Genes and Environment

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Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls
Genes and Environment -
Roderick H. Dashwood
AbstractBefore ‘cancer interception’ was first advocated, ‘interceptor molecules’ had been conceived as a sub-category of preventive agents that interfered with the earliest initiation steps in carcinogenesis. Three decades ago, a seminal review cataloged over fifty synthetic agents and natural products that were known or putative interceptor molecules. Chlorophyll...... hiện toàn bộ
Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays
Genes and Environment - Tập 40 - Trang 1-10 - 2018
Arihiro Kohara, Mariko Matsumoto, Akihiko Hirose, Makoto Hayashi, Masamitsu Honma, Takayoshi Suzuki
The carcinogenic potential of dimethylaniline (DMA) isomers in rodents and humans has been previously reported, and there is sufficient evidence for the carcinogenicity of 2,6-DMA in experimental animals. The target organ of carcinogenesis of 2,6-DMA is the nasal cavity. In the current study, six DMA isomers, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-DMA, were evaluated for mutagenic properties. Male d...... hiện toàn bộ
Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell
Genes and Environment - Tập 45 - Trang 1-10 - 2023
Takahiro Matsumoto, Erika Ohnishi, Takahiro Kitagawa, Masaya Okayama, Youhei Saito, Hayato Yoshikawa, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama, Tetsushi Watanabe
Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemotherapeutic agents and may be effective with a reduced dosage for tumor therapy to avoid side effects. Four new azaphilones, maximazaphilones I–IV (1–4), and three known compounds (5–7) have bee...... hiện toàn bộ
Reactions of 3′,5′-di-O-acetyl-2′-deoxyguansoine and 3′,5′-di-O-acetyl-2′-deoxyadenosine to UV light in the presence of uric acid
Genes and Environment - Tập 44 - Trang 1-9 - 2022
Toshinori Suzuki, Miyu Takeuchi, Atsuko Ozawa-Tamura
Recently, it was revealed that uric acid is a photosensitizer of reactions of nucleosides on irradiation with UV light at wavelengths longer than 300 nm, and two products generated from 2′-deoxycytidine were identified. In the present study, UV reactions of acetylated derivatives of 2′-deoxyguansoine and 2′-deoxyadenosine were conducted and their products were identified. Each reaction of 3′,5′-di...... hiện toàn bộ
Selective enhancing effect of metal ions on mutagenicity
Genes and Environment - Tập 38 - Trang 1-8 - 2016
Nobuyoshi Fujii, Shigemitsu Yano, Kenji Takeshita
We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-nitroquinoline 1-oxide (4NQO), quercetin, 2-aminoanthracene (2-AA), benzo[a]pyrene, and 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole, in the presence of five metal ions: Ca(II), Mg(II), Mn(II),...... hiện toàn bộ
Transgenic rat models for mutagenesis and carcinogenesis
Genes and Environment - Tập 39 - Trang 1-32 - 2017
Takehiko Nohmi, Kenichi Masumura, Naomi Toyoda-Hokaiwado
Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological research than mice. This is partly because they live longer than mice and induce a wider variety of tumors, which are morphologically similar to those in humans. The body mass is larger than mice,...... hiện toàn bộ
Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis
Genes and Environment - - 2016
Masaru Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi, Sakae Arimoto‐Kobayashi
Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association
Genes and Environment - Tập 43 - Trang 1-16 - 2021
Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato, Eiji Yamamura
Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico models for prediction remain to be improved. The Japan Pharmaceutical Manufacturers Association (JPMA) organized a task force in 2017 in which eight Japanese pharmaceutical companies had pa...... hiện toàn bộ
Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues
Genes and Environment - Tập 45 Số 1
Masayuki Mishima, Keiichi Sugiyama
Abstract Background Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs. Consideration ...... hiện toàn bộ
New indicator Escherichia coli strain for rapid and accurate detection of supF mutations
Genes and Environment - Tập 42 - Trang 1-9 - 2020
Ruriko Fukushima, Tetsuya Suzuki, Hiroyuki Kamiya
The supF gene of Escherichia coli is useful for forward mutation analysis in bacterial and mammalian cells used in mutagenesis and DNA repair studies. Indicator E. coli strains, such as KS40/pOF105, have been used to analyze supF mutations. However, KS40/pOF105 is not enough to select supF mutants on nutrient-rich agar plates. Therefore, in this study, a new indicator E. coli strain for rapid and ...... hiện toàn bộ
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