Genes and Environment
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Gut microbiota and colorectal cancer
Genes and Environment - Tập 38 - Trang 1-7 - 2016
The mucosal immune system is unique to the gastrointestinal mucosa, in which a large number of immune cells are located and exert multiple functions. Meanwhile, ~100 trillion microorganisms are thought to co-inhabit in the gastrointestinal tract. Furthermore, immune cells and gut microbiota have a mutual influence and the maintenance of this symbiotic relationship results in gut homeostasis. A rec...... hiện toàn bộ
Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats
Genes and Environment - Tập 43 - Trang 1-12 - 2021
Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of silicosis in rats exposed to RCS with focus on the regulation of long noncoding RNAs (lncRNAs). The results showed that RCS induced acute inflammatory response as indicated by the appearance...... hiện toàn bộ
Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids
Genes and Environment - Tập 42 - Trang 1-19 - 2020
Sex steroid hormone receptors are classified into three classes of receptors: estrogen receptors (ER) α and β, androgen receptor (AR), and progesterone receptor (PR). They belong to the nuclear receptor superfamily and activate their downstream genes in a ligand-dependent manner. Since sex steroid hormones are involved in a wide variety of physiological processes and cancer development, synthetic ...... hiện toàn bộ
Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19
Genes and Environment - Tập 42 - Trang 1-14 - 2020
Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by front-line healthcare workers and other common people as a prophylactic drug against the Corona Virus Disease − 19 (COVID-19) in India and as well as in many parts of the world. While only a few in vitro studies have pointed to some efficacy of these drugs as a prophylactic against COVI...... hiện toàn bộ
Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han populationAbstract
Objectives
To evaluate the relationship between transcription factor 7-like 2 (TCF7L2 ) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population.
... hiện toàn bộ
Genes and Environment - Tập 43 Số 1 - 2021
LncRNA PVT1 induces apoptosis and inflammatory response of bronchial epithelial cells by regulating miR-30b-5p/BCL2L11 axis in COPD
Genes and Environment - Tập 45 - Trang 1-10 - 2023
Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as a biomarker for COPD progression. Nonetheless, its specific functions and mechanisms in COPD are unclarified. Cigarette smoke extract (CSE) was utilized to stimulate 16HBE cells, and cigarette smoke combining with...... hiện toàn bộ
Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages
Genes and Environment - - 2015
Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy
Genes and Environment - Tập 45 - Trang 1-12 - 2023
Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, the association between polymorphisms in autophagy-related genes and GMA must be fully elucidated. We evaluated the association between single nucleotide polymorphisms (SNPs) in autophagy-...... hiện toàn bộ
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