Hematology. American Society of Hematology. Education Program

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The 2008 WHO classification of lymphomas: implications for clinical practice and translational research
Hematology. American Society of Hematology. Education Program - Tập 2009 Số 1 - Trang 523-531 - 2009
Elaine S. Jaffe
AbstractThe 4th edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues published in 2008 builds upon the success of the 2001 3rd edition; new entities are defined, and solutions for problematic categories are sought. Recent studies have drawn attention to the biological overlap between classical Hodgkin lymphoma (CHL) and diffuse large ...... hiện toàn bộ
Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma
Hematology. American Society of Hematology. Education Program - Tập 2009 Số 1 - Trang 507-519 - 2009
Anas Younes
AbstractAlthough classical Hodgkin lymphoma (HL) is considered one of the most curable human cancers, the treatment of patients with relapsed and refractory disease, especially those who relapse after autologous stem cell transplantation, remains challenging. Furthermore, because the median age of the patients is in the mid-30s, the impact of early mortality on the...... hiện toàn bộ
Neurobiological Mechanisms of Pain in Sickle Cell Disease
Hematology. American Society of Hematology. Education Program - Tập 2010 Số 1 - Trang 403-408 - 2010
Zaijie J. Wang, Diana J. Wilkie, Robert E. Molokie
AbstractPain is a frequent complaint of people living with sickle cell disease (SCD); however, the neurobiology of pain in SCD remains poorly understood. Whereas this pain has been thought to be primarily related to visceral and somatic tissue injury subsequent to vaso-occlusion events, emerging evidence from human and animal studies has suggested that a component ...... hiện toàn bộ
TTP and ADAMTS13: When Is Testing Appropriate?
Hematology. American Society of Hematology. Education Program - Tập 2007 Số 1 - Trang 121-126 - 2007
Pier Mannuccio Mannucci, Flora Peyvandi
Abstract The last 10 years witnessed the publication of many studies on the pathophysiology of thrombotic thrombocytopenic purpura (TTP), a life-threatening disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and multiorgan failure. The most important finding was the identification of a novel metalloprotease, named ADAMTS13 (...... hiện toàn bộ
Recent Advances in Thrombotic Thrombocytopenic Purpura
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 407-423 - 2004
J. Evan Sadler, Joel L. Moake, Toshiyuki Miyata, James N. George
Abstract Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, accompanied by microvascular thrombosis that causes variable degrees of tissue ischemia and infarction. Intravascular coagulation is not a prominent feature of the disorder. Plasma exchange can induce remissions in approximat...... hiện toàn bộ
Antiphospholipid syndrome
Hematology. American Society of Hematology. Education Program - Tập 2013 Số 1 - Trang 675-680 - 2013
Wendy Lim
Abstract The antiphospholipid syndrome (APS) is defined by venous or arterial thrombosis and/or pregnancy morbidity in patients with persistent presence of antiphospholipid antibodies (aPLs). Catastrophic APS is the most severe form of APS, which is associated with rapid development of microvascular thrombosis resulting in multiorgan failure in patie...... hiện toàn bộ
Deep Venous Thrombosis
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 439-456 - 2004
José A. López, Clive Kearon, Agnes Y.Y. Lee
Abstract Venous thromboembolism (VTE), manifested as either deep venous thrombosis (DVT) or pulmonary embolism (PE), is an extremely common medical problem, occurring either in isolation or as a complication of other diseases or procedures. Yet, despite its frequency, much remains to be learned regarding the pathogenic mechanisms that initiate VTE, a...... hiện toàn bộ
Treatment of Pediatric Chronic Myeloid Leukemia in the Year 2010: Use of Tyrosine Kinase Inhibitors and Stem-Cell Transplantation
Hematology. American Society of Hematology. Education Program - Tập 2010 Số 1 - Trang 368-376 - 2010
Meinolf Suttorp, Frédéric Millot
AbstractAllogeneic hematopoietic stem cell transplantation (allo-SCT) remains the only proven cure for chronic myeloid leukemia (CML), a rare malignancy in childhood. With the excellent results induced by the tyrosine kinase inhibitor (TKI) imatinib in adults in the last decade, the appropriate management of children with CML has also changed radically, and only a ...... hiện toàn bộ
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Hematology. American Society of Hematology. Education Program - Tập 2003 Số 1 - Trang 497-519 - 2003
Theodore E. Warkentin, William C. Aird, Jacob H. Rand
AbstractAcquired abnormalities in platelets, endothelium, and their interaction occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome. Although of distinct pathogeneses, these three disorders have several clinical features in common, including thrombocytopenia and the potential for life- and limb-threatening thrombotic ev...... hiện toàn bộ
Prognosis of Myelodysplastic Syndromes
Hematology. American Society of Hematology. Education Program - Tập 2010 Số 1 - Trang 330-337 - 2010
Guillermo Garcia‐Manero
AbstractThe myelodysplastic syndromes (MDS) are a very complex group of hematopoietic disorders. The degree of complexity relates not only to the intrinsic pathobiological characteristics of the disease, but also to the group of patients whom it affects most frequently: older individuals or those who have been exposed to prior forms of chemotherapy. It is therefore...... hiện toàn bộ
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