Genes and Development

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Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
Genes and Development - Tập 22 Số 23 - Trang 3236-3241 - 2008
Ryan Doonan, Joshua McElwee, Filip Matthijssens, Glenda A Walker, Koen Houthoofd, Patricia Back, Andrea Matscheski, Jacques R. Vanfleteren, David Gems
The superoxide radical (O2−) has long been considered a major cause of aging. O2− in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating...... hiện toàn bộ
New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis
Genes and Development - Tập 21 Số 5 - Trang 601-614 - 2007
Michael G. Smith, Tara A. Gianoulis, Stefan Pukatzki, John J. Mekalanos, L. Nicholas Ornston, Mark Gerstein, M Snyder
Acinetobacter baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections including pneumonia, meningitis, septicemia, and urinary tract infections. We explored the pathogenic content of this harmful pathogen using a combination of DNA sequencing and insertional mutagenesis. The genome of this o...... hiện toàn bộ
Slx1—Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1—Top3
Genes and Development - Tập 17 Số 14 - Trang 1768-1778 - 2003
William M. Fricke, Steven J. Brill
The RecQ DNA helicases human BLM and yeast Sgs1 interact with DNA topoisomerase III and are thought to act on stalled replication forks to maintain genome stability. To gain insight into this mechanism, we previously identifiedSLX1andSLX4as genes that are required for viability and for completion of rDNA replication in the absence of... hiện toàn bộ
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase
Genes and Development - Tập 19 Số 3 - Trang 339-350 - 2005
Giordano Liberi, Giulio Maffioletti, Chiara Lucca, Irene Chiolo, Anastasia Baryshnikova, Cecilia Cotta‐Ramusino, Massimo Lopes, Achille Pellicioli, James E. Haber, Marco Foiani
S-phase cells overcome chromosome lesions through replication-coupled recombination processes that seem to be assisted by recombination-dependent DNA structures and/or replication-related sister chromatid junctions. RecQ helicases, including yeast Sgs1 and human BLM, have been implicated in both replication and recombination and protect genome integrity by preventing unscheduled mitotic re...... hiện toàn bộ
Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonuclease
Genes and Development - Tập 15 Số 20 - Trang 2730-2740 - 2001
Vivek Kaliraman, Janet R. Mullen, William M. Fricke, Suzanne A. Bastin-Shanower, Steven J. Brill
The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA replication to restart forks that have paused due to DNA damage or topological stress. We have shown previously that yeast cells lackingSGS1 or TOP3 require MMS4 and MUS...... hiện toàn bộ
Chromosome integrity inSaccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins
Genes and Development - Tập 17 Số 14 - Trang 1741-1754 - 2003
Dongli Huang, Douglas Koshland
The integrity of chromosomes during cell division is ensured by bothtrans-acting factors andcis-acting chromosomal sites. Failure of either these chromosome integrity determinants (CIDs) can cause chromosomes to be broken and subsequently misrepaired to form gross chromosomal rearrangements (GCRs). We developed a simple and rapid assay ...... hiện toàn bộ
Activation and repression of mammalian gene expression by the c-myc protein.
Genes and Development - Tập 1 Số 4 - Trang 347-357 - 1987
Rima Kaddurah‐Daouk, J. M. Greene, Albert S. Baldwin, Robert E. Kingston
One mechanism by which nuclear-localized oncogenes might transform cells is through an ability to regulate gene expression. We show that the c-myc protein stimulates the level of appropriately initiated expression from the human heat shock protein 70 (hsp70) promoter. Sequences required for full activation lie upstream of the transcription initiation site and are distinct from sequences ne...... hiện toàn bộ
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome
Genes and Development - Tập 25 Số 9 - Trang 917-929 - 2011
Andrew J. Finch, Christine Hilcenko, Nicolas Basse, Lesley Drynan, Beatriz Goyenechea, Tobias Menne, África González‐Fernández, Paul J. Simpson, Clive S. D’Santos, Mark J. Arends, Jean Donadieu, Christine Bellanné‐Chantelot, Michael Costanzo, Charles Boone, Andrew N. J. McKenzie, Stefan Freund, Alan J. Warren
Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 by activated protein kinase C. In contrast, genetic studies in yeast indicate a requirement for the ortholog of theSBDS... hiện toàn bộ
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
Genes and Development - Tập 14 Số 16 - Trang 2060-2071 - 2000
Michael C. Wei, Tullia Lindsten, Vamsi K. Mootha, Solly Weiler, Atan Gross, Mona Ashiya, Boris Turk, Stanley J. Korsmeyer
TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release. Surprisingly, the three-dimensional structure of this BH3 domain-only molecule revealed two hydrophobic α-helices suggesting tBID itself might be a pore-forming protein. Instead, we demons...... hiện toàn bộ
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
Genes and Development - Tập 13 Số 10 - Trang 1211-1233 - 1999
Randal J. Kaufman
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