Hematology. American Society of Hematology. Education Program
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Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem
Hematology. American Society of Hematology. Education Program - Tập 2007 Số 1 - Trang 91-96 - 2007
AbstractPatients with sickle cell disease (SCD) exhibit high plasma levels of
markers of thrombin generation, depletion of natural anticoagulant proteins,
abnormal activation of the fibrinolytic system, and increased tissue factor
expression, even in the non-crisis steady state. In addition, platelets and
other cellular elements are chronically activated in the non-crisis state.
Despite an abundan...
Antithrombotic therapy: triple therapy or triple threat?
Hematology. American Society of Hematology. Education Program - Tập 2012 Số 1 - Trang 547-552 - 2012
Abstract Antithrombotic therapy plays an essential role in the management of
some of the most common and morbid medical conditions. Triple oral
antithrombotic therapy (TOAT) is defined as the administration of both
therapeutic oral anticoagulation (OAC) and dual antiplatelet therapy (DAPT) to
patients with indications for both treatments. The current societal guidelines
regarding TOAT are derived ...
Single-dose intravenous iron for iron deficiency: a new paradigm
Hematology. American Society of Hematology. Education Program - Tập 2016 Số 1 - Trang 57-66 - 2016
AbstractIron-deficiency anemia is the most common hematologic problem in the
world. Although oral iron is often viewed as front-line therapy, extensive
published evidence has accumulated that IV iron is superior, in both efficacy
and safety, to oral iron in many clinical situations and should be introduced
much sooner in the treatment paradigm of iron-deficient patients. In this
chapter, we will r...
Myelodysplastic Syndromes
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 297-317 - 2004
AbstractThe development of new therapeutic strategies for myelodysplastic
syndromes (MDS) has gained new momentum fueled by improved characterization of
the disease’s natural history and biology and by the recent US Food and Drug
Administration (FDA) approval of the first agent with an indication for MDS. By
integrating morphologic and cytogenetic features with greater discriminatory
power, the Wo...
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Hematology. American Society of Hematology. Education Program - Tập 2003 Số 1 - Trang 497-519 - 2003
AbstractAcquired abnormalities in platelets, endothelium, and their interaction
occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the
antiphospholipid syndrome. Although of distinct pathogeneses, these three
disorders have several clinical features in common, including thrombocytopenia
and the potential for life- and limb-threatening thrombotic events, ranging from
microvascular ...
Long-lasting recombinant factor VIII proteins for hemophilia A
Hematology. American Society of Hematology. Education Program - Tập 2013 Số 1 - Trang 37-43 - 2013
Abstract In the past 50 years, the lifespan of an individual affected with
severe hemophilia A has increased from a mere 20 years to near that of the
general unaffected population. These advances are the result of and parallel
advances in the development and manufacture of replacement therapies. We are now
poised to witness further technologic leaps with the development of
longer-lasting replaceme...
Sickle Cell and the Brain
Hematology. American Society of Hematology. Education Program - Tập 2001 Số 1 - Trang 31-46 - 2001
AbstractSickle cell disease affects many organ systems, but one of the major
morbidities is brain disease, especially stroke. In this paper, the etiology,
diagnosis, treatment, and prevention of clinical stroke, as well as so-called
“silent stroke,” are examined. Risk factors, diagnostic tools, and data from
prevention and treatment studies as well as issues pertaining to
neuropsychological functi...
Impact of bone disease and pain in thalassemia
Hematology. American Society of Hematology. Education Program - Tập 2017 Số 1 - Trang 272-277 - 2017
AbstractConventional treatment of thalassemia, namely regular blood transfusion
and iron chelation, improves perspectives and quality of life; however,
successful treatment leads to more time in which long-term complications such as
bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects,
from bone anatomy and bone quality to mineral density, may be affected, with
important...
Acute Myeloid Leukemia
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 98-117 - 2004
AbstractAdvances in our understanding of the pathophysiology of acute myeloid
leukemia (AML) have not yet led to major improvements in disease-free and
overall survival of adults with this disease. Only about one-third of those
between ages 18–60 who are diagnosed with AML can be cured; disease-free
survival is rare and current therapy devastating in older adults. In this
chapter, challenges in th...
Thrombotic Complications of Myeloma Therapy
Hematology. American Society of Hematology. Education Program - Tập 2006 Số 1 - Trang 348-355 - 2006
AbstractPatients with multiple myeloma are at relatively high baseline risk of
developing thromboembolic events (TEE), usually deep vein thromboses. There are
numerous contributing factors, among them certain treatment regimens that
include thalidomide or related compounds such as lenalidomide combined with
glucocorticoids and/or cytotoxic chemotherapy. The risk of developing TEE
appears to be par...
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