Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors

Adams, 2015, Big opportunities for small molecules in immuno-oncology, Nat. Rev. Drug Discov., 14, 603, 10.1038/nrd4596

Bertolet, 1997, Myocardial infarction related atrial fibrillation: role of endogenous adenosine, Heart, 78, 88, 10.1136/hrt.78.1.88

Boknik, 1997, Characterization of biochemical effects of CGS 21680C, an A2-adenosine receptor agonist, in the mammalian ventricle, J. Cardiovasc. Pharmacol., 30, 750, 10.1097/00005344-199712000-00009

Boknik, 2018, Phenotyping of mice with heart specific overexpression of A2A-adenosine receptors: evidence for cardioprotective effects of A2A-adenosine receptors, Front. Pharmacol., 9, 13, 10.3389/fphar.2018.00013

Boldt, 2006, ACE-inhibitor treatment attenuates atrial structural remodeling in patients with lone chronic atrial fibrillation, Basic Res. Cardiol., 101, 261, 10.1007/s00395-005-0571-2

Burgueño, 2003, The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin, J. Biol. Chem., 278, 37545, 10.1074/jbc.M302809200

Cargnoni, 1999, Role of A2A receptor in the modulation of myocardial reperfusion damage, J. Cardiovasc. Pharmacol., 33, 883, 10.1097/00005344-199906000-00008

Cerqueira, 2008, Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results, JACC Cardiovasc. Imaging, 1, 307, 10.1016/j.jcmg.2008.02.003

Chan, 2008, Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor, Clin. Transl. Sci., 1, 126, 10.1111/j.1752-8062.2008.00027.x

Cheng, 2016, The MAPK pathway is involved in the regulation of rapid pacing-induced ionic channel remodeling in rat atrial myocytes, Mol. Med. Rep., 13, 2677, 10.3892/mmr.2016.4862

Drury, 1929, The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart, J. Physiol., 68, 213, 10.1113/jphysiol.1929.sp002608

Ezeani, 2017, Necessity to evaluate PI3K/Akt signalling pathway in proarrhythmia, Open Heart, 4, 10.1136/openhrt-2017-000596

Fabritz, 2004, Gene dose-dependent atrial arrhythmias, heart block and atrial brady-cardiomyopathy in mice overexpressing the A3-adenosine receptor, Cardiovasc. Res., 62, 500, 10.1016/j.cardiores.2004.02.004

Gassanov, 2006, Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: potential role for early remodeling in atrial fibrillation, Cell Calcium, 39, 175, 10.1016/j.ceca.2005.10.008

Gergs, 2004, Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function, J. Biol. Chem., 279, 40827, 10.1074/jbc.M405770200

Gergs, 2008, A positive inotropic effect of ATP in the human heart, Am. J. Physiol. Heart Circ. Physiol., 294, H1716, 10.1152/ajpheart.00945.2007

Gergs, 2010, Cardiac overexpression of the human 5-HT4 receptor in mice, Am. J. Physiol. Heart Circ. Physiol., 299, H788, 10.1152/ajpheart.00691.2009

Gergs, 2013, Human 5-HT₄-receptor stimulation in atria of transgenic mice, Naunyn Schmiedebergs Arch. Pharmacol., 386, 357, 10.1007/s00210-013-0831-x

Gergs, 2018, Mechanism underlying the contractile activity of UTP in the mammalian heart, Eur. J. Pharmacol., 830, 47, 10.1016/j.ejphar.2018.04.013

Goette, 2000, Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans, Circulation, 101, 2678, 10.1161/01.CIR.101.23.2678

Hamad, 2010, Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity, Am. J. Physiol. Heart Circ. Physiol., 298, H1738, 10.1152/ajpheart.00688.2009

Hamad, 2012, Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload, PLoS One, 7, 10.1371/journal.pone.0039919

Hauser, 2014, Tozadenant (SYN115) in patients with Parkinson’s disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial, Lancet Neurol., 13, 767, 10.1016/S1474-4422(14)70148-6

Hove-Madsen, 2004, Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes, Circulation, 110, 1358, 10.1161/01.CIR.0000141296.59876.87

Hove-Madsen, 2006, Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release, Cardiovasc. Res., 72, 292, 10.1016/j.cardiores.2006.07.020

Hu, 2019, AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death, Physiol. Rep., 7, 10.14814/phy2.13957

Isa-Param, 2006, Inducibility of atrial arrhythmias after adenosine and isoproterenol infusion in patients referred for atrial fibrillation ablation, Rev. Esp. Cardiol., 59, 559, 10.1157/13089743

Kilpatrick, 2002, Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization, Am. J. Physiol. Heart Circ. Physiol., 282, H1035, 10.1152/ajpheart.00808.2001

Kirchhefer, 2001, Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1, J. Biol. Chem., 276, 4142, 10.1074/jbc.M006443200

Kirchhof, 2003, Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor, Am. J. Physiol., 285, H145, 10.1152/ajpheart.01036.2002

Kirchhof, 2007, Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin, J. Mol. Cell Cardiol., 42, 962, 10.1016/j.yjmcc.2007.02.012

Ledent, 1997, Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor, Nature, 388, 674, 10.1038/41771

Lendeckel, 2005, Expression of opioid receptor subtypes and their ligands in fibrillating human atria, Pacing Clin. Electrophysiol., 28, S275, 10.1111/j.1540-8159.2005.00073.x

Lezoualc’h, 2007, Quantitative mRNA analysis of serotonin 5-HT4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation, Biochem. Biophys. Res. Commun., 357, 218, 10.1016/j.bbrc.2007.03.124

Libert, 1989, Selective amplification and cloning of four new members of the G protein-coupled receptor family, Science., 244, 569, 10.1126/science.2541503

Llach, 2011, Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors, Eur. Heart J., 32, 721, 10.1093/eurheartj/ehq464

Llach, 2011, Sarcoplasmic reticulum and L-type Ca2+ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes, J. Physiol., 589, 3247, 10.1113/jphysiol.2010.197715

Marala, 1998, Immunological characterization of adenosine A2A receptors in human and porcine cardiovascular tissues, J. Pharmacol. Exp. Ther., 286, 1051

Molina, 2016, Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes, Basic Res. Cardiol., 111, 5, 10.1007/s00395-015-0525-2

Monahan, 2000, Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts, Am. J. Physiol. Heart Circ. Physiol., 279, H1472, 10.1152/ajpheart.2000.279.4.H1472

Morrison, 2006, Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes, Am. J. Physiol. Heart Circ. Physiol., 291, H1875, 10.1152/ajpheart.00158.2005

2011, Guide for the care and use of laboratory animals: eighth edition

Neumann, 2017, A2A-adenosine receptor overexpression leads to arrhythmias, JACC Clin. Electrophysiol., 10, S22, 10.1016/j.jacep.2017.09.094

Neumann, 2018, Further studies on the cardiac relevance of human A2A receptors, Purinergic Signaling, 14, 81

Olsson, 1990, Cardiovascular purinoceptors, Physiol. Rev., 70, 761, 10.1152/physrev.1990.70.3.761

Palani, 2011, Safety of regadenoson as a pharmacologic stress agent for myocardial perfusion imaging in chronic kidney disease patients not on hemodialysis, J. Nucl. Cardiol., 18, 605, 10.1007/s12350-011-9378-8

Schapira, 2014, Slowing of neurodegeneration in Parkinson’s disease and Huntington’s disease: future therapeutic perspectives, Lancet, 384, 545, 10.1016/S0140-6736(14)61010-2

Shryock, 1993, Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes, Circ. Res., 72, 194, 10.1161/01.RES.72.1.194

Shryock, 1997, Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology, Am. J. Cardiol., 79, 2, 10.1016/S0002-9149(97)00256-7

Stein, 1998, Regulation of adenosine receptor subtypes and dysfunction in human heart failure, Cardiovascular Biology of Purines., 108, 10.1007/978-1-4615-5603-9_7

Szentmiklosi, 2015, The Janus face of adenosine: antiarrhythmic and proarrhythmic actions, Curr. Pharm. Des., 21, 965, 10.2174/1381612820666141029100346

Voigt, 2012, Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation, Circulation, 125, 2059, 10.1161/CIRCULATIONAHA.111.067306

Wang, 2013, Preladenant, a selective adenosine A₂A receptor antagonist, is not associated with QT/QTc prolongation, Eur. J. Clin. Pharmacol., 69, 1761, 10.1007/s00228-013-1541-5

Yamda, 2001, Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation, J. Am. Coll. Cardiol., 37, 1111, 10.1016/S0735-1097(01)01144-5