Frontiers in Cell and Developmental Biology

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TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties
Frontiers in Cell and Developmental Biology - Tập 8
Ghada Beldi, Georges Uzan, Chloé Lezin, Mahsa Nouri Barkestani, Mohamed Essameldin Abdelgawad, Sina Naserian
Mesenchymal stem cells (MSCs) have drawn lots of attention as gold standard stem cells in fundamental and clinical researches during the last 20 years. Due to their tissue and vascular repair capacities, MSCs have been used to treat a variety of degenerative disorders. Moreover, MSCs are able to modulate immune cells’ functions, particularly T cells while inducing regulatory T cells (iTreg...... hiện toàn bộ
Sending Out an SOS: Mitochondria as a Signaling Hub
Frontiers in Cell and Developmental Biology - Tập 4
Iryna Bohovych, Oleh Khalimonchuk
Roles of Macrophages in the Development and Treatment of Gut Inflammation
Frontiers in Cell and Developmental Biology - Tập 9
Xuebing Han, Sujuan Ding, Hongmei Jiang, Gang Liu
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and...... hiện toàn bộ
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation
Frontiers in Cell and Developmental Biology - Tập 8
Jenny Ostrop, Rosalie T. Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, N. Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim B. Jensen, C.H. Arrowsmith, Menno J. Oudhoff
Intestinal organoids are an excellent model to study epithelial biology. Yet, the selection of analytical tools to accurately quantify heterogeneous organoid cultures remains limited. Here, we developed a semi-automated organoid screening method, which we applied to a library of highly specific chemical probes to identify epigenetic regulators of intestinal epithelial biology. The role of ...... hiện toàn bộ
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins
Frontiers in Cell and Developmental Biology - Tập 9
Renate Jansen, Carlos Santana‐Molina, Marco van den Noort, Damien P. Devos, Ida J. van der Klei
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a comparative genomics approach, we clarify the evolutionary relationships between the 37 known PEX proteins in a representative set of eukaryotes, including all common model organisms, pathogenic unicellular eukaryotes and human. A large number of previously unknown PEX orthologs were identified. We analy...... hiện toàn bộ
Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14
Frontiers in Cell and Developmental Biology - Tập 9
Stefan Gaussmann, Mohanraj Gopalswamy, Maike Eberhardt, Maren Reuter, Peijian Zou, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler
Human PEX5 and PEX14 are essential components of the peroxisomal translocon, which mediates import of cargo enzymes into peroxisomes. PEX5 is a soluble receptor for cargo enzymes comprised of an N-terminal intrinsically disordered domain (NTD) and a C-terminal tetratricopeptide (TPR) domain, which recognizes peroxisomal targeting signal 1 (PTS1) peptide motif in cargo proteins. The PEX5 NT...... hiện toàn bộ
The Peroxisomal Targeting Signal 3 (PTS3) of the Budding Yeast Acyl-CoA Oxidase Is a Signal Patch
Frontiers in Cell and Developmental Biology - Tập 8
Błażej Kempiński, Anna Chełstowska, Jarosław Poznański, Kamil Król, Łukasz Rymer, Zuzanna Frydzińska, Wolfgang Girzalsky, Adrianna Skoneczna, Ralf Erdmann, Marek Skoneczny
Peroxisomal Metabolite and Cofactor Transport in Humans
Frontiers in Cell and Developmental Biology - Tập 8
Serhii Chornyi, Lodewijk IJlst, Carlo W.T. van Roermund, Ronald J. A. Wanders, Hans R. Waterham
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors involved across the peroxisomal membrane. Although much progress has been made in understanding the permeability properties of peroxisomes, there...... hiện toàn bộ
SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway
Frontiers in Cell and Developmental Biology - Tập 8
Aiwen Shen, Lili Fu, Lin Lü, Bo Sun, Dong-Xu Song, Wutao Wang, Yihao Wang, Peiran Yin, Shengqiang Yu
The Effects of Biomaterial Implant Wear Debris on Osteoblasts
Frontiers in Cell and Developmental Biology - Tập 8
Li Zhang, El-Mustapha Haddouti, Kristian Welle, C. Burger, Dieter C. Wirtz, Frank A. Schildberg, Koroush Kabir
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