The Nrf2 Pathway in Liver DiseasesFrontiers in Cell and Developmental Biology - Tập 10
Jiaming Zhou, Qiuxian Zheng, Zhi Chen
Oxidative stress is the leading cause of most liver diseases, such as
drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by
drugs, viruses, and ethanol. The Kelch-like ECH-associated protein
1-NFE2-related factor 2 (Keap1-Nrf2) system is a critical defense mechanism of
cells and organisms in response to oxidative stress. Accelerating studies have
clarified that the Keap1-Nr... hiện toàn bộ
Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and HumansFrontiers in Cell and Developmental Biology - Tập 8
Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A. Chowdhury, Salomon Narodden, Stephen Rothery, Robert Podovei, Jose L. Sanchez‐Alonso, Elisa Ferraro, Pamela Swiatlowska, Siân E. Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, Susanne Sattler
Endomembrane Tension and TraffickingFrontiers in Cell and Developmental Biology - Tập 8
Amra Sarić, Spencer A. Freeman
Eukaryotic cells employ diverse uptake mechanisms depending on their specialized
functions. While such mechanisms vary widely in their defining criteria: scale,
molecular machinery utilized, cargo selection, and cargo destination, to name a
few, they all result in the internalization of extracellular solutes and fluid
into membrane-bound endosomes. Upon scission from the plasma membrane, this
comp... hiện toàn bộ
MicroRNA-505, Suppressed by Oncogenic Long Non-coding RNA LINC01448, Acts as a Novel Suppressor of Glycolysis and Tumor Progression Through Inhibiting HK2 Expression in Pancreatic CancerFrontiers in Cell and Developmental Biology - Tập 8
Zhenglei Xu, Dingguo Zhang, Zhuliang Zhang, Weixiang Luo, Rui-Yue Shi, Jun Yao, De‐Feng Li, Lisheng Wang, Bihong Liao
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play vital
regulatory roles in pancreatic cancer (PC) initiation and progression. We aimed
to explore the biological functions and underlying mechanisms of miR-505-3p
(miR-505) in PC.Methods: We first screened miRNA expression profiles using
microarray in PC tissues and normal tissues, and then studied the function and
underlying me... hiện toàn bộ