Heart Failure Reviews
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Magnetic resonance imaging in the evaluation of non-ischemic cardiomyopathies: Current applications and future perspectives
Heart Failure Reviews - - 2006
Patients with non-ischemic cardiomyopathy often represent a diagnostic challenge, and correct etiologic diagnosis may influence outcomes. Lately, delayed myocardial enhancement MR imaging has been developed and is currently being used for a growing number of clinical applications. On delayed enhancement MR images, scarring or fibrosis appears as an area of high signal intensity, and the pattern by......
Direct effects of adipokines on the heart: focus on adiponectin
Heart Failure Reviews - Tập 18 Số 5 - Trang 631-644 - 2013
Role of Angiotensin II in Hypertension-Induced Cardiac Hypertrophy and Failure
Heart Failure Reviews - Tập 3 - Trang 159-168 - 1999
Besides playing a role in blood-pressure regulation and salt and fluid homeostasis, the octapeptide angiotensin II mediates cell growth and differentiation. Its effects are dependent on angiotensin receptors, of which both AT1 and AT2 receptors are extensively described. In cardiac hypertrophy and heart failure, angiotensin receptors are differentially regulated. It is established that AT1 recepto......
Role of various proteases in cardiac remodeling and progression of heart failure
Heart Failure Reviews - Tập 17 - Trang 395-409 - 2011
It is believed that cardiac remodeling due to geometric and structural changes is a major mechanism for the progression of heart failure in different pathologies including hypertension, hypertrophic cardiomyopathy, dilated cardiomyopathy, diabetic cardiomyopathy, and myocardial infarction. Increases in the activities of proteolytic enzymes such as matrix metalloproteinases, calpains, cathepsins, a......
A reappraisal of the pharmacologic management of gastrointestinal bleeding in patients with continuous flow left ventricular assist devices
Heart Failure Reviews - Tập 26 - Trang 277-288 - 2020
Advancements in the design and functionality of continuous flow left ventricular assist devices (CF-LVADs), as well as a limited number of donor hearts, have resulted in an increased utilization of this therapy among advanced heart failure (HF) patients. Despite these advancements, gastrointestinal bleeding (GIB) remains a common complication after CF-LVAD implantation. The mechanism of GIB in the......
Levels of angiotensin peptides in healthy and cardiovascular/renal-diseased paediatric population—an investigative review
Heart Failure Reviews - Tập 24 - Trang 709-723 - 2019
The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure and homeostasis. Therefore, it is a commonly used target for pharmacotherapy of cardiovascular diseases in adults. However, the efficacy of this pharmacotherapy can only be limitedly derived into children. Comprehensive knowledge of the humoral parameters acting in the paediatric RAAS (e.g. angio......
Arrhythmias and vagus nerve stimulation
Heart Failure Reviews - Tập 16 - Trang 147-161 - 2010
Enhancing vagal tone by delivering electrical stimulation to the vagal nerves (VNS) is emerging as a promising novel therapy in heart failure. In addition, VNS is already an FDA-approved therapy for refractory epilepsy and depression. Besides its well-known negative chronotropic, inotropic, and dromotropic effects, VNS has profound effects on cardiac electrophysiology and arrhythmogenesis. This re......
Autophagy protects mitochondrial health in heart failure
Heart Failure Reviews - - 2023
The progression of heart failure is reported to be strongly associated with homeostatic imbalance, such as mitochondrial dysfunction and abnormal autophagy, in the cardiomyocytes. Mitochondrial dysfunction triggers autophagic and cardiac dysfunction. In turn, abnormal autophagy impairs mitochondrial function and leads to apoptosis or autophagic cell death under certain circumstances. These events ......
Granulocyte colony-stimulating factor for ischemic heart failure: should we use it?
Heart Failure Reviews - Tập 15 - Trang 613-623 - 2010
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine usually used in the treatment of patients with cancer. Studies have shown regenerative properties of bone marrow stem cell mobilization due to G-CSF in animals. Moreover, others effects related to G-CSF and independent of tissue regeneration were shown to be protective. As a result, this cytokine has been tested as a therapy......
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