Genes and Environment
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Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis
Genes and Environment - - 2016
Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association
Genes and Environment - Tập 43 - Trang 1-16 - 2021
Ames test is used worldwide for detecting the bacterial mutagenicity of
chemicals. In silico analyses of bacterial mutagenicity have recently gained
acceptance by regulatory agencies; however, current in silico models for
prediction remain to be improved. The Japan Pharmaceutical Manufacturers
Association (JPMA) organized a task force in 2017 in which eight Japanese
pharmaceutical companies had pa...
Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues
Genes and Environment - Tập 45 Số 1
Abstract Background Middle size peptides (MSPs) have emerged as a promising new
pharmaceutical modality. We are seeking the best way to assess the non-clinical
safety of MSPs. Consideration The requirements for assessing the genotoxicity of
pharmaceuticals differ between small molecule drugs and biotherapeutics.
Genotoxicity tests are necessary for small molecule drugs but not for
biotherapeutics....
New indicator Escherichia coli strain for rapid and accurate detection of supF mutations
Genes and Environment - Tập 42 - Trang 1-9 - 2020
The supF gene of Escherichia coli is useful for forward mutation analysis in
bacterial and mammalian cells used in mutagenesis and DNA repair studies.
Indicator E. coli strains, such as KS40/pOF105, have been used to analyze supF
mutations. However, KS40/pOF105 is not enough to select supF mutants on
nutrient-rich agar plates. Therefore, in this study, a new indicator E. coli
strain for rapid and ...
DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice
Genes and Environment - Tập 45 Số 1 - Trang 1-13 - 2023
Chronic inflammation induces DNA damage and promotes cell proliferation, thereby
increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion
DNA synthesis, counteracts mutagenesis induced by inflammation in the colon of
mice. In the present study, we examined whether Pol κ suppressed
inflammation-induced colon tumorigenesis by treating inactivated Polk knock-in
(Polk−/−) mice ...
Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique
Genes and Environment - Tập 40 - Trang 1-8 - 2018
There is still considerable debate about the effects of exposure to bisphenol A
(BPA) an endocrine disrupter at low doses. Recently, many studies using animal
models have shown that prenatal BPA exposure induces behavioral and neuronal
disorders due to epigenetic changes in the brain. However, striking evidence of
epigenomic changes has to be shown. To investigate whether low-dose BPA exposure
in ...
Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases
Genes and Environment - Tập 44 - Trang 1-8 - 2022
Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and
guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated
dATP opposite Ua, and that DNA polymerase β was blocked by Ua. We report here
the following nucleotide incorporations opposite Ua by various DNA polymerases:
DNA polymerase α, dATP and dGTP (dATP > dGTP); DNA polymerase δ, dATP; DNA
polymeras...
Comprehensive analysis of differences of N6-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis
Genes and Environment - Tập 43 - Trang 1-10 - 2021
Increasing evidence suggested N6-methyladenosine (m6A) modification is crucial
for male germline development. However, m6A modification of lncRNAs gains a
little attention in amphibians in recent years. Xenopus laevis (X. laevis) was
chosen to be an ideal model organism for testing environmental endocrine
disrupting chemicals (EDCs) exposure and resultant effects. Atrazine (AZ) as an
endocrine dis...
The 30th summer school of the Research Community for Mechanisms of Mutations
Genes and Environment - Tập 40 - Trang 1-3 - 2018
The 30th summer school of the Research Community for Mechanisms of Mutations was
held on September 2nd-3rd, 2017 at the Kyoto Prefecture Seminar House. The
Community celebrated the 30th anniversary of the school this year. The Community
has been organizing a meeting once a year since it was founded as the Society
for Mechanisms of Anti-mutagenesis and Anti-carcinogenesis Studies in 1987. The
Socie...
Absolute quantification of DNA damage response proteins
Genes and Environment - Tập 45 - Trang 1-7 - 2023
DNA damage response (DDR) and repair are vital for safeguarding genetic
information and ensuring the survival and accurate transmission of genetic
material. DNA damage, such as DNA double-strand breaks (DSBs), triggers a
response where sensor proteins recognize DSBs. Information is transmitted to
kinases, initiating a sequence resulting in the activation of the DNA damage
response and recruitment ...
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