Mitotic non-conformity inAspergillus: successive and transposable genetic changes

Genetical Research - Tập 16 Số 1 - Trang 79-93 - 1970
João Lúcio de Azevedo1, J. A. Roper1
1Department of Genetics, The University, Sheffield S10 2TN

Tóm tắt

SUMMARYStrains ofAspergillus nidulanswith, a duplicate chromosome segment are mitotically unstable; in addition to phenotypically improved variants, arising following deletions in either duplicate segment, they give morphologically deteriorated types, some with, enhanced stability. In one isolate, deterioration and increased instability were determined by mutation in a duplicate segment; a more stable derivative no longer had this mutation but had one in another linkage group. Another variant, too unstable for analysis, gave derivatives whose single, new mutations were in different linkage groups. It is proposed that deterioration and increased instability result from tandem duplications on either duplicate segment; transposition of these to non-duplicated regions reduces instability. Another 17 variants had a single new mutation each; mutations, possibly clustered, occurred in all linkage groups. In these strains perhaps transposition preceded analysis. Deteriorated variants gave lineages of types with morphological changes caused by further, superimposed mutations. This continued instability is explained as interaction, in fidelity of replication, of non-homologous chromosome segments.Instability inA. nidulansstems from chromosome imbalance. As imbalance is known or suspected in other cases of instability it may be possible to show common mechanisms for apparently diverse phenomena.

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Tài liệu tham khảo

Rosenberger, 1968, Nonrandom sister chromatid segregation and nuclear migration in hyphae of Aspergillus nidulans, Journal of Bacteriology, 96, 1208, 10.1128/JB.96.4.1208-1213.1968

10.1017/S0016672300001968

10.1007/BF02168881

10.1017/S0016672300001853

Nga, 1968, Quantitative intrachromosomal changes arising at mitosis in Aspergillus nidulans, Genetics, 58, 193, 10.1093/genetics/58.2.193

10.1017/S0016672300004249

Green, 1969, Controlling element mediated transpositions of the white gene in Drosophila melanogaster, Genetics, 61, 429, 10.1093/genetics/61.2.429

10.1038/hdy.1963.1

Pollard, 1968, Influence of chromosomal aberrations on meiotic and mitcotic nondisjunction in Aspergillus nidulans, Genetics, 60, 743, 10.1093/genetics/60.4.743

Pontecorvo, 1953, The genetics of Aspergillus nidulans, Advances in Genetics, 5, 141, 10.1016/S0065-2660(08)60408-3

10.1038/hdy.1959.5

Callan, 1967, The organisation of genetic units in chromosomes, Journal of Cell Science, 2, 1, 10.1242/jcs.2.1.1

10.1016/S0007-1536(70)80128-0

10.1101/SQB.1951.016.01.004

McClintock, 1965, The control of gene action in maize, Brookhaven Symposia on Biology, 18, 162

Morpurgo, 1961, Somatic segregation induced by p-fluorophenylalanine, Aspergillus Newsletter, 2, 10

10.1016/0027-5107(70)90155-7

10.1099/00221287-49-1-149

10.1099/00221287-42-3-417

10.1017/S0016672300009629

Käfer, 1961, The processes of spontaneous recombination in vegetative nuclei of Aspergillus nidulans, Genetics, 46, 1581, 10.1093/genetics/46.12.1581

10.1038/215864a0

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Genetical Research

Tập 16 Số 1

79-93

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