Doxycycline attenuates l-DOPA-induced dyskinesia through an anti-inflammatory effect in a hemiparkinsonian mouse modelFrontiers in Pharmacology - Tập 13
Maurício dos Santos Pereira, Glauce Crivelaro Nascimento, Mariza Bortolanza, Patrick P. Michel, Rita Raisman‐Vozari, Elaine Del‐Bel
The pharmacological manipulation of neuroinflammation appears to be a promising
strategy to alleviate l-DOPA-induced dyskinesia (LID) in Parkinson’s disease
(PD). Doxycycline (Doxy), a semisynthetic brain-penetrant tetracycline
antibiotic having interesting anti-inflammatory properties, we addressed the
possibility that this compound could resolve LID in l-DOPA-treated C57BL/6 mice
presenting eith... hiện toàn bộ