Genes and Development

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Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione
Genes and Development - Tập 23 Số 12 - Trang 1387-1392 - 2009
Wenchi Zhang, Liang Wang, Yijin Liu, Ji-Wei Xu, Guangyu Zhu, Huaixing Cang, Xuemei Li, Mark Bartlam, Kenneth Hensley, Guangpu Li, Zihe Rao, Xuejun C. Zhang
Eukaryotic lanthionine synthetase C-like protein 1 (LanCL1) is homologous to prokaryotic lanthionine cyclases, yet its biochemical functions remain elusive. We report the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs. We also demonstrate by in vitro aff...... hiện toàn bộ
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
Genes and Development - Tập 13 Số 11 - Trang 1412-1421 - 1999
Jocelyn E. Krebs, Min‐Hao Kuo, C. David Allis, Craig L. Peterson
The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells
Genes and Development - Tập 33 Số 11-12 - Trang 669-683 - 2019
Charles Ng, Martin Aichinger, Tung Nguyen, Christy Au, Tariq Najar, Lin Wu, Kai R. Mesa, Will Liao, Jean-Pierre Quivy, Benjamin Hubert, Genevieve Almouzni, Johannes Zuber, Dan R. Littman
The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells
Genes and Development - Tập 33 Số 11-12 - Trang 669-683 - 2019
Charles Ng, Martin Aichinger, Tung Nguyen, Christy Au, Tariq Najar, Lin Wu, Kai R. Mesa, Will Liao, Jean-Pierre Quivy, Benjamin Hubert, Genevieve Almouzni, Johannes Zuber, Dan R. Littman
β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
Genes and Development - Tập 17 Số 19 - Trang 2465-2479 - 2003
Attila Aszódi, Ernst B. Hunziker, Cord Brakebusch, Reinhard Fässler
β1 integrins are highly expressed on chondrocytes, where they mediate adhesion to cartilage matrix proteins. To assess the functions of β1 integrin during skeletogenesis, we inactivated the β1 integrin gene in chondrocytes. We show here that these mutant mice develop a chondrodysplasia of various severity. β1-deficient chondrocytes had an abnormal shape and faile...... hiện toàn bộ
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
Genes and Development - Tập 25 Số 18 - Trang 1895-1908 - 2011
D. Grahame Hardie
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP. Although best known for its effects on metabolism, AMPK has many other f...... hiện toàn bộ
Meiotic chromosomes: it takes two to tango
Genes and Development - Tập 11 Số 20 - Trang 2600-2621 - 1997
G. Shirleen Roeder
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair
Genes and Development - Tập 31 Số 3 - Trang 260-274 - 2017
Justin Leung, Nodar Makharashvili, P. K. Agarwal, Li-Ya Chiu, Renaud Pourpre, Michael B. Cammarata, Joe R. Cannon, Alana Sherker, Daniel Durocher, Jennifer S. Brodbelt, Tanya T. Paull, Kyle M. Miller
Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ, and macroH2A represent key chromatin constituents that facilitate DNA repair. Through proteomic screening of these variants, we identified ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interac...... hiện toàn bộ
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells
Genes and Development - Tập 36 Số 11-12 - Trang 752-763 - 2022
Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S. Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M. Bernt, Marisa S. Bartolomei, Mengcheng Luo, P. Jeremy Wang
Self-renewal of spermatogonial stem cells is vital to lifelong production of male gametes and thus fertility. However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for spermatogonial stem cell self-renewal. Mice lacking DOT1L fail to maintain spermatogonial stem cells, characterized by a sequential loss of germ cells fr...... hiện toàn bộ
Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2
Genes and Development - Tập 33 Số 13-14 - Trang 799-813 - 2019
Aaron J. Plys, Christopher P. Davis, Jongmin Kim, Gizem Rizki, Madeline M. Keenen, Sharon K. Marr, Robert E. Kingston
Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include a set of canonical PRC1 complexes, each of which contains four core proteins, including one from the CBX family. These complexes have been sho...... hiện toàn bộ
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