Frontiers in Cell and Developmental Biology

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The Nrf2 Pathway in Liver Diseases
Frontiers in Cell and Developmental Biology - Tập 10
Jiaming Zhou, Qiuxian Zheng, Zhi Chen
Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (Keap1-Nrf2) system is a critical defense mechanism of cells and organisms in response to oxidative stress. Accelerating studies have clarified that the ...... hiện toàn bộ
Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment
Frontiers in Cell and Developmental Biology - Tập 7
Tianyi Liu, Linli Zhou, Danni Li, Thomas Andl, Yuhang Zhang
The Effects of Biomaterial Implant Wear Debris on Osteoblasts
Frontiers in Cell and Developmental Biology - Tập 8
Li Zhang, El-Mustapha Haddouti, Kristian Welle, C. Burger, Dieter C. Wirtz, Frank A. Schildberg, Koroush Kabir
Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans
Frontiers in Cell and Developmental Biology - Tập 8
Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A. Chowdhury, Salomon Narodden, Stephen Rothery, Robert Podovei, Jose L. Sanchez‐Alonso, Elisa Ferraro, Pamela Swiatlowska, Siân E. Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, Susanne Sattler
Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis
Frontiers in Cell and Developmental Biology - Tập 7
Abeer F. Alharbi, John Parrington
Endomembrane Tension and Trafficking
Frontiers in Cell and Developmental Biology - Tập 8
Amra Sarić, Spencer A. Freeman
Eukaryotic cells employ diverse uptake mechanisms depending on their specialized functions. While such mechanisms vary widely in their defining criteria: scale, molecular machinery utilized, cargo selection, and cargo destination, to name a few, they all result in the internalization of extracellular solutes and fluid into membrane-bound endosomes. Upon scission from the plasma membrane, t...... hiện toàn bộ
Organotypic brain slice cultures as a model to study angiogenesis of brain vessels
Frontiers in Cell and Developmental Biology - Tập 3
Bianca Hutter-Schmid, Kathrin M. Kniewallner, Christian Humpel
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis
Frontiers in Cell and Developmental Biology - Tập 3
Mayumi Kitagawa, Sang Hyun Lee
MicroRNA-505, Suppressed by Oncogenic Long Non-coding RNA LINC01448, Acts as a Novel Suppressor of Glycolysis and Tumor Progression Through Inhibiting HK2 Expression in Pancreatic Cancer
Frontiers in Cell and Developmental Biology - Tập 8
Zhenglei Xu, Dingguo Zhang, Zhuliang Zhang, Weixiang Luo, Rui-Yue Shi, Jun Yao, De‐Feng Li, Lisheng Wang, Bihong Liao
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play vital regulatory roles in pancreatic cancer (PC) initiation and progression. We aimed to explore the biological functions and underlying mechanisms of miR-505-3p (miR-505) in PC.Methods: We first screened miRNA expression profiles using microarray in PC tiss...... hiện toàn bộ
Quantified CIN Score From Cell-free DNA as a Novel Noninvasive Predictor of Survival in Patients With Spinal Metastasis
Frontiers in Cell and Developmental Biology - Tập 9
Chen Su, Minglei Yang, Nanzhe Zhong, Dong Yu, Jian Jiao, Dongjie Jiang, Yasong Xiao, Wei Wei, Tianzhen Wang, Yan Lou, Zhenhua Zhou, Wei Xu, Wan Wan, Zhipeng Wu, Haifeng Wei, Tielong Liu, Jian Zhao, Xinghai Yang, Jianru Xiao
Purpose: Most currently available scores for survival prediction of patients with bone metastasis lack accuracy. In this study, we present a novel quantified CIN (Chromosome Instability) score modeled from cfDNA copy number variation (CNV) for survival prediction.Experimental Design: Plasma samples collected from 67 patients wi...... hiện toàn bộ
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