Genes and Development
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New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesisAcinetobacter baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections including pneumonia, meningitis, septicemia, and urinary tract infections. We explored the pathogenic content of this harmful pathogen using a combination of DNA sequencing and insertional mutagenesis. The genome of this o...
Genes and Development - Tập 21 Số 5 - Trang 601-614 - 2007
Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonucleaseThe RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA replication to restart forks that have paused due to DNA damage or topological stress. We have shown previously that yeast cells lackingSGS1 or TOP3 require MMS4 and MUS... ...
Genes and Development - Tập 15 Số 20 - Trang 2730-2740 - 2001
Chromosome integrity inSaccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and originsThe integrity of chromosomes during cell division is ensured by bothtrans -acting factors andcis -acting chromosomal sites. Failure of either these chromosome integrity determinants (CIDs) can cause chromosomes to be broken and subsequently misrepaired to form gross chromosomal rearrangements (GCRs). We developed a simple and rapid assay ... ...
Genes and Development - Tập 17 Số 14 - Trang 1741-1754 - 2003
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndromeRemoval of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 by activated protein kinase C. In contrast, genetic studies in yeast indicate a requirement for the ortholog of theSBDS...
Genes and Development - Tập 25 Số 9 - Trang 917-929 - 2011
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cTNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release. Surprisingly, the three-dimensional structure of this BH3 domain-only molecule revealed two hydrophobic α-helices suggesting tBID itself might be a pore-forming protein. Instead, we demons... ...
Genes and Development - Tập 14 Số 16 - Trang 2060-2071 - 2000
Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.A novel cellular protein, Abl-interactor-1 (Abi-1), which specifically interacts with the carboxy-terminal region of Abl oncoproteins, has been identified in a mouse leukemia cell line. The protein exhibits sequence similarity to homeotic genes, contains several polyproline stretches, and includes a src homology 3 (SH3) domain at its very carboxyl terminus that is required for binding to A... ...
Genes and Development - Tập 9 Số 21 - Trang 2583-2597 - 1995
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoActivated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. Research over the last two decades has revealed the particular importance of the Akt pathway, and its molecular antagonist PTEN (phosphatase and tensin homolog), in the process of gliomagenesis. Recent studies have also demonstrated that... ...
Genes and Development - Tập 23 Số 11 - Trang 1327-1337 - 2009
Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milkLactation is a highly demanding lipid synthesis and transport process that is crucial for the development of newborn mammals. While PPARγ is known to promote adipogenesis and lipogenesis in adipose tissue, its role in the lactating mammary gland is unexplored. Here, we report that a targeted deletion of PPARγ in mice results in the production of “toxic milk” containing elevated levels of i... ...
Genes and Development - Tập 21 Số 15 - Trang 1895-1908 - 2007
Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in DrosophilaThe conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA polymerase II in a splicing-dependent fashion; however, how TREX functions is poorly understood. Here we show that Thoc5 and other TREX components are essential for the biogenesis of piRNA, a distinct class of small ... ...
Genes and Development - Tập 30 Số 7 - Trang 840-855 - 2016
Encoding NF-κB temporal control in response to TNF: distinct roles for the negative regulators IκBα and A20TNF-induced NF-κB activity shows complex temporal regulation whose different phases lead to distinct gene expression programs. Combining experimental studies and mathematical modeling, we identify two temporal amplification steps—one determined by the obligate negative feedback regulator IκBα—that define the duration of the first phase of NF-κB activity. The second phase is defined by A20,... ...
Genes and Development - Tập 22 Số 15 - Trang 2093-2101 - 2008
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