Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organizationGenome Biology - Tập 16 - Trang 1-14 - 2015
Benjamin L Moore, Stuart Aitken, Colin A Semple
Interphase chromosomes adopt a hierarchical structure, and recent data have characterized their chromatin organization at very different scales, from sub-genic regions associated with DNA-binding proteins at the order of tens or hundreds of bases, through larger regions with active or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear positioning, replication ti...... hiện toàn bộ
A whole-genome shotgun approach for assembling and anchoring the hexaploid bread wheat genomeGenome Biology - Tập 16 - Trang 1-17 - 2015
Jarrod A Chapman, Martin Mascher, Aydın Buluç, Kerrie Barry, Evangelos Georganas, Adam Session, Veronika Strnadova, Jerry Jenkins, Sunish Sehgal, Leonid Oliker, Jeremy Schmutz, Katherine A Yelick, Uwe Scholz, Robbie Waugh, Jesse A Poland, Gary J Muehlbauer, Nils Stein, Daniel S Rokhsar
Polyploid species have long been thought to be recalcitrant to whole-genome assembly. By combining high-throughput sequencing, recent developments in parallel computing, and genetic mapping, we derive, de novo, a sequence assembly representing 9.1 Gbp of the highly repetitive 16 Gbp genome of hexaploid wheat, Triticum aestivum, and assign 7.1 Gb of this assembly to chromosomal locations. The genom...... hiện toàn bộ
An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight lossGenome Biology - Tập 16 - Trang 1-21 - 2015
Miles C Benton, Alice Johnstone, David Eccles, Brennan Harmon, Mark T Hayes, Rod A Lea, Lyn Griffiths, Eric P Hoffman, Richard S Stubbs, Donia Macartney-Coxson
Environmental factors can influence obesity by epigenetic mechanisms. Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass provides a model to investigate obesity and weight loss in humans. Here, we investigate DNA methylation in adipose tissue from obese women before and after gastric bypass and significant weight loss. In total, 485,577 CpG sites were prof...... hiện toàn bộ