Hematology. American Society of Hematology. Education Program
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Prognosis of Myelodysplastic SyndromesAbstract The myelodysplastic syndromes (MDS) are a very complex group of hematopoietic disorders. The degree of complexity relates not only to the intrinsic pathobiological characteristics of the disease, but also to the group of patients whom it affects most frequently: older individuals or those who have been exposed to prior forms of chemotherapy. It is therefore... ...
Hematology. American Society of Hematology. Education Program - Tập 2010 Số 1 - Trang 330-337 - 2010
Hypercoagulability in Sickle Cell Disease: New Approaches to an Old ProblemAbstract Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic system, and increased tissue factor expression, even in the non-crisis steady state. In addition, platelets and other cellular elements are chronically activated in the non... ...
Hematology. American Society of Hematology. Education Program - Tập 2007 Số 1 - Trang 91-96 - 2007
Antithrombotic therapy: triple therapy or triple threat?Abstract
Antithrombotic therapy plays an essential role in the management of some of the most common and morbid medical conditions. Triple oral antithrombotic therapy (TOAT) is defined as the administration of both therapeutic oral anticoagulation (OAC) and dual antiplatelet therapy (DAPT) to patients with indications for both treatments. The current... ...
Hematology. American Society of Hematology. Education Program - Tập 2012 Số 1 - Trang 547-552 - 2012
Single-dose intravenous iron for iron deficiency: a new paradigmAbstract Iron-deficiency anemia is the most common hematologic problem in the world. Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient pat... ...
Hematology. American Society of Hematology. Education Program - Tập 2016 Số 1 - Trang 57-66 - 2016
Myelodysplastic SyndromesAbstract The development of new therapeutic strategies for myelodysplastic syndromes (MDS) has gained new momentum fueled by improved characterization of the disease’s natural history and biology and by the recent US Food and Drug Administration (FDA) approval of the first agent with an indication for MDS. By integrating morphologic and cytogenetic features with gre... ...
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 297-317 - 2004
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid SyndromeAbstract Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome. Although of distinct pathogeneses, these three disorders have several clinical features in common, including thrombocytopenia and the potential for life- and limb-threatening thrombotic ev... ...
Hematology. American Society of Hematology. Education Program - Tập 2003 Số 1 - Trang 497-519 - 2003
Long-lasting recombinant factor VIII proteins for hemophilia AAbstract
In the past 50 years, the lifespan of an individual affected with severe hemophilia A has increased from a mere 20 years to near that of the general unaffected population. These advances are the result of and parallel advances in the development and manufacture of replacement therapies. We are now poised to witness further technologic leaps ... ...
Hematology. American Society of Hematology. Education Program - Tập 2013 Số 1 - Trang 37-43 - 2013
Sickle Cell and the BrainAbstract Sickle cell disease affects many organ systems, but one of the major morbidities is brain disease, especially stroke. In this paper, the etiology, diagnosis, treatment, and prevention of clinical stroke, as well as so-called “silent stroke,” are examined. Risk factors, diagnostic tools, and data from prevention and treatment studies as well as issues pertai... ...
Hematology. American Society of Hematology. Education Program - Tập 2001 Số 1 - Trang 31-46 - 2001
Impact of bone disease and pain in thalassemiaAbstract Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density... ...
Hematology. American Society of Hematology. Education Program - Tập 2017 Số 1 - Trang 272-277 - 2017
Acute Myeloid LeukemiaAbstract Advances in our understanding of the pathophysiology of acute myeloid leukemia (AML) have not yet led to major improvements in disease-free and overall survival of adults with this disease. Only about one-third of those between ages 18–60 who are diagnosed with AML can be cured; disease-free survival is rare and current therapy devastating in older adults. ... ...
Hematology. American Society of Hematology. Education Program - Tập 2004 Số 1 - Trang 98-117 - 2004
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