Glycoconjugate Journal
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S5.9 Heparin-like compounds prepared by chemical modification of capsular polysaccharide from E. coli K5
Glycoconjugate Journal - Tập 10 - Trang 252-253 - 1993
Conformational equilibrium of unsulphated iduronate in heparan sulphate tetrasaccharides
Glycoconjugate Journal - Tập 2 - Trang 109-120 - 1985
Proton-proton coupling constants for terminal α-l-iduronate residues in tetrasaccharides obtained from heparan sulphates by complete nitrous acid deaminative cleavage were shown to vary with experimental conditions. It is proposed that the iduronate residue is in a conformational equilibrium between the1C4 chair and either the2So skewboat or possibly the2H3 half-chair conformers. It was not possib...... hiện toàn bộ
Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity
Glycoconjugate Journal - Tập 26 Số 1 - Trang 75-81 - 2009
Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates
Glycoconjugate Journal - Tập 27 - Trang 479-489 - 2010
Chondroitin sulfate (CS) containing GlcA-GalNAc(4,6-SO4) (E unit) and CS containing GlcA(2SO4)-GalNAc(6SO4) (D unit) have been implicated in various physiological functions. However, it has been poorly understood how the structure and contents of disulfated disaccharide units in CS contribute to these functions. We prepared CS libraries containing E unit or D unit in various proportions by in vitr...... hiện toàn bộ
Carbohydrate-binding activities of coagulation factors fibrinogen and fibrin
Glycoconjugate Journal - Tập 32 - Trang 385-392 - 2015
The coagulation factors fibrinogen and fibrin play important roles in the final stage of the blood coagulation cascade. It has not been revealed whether fibrinogen has lectin activity or not. Here we demonstrate that fibrinogen and fibrin have carbohydrate-specific binding activities that inhibit fibrin clot formation. A solid-phase binding study using sugar-biotinyl polymer probes revealed that f...... hiện toàn bộ
Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages
Glycoconjugate Journal - Tập 26 - Trang 1259-1274 - 2009
Using a focused glycan-gene microarray, we compared the glycosyltransferase (GT) and sulfotransferase gene expression profiles of human monocytes, dendritic cells (DCs) and macrophages (Mϕs), isolated or differentiated from the same donors. Microarray analysis indicated that monocytes express transcripts for a full set of enzymes involved in the biosynthesis of multi-multiantennary branched N-glyc...... hiện toàn bộ
Chemical validation of molecular mimicry: interaction of cholera toxin with Campylobacter lipooligosaccharides
Glycoconjugate Journal - Tập 24 - Trang 167-180 - 2007
It is generally believed that molecular mimicry between bacterial lipooligosaccharide (LOS) and nerve glycolipids may play an important pathogenic role in immune-mediated peripheral neuropathy. One of the putative infectious agents is Campylobacter jejuni (C. jejuni). To elucidate the structural basis for the molecular mimicry, we investigated the structure of the lipooligosaccharide (LOS) fractio...... hiện toàn bộ
A method for glycoconjugate synthesis
Glycoconjugate Journal - Tập 10 - Trang 133-141 - 1993
7-Formylheptyl glycosides of 2-acetamido-2-deoxy-β-d-glucopyranose andO-α-l-rhamnopyranosyl-(1 → 3)-O-α-l-rhamnopyranose were synthesized and were coupled by reductive amination to bovine serum albumin and aminopropyl glass, respectively.
Implication of N-glycolylneuraminic acid in regulation of cell adhesiveness of C2C12 myoblast cells during differentiation into myotube cells
Glycoconjugate Journal - Tập 39 - Trang 619-631 - 2022
A transition of sialic acid (Sia) species on GM3 ganglioside from N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc) takes place in mouse C2C12 myoblast cells during their differentiation into myotube cells. However, the meaning of this Sia transition remains unclear. This study thus aims to gain a functional insight into this phenomenon. The following lines of evidence show th...... hiện toàn bộ
Identification of a developmentally regulated sialidase inEimeria tenella that is immunologically related to theTrypanosoma cruzi enzyme
Glycoconjugate Journal - Tập 10 - Trang 57-63 - 1993
Sporozoites and merozoites of three species ofEimeria, E. tenella, E. maxima, andE. necatrix, that cause diarrhea in chickens worldwide, were examined for their expression of sialidase (SA) activity. The enzyme was found in three species, and the activity of merozoites was 10–20 times higher than that of sporozoites. The enzyme was resistant to degradation by proteases that are normally present in...... hiện toàn bộ
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