Genes and Environment

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Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis
Genes and Environment - - 2016
Masaru Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi, Sakae Arimoto‐Kobayashi
Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association
Genes and Environment - Tập 43 - Trang 1-16 - 2021
Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato, Eiji Yamamura
Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico models for prediction remain to be improved. The Japan Pharmaceutical Manufacturers Association (JPMA) organized a task force in 2017 in which eight Japanese pharmaceutical companies had pa...... hiện toàn bộ
Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues
Genes and Environment - Tập 45 Số 1
Masayuki Mishima, Keiichi Sugiyama
Abstract Background Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs. Consideration ...... hiện toàn bộ
New indicator Escherichia coli strain for rapid and accurate detection of supF mutations
Genes and Environment - Tập 42 - Trang 1-9 - 2020
Ruriko Fukushima, Tetsuya Suzuki, Hiroyuki Kamiya
The supF gene of Escherichia coli is useful for forward mutation analysis in bacterial and mammalian cells used in mutagenesis and DNA repair studies. Indicator E. coli strains, such as KS40/pOF105, have been used to analyze supF mutations. However, KS40/pOF105 is not enough to select supF mutants on nutrient-rich agar plates. Therefore, in this study, a new indicator E. coli strain for rapid and ...... hiện toàn bộ
DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice
Genes and Environment - Tập 45 Số 1 - Trang 1-13 - 2023
Hakura, Atsushi, Sui, Hajime, Seki, Yuki, Sonoda, Jiro, Yoshida, Yusaku, Takagi, Hisayoshi, Yokose, Shigeo, Matsuda, Tomonari, Asakura, Shoji, Nohmi, Takehiko
Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced by inflammation in the colon of mice. In the present study, we examined whether Pol κ suppressed inflammation-induced colon tumorigenesis by treating inactivated Polk knock-in (Polk−/−) mice ...... hiện toàn bộ
Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique
Genes and Environment - Tập 40 - Trang 1-8 - 2018
Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Seiichiroh Ohsako
There is still considerable debate about the effects of exposure to bisphenol A (BPA) an endocrine disrupter at low doses. Recently, many studies using animal models have shown that prenatal BPA exposure induces behavioral and neuronal disorders due to epigenetic changes in the brain. However, striking evidence of epigenomic changes has to be shown. To investigate whether low-dose BPA exposure in ...... hiện toàn bộ
Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases
Genes and Environment - Tập 44 - Trang 1-8 - 2022
Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima, Hiroshi Miyazawa
Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua. We report here the following nucleotide incorporations opposite Ua by various DNA polymerases: DNA polymerase α, dATP and dGTP (dATP > dGTP); DNA polymerase δ, dATP; DNA polymeras...... hiện toàn bộ
Comprehensive analysis of differences of N6-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis
Genes and Environment - Tập 43 - Trang 1-10 - 2021
Xuejie Qi, Xiao Geng, Juan Zhang, Binpeng Qu, Xin Zhang, Qiang Jia, Wenhui Yin, Cunxiang Bo, Yan Liu, Hao Li, Linlin Sai, Mingming Han, Cheng Peng
Increasing evidence suggested N6-methyladenosine (m6A) modification is crucial for male germline development. However, m6A modification of lncRNAs gains a little attention in amphibians in recent years. Xenopus laevis (X. laevis) was chosen to be an ideal model organism for testing environmental endocrine disrupting chemicals (EDCs) exposure and resultant effects. Atrazine (AZ) as an endocrine dis...... hiện toàn bộ
The 30th summer school of the Research Community for Mechanisms of Mutations
Genes and Environment - Tập 40 - Trang 1-3 - 2018
Takashi Yagi, Masanobu Kawanishi, Kazuhiko Takahashi
The 30th summer school of the Research Community for Mechanisms of Mutations was held on September 2nd-3rd, 2017 at the Kyoto Prefecture Seminar House. The Community celebrated the 30th anniversary of the school this year. The Community has been organizing a meeting once a year since it was founded as the Society for Mechanisms of Anti-mutagenesis and Anti-carcinogenesis Studies in 1987. The Socie...... hiện toàn bộ
Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli
Genes and Environment - Tập 41 - Trang 1-10 - 2019
Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi, Tomoe Negishi
Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to suppress tumor development through DNA chloroethylation, followed by the formation of interstrand cross-links (ICLs) that efficiently block replication and transcription. However, the alkylatio...... hiện toàn bộ
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