Genetical Research

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Polymorphism from environmental heterogeneity: models are only robust if the heterozygote is close in fitness to the favoured homozygote in each environment
Genetical Research - Tập 45 Số 3 - Trang 299-314 - 1985
Rolf F. Hoekstra, R. Bijlsma, A. J. Dolman
SummaryThe lack of robustness of models of the maintenance of polymorphism in a heterogeneous environment which has been pointed out by Maynard Smith & Hoekstra (1980), applies also to models based on habitat selection, on temporal variation and on density-regulated selection. Only if (partial) dominance ‘switches’ between environments such that the fitness of ...... hiện toàn bộ
Estimators for pairwise relatedness and individual inbreeding coefficients
Genetical Research - Tập 67 Số 2 - Trang 175-185 - 1996
Kermit Ritland
SummaryMethod-of-moments estimators (MMEs) for the two-gene coefficients of relationship and inbreeding, and for thxe four-gene Cotterman coefficients, are described. These estimators, which use co-dominant genetic markers, are most appropriate for estimating pairwise relatedness or individual inbreeding coefficients, as opposed to their mean values in a group. Thi...... hiện toàn bộ
The detection of a recessive visible gene in finite populations
Genetical Research - Tập 37 Số 1 - Trang 33-46 - 1981
Samuel Karlin, Simon Tavaré
Robertson, 1978, addressed the interesting problem of ascertaining the distribution of the time to detection of a recessive homozygote in a finite population. He was motivated in part by breeding and artificial selection practices. The same problem arises in the context of evolutionary processes and medical genetics since it refers to the time of first appearance as a homozygote of a new c...... hiện toàn bộ
A mechanism for gene conversion in fungi
Genetical Research - Tập 5 Số 2 - Trang 282-304 - 1964
Robin Holliday
A mechanism for gene conversion is proposed which overcomes many of the difficulties that any copy choice model encounters. It is suggested that along with general genetic pairing of homologous genomes at meiosis, effective pairing over short regions of the genetic material occurs at the molecular level by the separation of the strands of the DNA double helices, followed by the annealing o...... hiện toàn bộ
New evidence of unbalanced sex-chromosome constitutions in the mouse
Genetical Research - Tập 1 Số 2 - Trang 253-261 - 1960
Anne McLaren
Some anomalous results are described of genetical tests using the sex-linked markers Tabby and Bent-tail. The results are shown to be consistent with the demonstration by Welshons & Russell (1959) that the X/O chromosome constitution is female, and suggest that the condition can arise from non-disjunction in the female as well as fr...... hiện toàn bộ
Statistical design and the analysis of gene expression microarray data
Genetical Research - Tập 77 Số 2 - Trang 123-128 - 2001
Kathleen F. Kerr, Gary A. Churchill
Gene expression microarrays are an innovative technology with enormous promise to help geneticists explore and understand the genome. Although the potential of this technology has been clearly demonstrated, many important and interesting statistical questions persist. We relate certain features of microarrays to other kinds of experimental data and argue that classical statistical techniqu...... hiện toàn bộ
Linkage disequilibrium mapping of the bolting gene in sea beet using AFLP markers
Genetical Research - Tập 77 Số 1 - Trang 61-66 - 2001
Mats Hansen, Thomas Kraft, SARA GANESTAM, Torbjörn Säll, Nils‐Otto Nilsson
The possibility of using linkage disequilibrium mapping in natural plant populations was assessed. In studying linkage disequilibrium among 137 mapped AFLP markers in four populations of sea beet (Beta vulgaris ssp. maritima (L.) Arcang.) it was shown that tightly linked loci could be detected by screening for associations. It was hy...... hiện toàn bộ
A world-wide survey of genetic variation in the yellow fever mosquito,Aedes aegypti
Genetical Research - Tập 34 Số 3 - Trang 215-229 - 1979
Walter J. Tabachnick, Jeffrey R. Powell
SUMMARYThirty-four populations ofAedes aegyptirepresenting the world-wide distribution of the species, were analysed for genetic variation at 19–22 isozyme loci. The species has an average expected heterozygosity of 0·129±0·045 based on 19 loci analysed in every population. Based on this genetic information, two major groups can be define...... hiện toàn bộ
Mitotic non-conformity inAspergillus: successive and transposable genetic changes
Genetical Research - Tập 16 Số 1 - Trang 79-93 - 1970
João Lúcio de Azevedo, J. A. Roper
SUMMARYStrains ofAspergillus nidulanswith, a duplicate chromosome segment are mitotically unstable; in addition to phenotypically improved variants, arising following deletions in either duplicate segment, they give morphologically deteriorated types, some with, enhanced stability. In one isolate, deterioration and increased instability w...... hiện toàn bộ
The use ofp-fluorophenylalanine with ‘master strains’ ofAspergillus nidulansfor assigning genes to linkage groups
Genetical Research - Tập 6 Số 3 - Trang 352-359 - 1965
Kevin K. McCully, Emma Forbes
Four ‘master’ strains ofAspergillus nidulans, three of which are marked on each of the eight chromosomes, are used for assigning genes of unknown location to linkage groups. In this technique a heterozygous diploid is synthesized between one ‘master’ strain and a strain carrying an unlocated marker. This diploid is haploidized by growth onp... hiện toàn bộ
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