Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma: Japanese subgroup analysis of the REACH trialGastroenterologia Japonica - Tập 52 - Trang 494-503 - 2016
Masatoshi Kudo, Etsuro Hatano, Shinichi Ohkawa, Hirofumi Fujii, Akihide Masumoto, Junji Furuse, Yoshiyuki Wada, Hiroshi Ishii, Shuntaro Obi, Shuichi Kaneko, Seiji Kawazoe, Osamu Yokosuka, Masafumi Ikeda, Katsuaki Ukai, Sojiro Morita, Akihito Tsuji, Toshihiro Kudo, Mitsuo Shimada, Yukio Osaki, Ryosuke Tateishi, Gen Sugiyama, Paolo Benjamin Abada, Ling Yang, Takuji Okusaka, Andrew Xiuxuan Zhu
REACH evaluated ramucirumab in the second-line treatment of patients with advanced hepatocellular carcinoma. In the intent-to-treat population (n = 565), a significant improvement in overall survival (OS) was not observed. In patients with an elevated baseline α-fetoprotein (AFP) level (400 ng/mL or greater), an improvement in OS was demonstrated. An analysis of the Japanese patients in REACH was ...... hiện toàn bộ
Significance of superoxide dismutase (SOD) in human colorectal cancer tissue: Correlation with malignant intensityGastroenterologia Japonica - Tập 30 - Trang 177-182 - 1995
Akira Satomi, Saburou Murakami, Taiju Hashimoto, Kiyoshi Ishida, Moriyuki Matsuki, Masaru Sonoda
The significance of superoxide dismutase (SOD) activity in colorectal cancer tissue was determined from the aspect of the antioxidant defense system. SOD activity and thiobarbituric acid reactive substance were measured in the tumor, in tissues adjacent to the tumor, and in regions that appeared normal, and the results were analyzed in terms of various histopathological factors (stage of disease, ...... hiện toàn bộ
Immunoreactivity of antimitochondrial autoantibodies in Japanese patients with primary biliary cirrhosisGastroenterologia Japonica - Tập 31 - Trang 61-68 - 1996
Katsuhisa Omagari, Merrill J. Rowley, Jennifer A. Jois, Sandra J. Feeney, Kohei Komatsu, Takashi Maeda, Saburo Onishi, Kiyoshi Yamazaki, Kazuyuki Suzuki, Claudio Galperin, Ian R. Mackay
The incidence and prevalence of primary biliary cirrhosis show wide geographic differences. The frequency of this disease in Japan is lower than in Northern Europe. To elucidate the immunoreactivity of serum with enzymes of the 2-oxo-acid dehydrogenase complex (2-OADC) and the M2 mitochondrial antigenic complex in Japanese patients, we examined sera from 107 patients with primary biliary cirrhosis...... hiện toàn bộ
Clinical and pathophysiological aspects of type 1 autoimmune pancreatitisGastroenterologia Japonica - Tập 53 - Trang 475-483 - 2018
Kazushige Uchida, Kazuichi Okazaki
In 1995, Yoshida and colleagues proposed the concept of “autoimmune pancreatitis” (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocy...... hiện toàn bộ
The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patientsGastroenterologia Japonica - Tập 52 - Trang 366-375 - 2016
Ayako Urabe, Michio Imamura, Masataka Tsuge, Hiromi Kan, Hatsue Fujino, Takayuki Fukuhara, Keiichi Masaki, Tomoki Kobayashi, Atsushi Ono, Takashi Nakahara, Tomokazu Kawaoka, Akira Hiramatsu, Yoshiiku Kawakami, Hiroshi Aikata, Clair Nelson Hayes, Noboru Maki, Hideaki Ohdan, Kazuaki Chayama
Post-transplant hepatitis B virus (HBV) reinfection is one of the major problems facing patients who undergo HBV-related liver transplantation (LT). We analyzed the clinical impact of serum hepatitis B core-related antigen (HBcrAg) on HBV reinfection in post-LT patients with HBV-related liver diseases. Serum hepatitis B surface antigen (HBsAg), HBV DNA, and HBcrAg were measured over time in 32 pos...... hiện toàn bộ
Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virusGastroenterologia Japonica - Tập 45 Số 1 - Trang 95-104 - 2010
Kohichiroh Yasui, Yuichi Harano, Hironori Mitsuyoshi, Kazuhiro Tsuji, Mio Endo, Tomoaki Nakajima, Masahito Minami, Yoshito Itoh, Yoh Zen, Yasuni Nakanuma, Toshikazu Yoshikawa, Takeshi Okanoue