DVT) or pulmonary embolism (PE), is an extremely common medical problem, occurring either in isolation or as a complication of other diseases or procedures. Yet, despite its frequency, much remains to be learned regarding the pathogenic mechanisms that initiate VTE, a...... hiện toàn bộ Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem Tập 2007 Số 1 - Trang 91-96 - 2007
Kenneth I. Ataga, Nigel S. Key
AbstractPatients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic system, and increased tissue factor expression, even in the non-crisis steady state. In addition, platelets and other cellular elements are chronically activated in the non...... hiện toàn bộ Acute Myeloid Leukemia Tập 2004 Số 1 - Trang 98-117 - 2004
Richard M. Stone, Margaret O’Donnell, Mikkael A. Sekeres
AbstractAdvances in our understanding of the pathophysiology of acute myeloid leukemia (AML) have not yet led to major improvements in disease-free and overall survival of adults with this disease. Only about one-third of those between ages 18–60 who are diagnosed with AML can be cured; disease-free survival is rare and current therapy devastating in older adults. ...... hiện toàn bộ Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome Tập 2003 Số 1 - Trang 497-519 - 2003
Theodore E. Warkentin, William C. Aird, Jacob H. Rand
AbstractAcquired abnormalities in platelets, endothelium, and their interaction occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome. Although of distinct pathogeneses, these three disorders have several clinical features in common, including thrombocytopenia and the potential for life- and limb-threatening thrombotic ev...... hiện toàn bộ Chronic Myeloproliferative Disorders Tập 2003 Số 1 - Trang 200-224 - 2003
Jerry L. Spivak, Giovanni Barosi, Gianni Tognoni, Tiziano Barbui, Guido Finazzi, Roberto Marchioli, Monia Marchetti
AbstractThe Philadelphia chromosome-negative chronic myeloproliferative disorders (CMPD), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (IMF), have overlapping clinical features but exhibit different natural histories and different therapeutic requirements. Phenotypic mimicry amongst these disorders and between them and...... hiện toàn bộ The Anemia of Inflammation/Malignancy: Mechanisms and Management Tập 2008 Số 1 - Trang 159-165 - 2008
John W. Adamson
AbstractAnemia is a common complication in patients with inflammatory diseases of many kinds, including cancer. The mechanisms that have captured the most attention include cytokine-mediated changes in both the production of and the response to erythropoietin (Epo), as well as important alterations in iron metabolism. The last is brought about by the relatively rec...... hiện toàn bộ Single-dose intravenous iron for iron deficiency: a new paradigm Tập 2016 Số 1 - Trang 57-66 - 2016
Michael Auerbach, Thomas G. DeLoughery
AbstractIron-deficiency anemia is the most common hematologic problem in the world. Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient pat...... hiện toàn bộ